High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss

British Journal of Cancer

Volumn 74, Issue 6, 1996, Pages 839-845

  Oudard, S ^a   Arvelo, F ^a   Miccoli, L ^a   Apiou, F ^a   Dutrillaux, A M ^a   Poisson, M ^b   Dutrillaux, B ^a   Poupon, M F ^a  

^a INSTITUT CURIE   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

ATP; Chromosome 10; Glioblastoma; Glycolysis; Hexokinase; HK I mRNA

Indexed keywords

HEXOKINASE; LACTATE DEHYDROGENASE; LACTIC ACID; MESSENGER RNA; PYRUVIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; CHROMOSOME 10; CHROMOSOME LOSS; CLINICAL ARTICLE; GLIOBLASTOMA; GLYCOLYSIS; HUMAN; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

EID: 0029736904     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.446     Document Type: Article

References (39)

1. ARORA KK AND PEDERSEN PL. (1988). Functional significance of mitochondrial bound hexokinase in tumor cell metabolism: evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. J. Biol. Chem., 263, 17422-17428.
2. BARDOT V, LUCCIONI C, LEFRANCOIS D, MULERIS M AND DUTRILLAUX B. (1991). Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns. Int. J. Cancer, 47, 670-674.
3. BELTRANDELRIO H AND WILSON JE. (1991). Hexokinase of rat brain mitochondria: relative importance of adenylate kinase and oxidative phosphorylation as source of substrate ATP, and interaction with intramitochondrial compartments of ATP and ADP. Arch. Biochem. Biophys., 286, 183-194.
4. BIGNER S AND MARK J. (1984). Chromosomes and chromosomal progression of human gliomas in vivo, in vitro and in athymic nude mice. Prog. Exp. Tumor Res., 27, 67-82.
5. BIGNER SH, MARK J, BURGER PC, MAHALEY MS, BULLARD DE, MUHLBAIER LH AND BIGNER DD. (1988). Specific chromosomal abnormalities in malignant human gliomas. Cancer Res., 48, 405-411.
6. BIGNER SH, MARK J AND BIGNER DD. (1990). Cytogenetics of human brain tumors. Cancer Genet. Cytogenet., 47, 141-154.
7. BONDY M, WIENCKE J, WRENSCH M AND KYRISTSIS AP. (1994). Genetics of primary brain tumors: a review. J. Neurooncol., 18, 69-81.
8. BRAVARD A, HOFFSCHIR F, SABATIER L, RICOUL M, PINTON A, CASSINGENA R, ESTRADE S, LUCCIONI C AND DUTRILLAUX B. (1992). Early superoxide dismutase alterations during SV40-transformation of human fibroblasts. Int. J. Cancer, 52, 797-801.
9. BURGER PC. (1986). Malignant astrocytic neoplasms: classification, pathologic anatomy, and response to treatment. Semin. Oncol., 13, 16-26.
10. CHIGWIN JM, PRZYBYLA AE, MACDONALD RJ AND RUTTER W. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
11. FANCIULLI M, PAGGI MG, BRUNO T, CARLO CD, BONETTO F, GENTILE FP AND FLORIDI A. (1994). Glycolysis and growth rate in normal and in hexokinase-transfected NIH-3T3 cells. Oncol. Res., 6, 405-409.
12. FLORIDI A, PAGGI MG AND FANCIULLI M. (1989). Modulation of glycolysis in neuroepithelial tumors. J. Neurosurg, Sci., 33, 55-64.
13. FORT P, MARTY L, PIECHACZYK M, SABROUTY E, DANI C, JEANTEUR P AND BLANCHARD J. (1985). Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res., 13, 1431-1442.
14. FUJIMOTO M, FULTS DW, THOMAS GA, NAKAMURA Y, HEILBRUN MP, WHITH R, STORY JL, NAYLOR SL, KAGAN-HALLET KS AND SHERIDAN PJ. (1989). Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme. Genomics, 4, 210-214
15. GRAHAM JF, CUMMINS CJ, SMITH BH AND KORNBLITH PL. (1985). Regulation of hexokinase in cultured gliomas. Neurosurgery, 17, 537-542.
16. HOFFSCHIR F, VUILLAUME M, SABATIER L, RICOUL M, DAYAGROSJEAN L, ESTRADE S, CASSINGENA R, CALVAYRAC R, SARASIN A AND DUTRILLAUX B. (1993). Decrease in catalase activity and loss of the lip chromosome arm in the course of SV40 transformation of human fibroblasts. Carcinogenesis, 14, 1569-1572.
17. JAMES CD, CARLBOM E, DUMANSKI JP, HANSEN M, NORDENSKJOLD M, COLLINS VP AND CAVENEE WK. (1988). Clonal genomic. alterations in glioma malignancy stages. Cancer Res., 48, 5546-5551.
18. LASSERRE C, SABATIER L, BEAUMATIN J, LUCCIONI C, LEFRANCOIS D, MULLERIS M AND DUTRILLAUX B. (1994). Gene-dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas. Int. J Cancer, 56, 1-6.
19. LATERVEER FD, HEIJDEN RVD, TOONEN M AND NICOLAY K. (1994). The kinetic consequences of binding of hexokinase-I to the mitochondrial outer membrane. Biochim. Biophys. Acta, 1188, 251-259.
20. LOWRY OH, BERGER SJ, CARTER JG, CHI MMY, MANCHESTER JK, KNOR J AND PUSATERI ME. (1983). Diversity of metabolic patterns in human brain tumors: enzymes of energy metabolism and related metabolites and cofactors. J. Neurochem., 41, 994-1010.
21. LUNDIN A, HASENSON M, PERSSON J AND POUSETTE A. (1986). Estimation of biomass in growing cell lines by adenosine triphosphate assay. Methods Enzymol., 113B, 27-42
22. MACBETH RAL AND BEKESI JG. (1962). Oxygen consumption and anaerobic glycolysis of human malignant and normal tissue. Cancer Res., 22, 244-248.
23. MCCABE ERB. (1994). Microcompartmentation of energy metabolism at the outer mitochondrial membrane: role in diabetes mellitus and other diseases. J. Bioenerg. Biomembr., 26, 307-315.
24. MAGDELÉNAT H, GERBAULT-SEUREAU M AND DUTRILLAUX B. (1994). Relationship between loss of estrogen and progesterone receptor expression and of 6q and 11q chromosome arms in breast cancer. Int. J. Cancer, 57, 63-66.
25. MANIATIS T, FRITCH F, AND SAMBROOK J. (1982). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York.
26. MICCOLI L, OUDARD S, SUREAU F, POIRSON F, DUTRILLAUX B AND POUPON MF. (1996). Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line. Biochem. J., 313, 957-962.
27. NISHI S, SEINO S AND BEL GI. (1988). Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous. Biochem. Biophys. Res. Comm., 157, 937-943.
28. OUDARD S, POIRSON F, MICCOLI L, BOURGEOIS Y, VASSAULT A, POISSON M, MAGDELÉNAT H, DUTRILLAUX B AND POUPON MF. (1995). Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Int. J. Cancer, 62, 216-222.
29. PARRY DM AND PEDERSEN PL. (1990). Glucose catabolism in brain. J. Biol. Chem., 265, 1059-1066.
30. PEDERSEN PL. (1978). Tumor mitochondria and the bioenergetics of cancer cells. Prog. Exp. Tumor Res., 22, 190-274.
31. SCHWARTZ D. (1994). Méthodes Statistiques à l'Usage des Médecins et des Biologistes, 4th edn, Medecine-Sciences Flammarion: Paris.
32. SHOWS TB, EDDY RL, BYERS MG, HALEY LL, HENRY WM, NISHI S AND BELL GI. (1989). Localization of the human hexokinase I gene (HK1) to chromosome 10q22. Cytogenet. Cell. Genet., 51, 1079.
33. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in conscious and anesthetized albino rats. J. Neurochem., 28, 897-916.
34. SPRENGERS ED, KOENDERMAN AHL AND STAAL GEJ. (1983). Mitochondrial and cytosolic hexokinase from rat brain: one and the same enzyme? Biochim. Biophys. Acta, 755, 112-118.
35. STECK PA, LIGON AH, CHEONG P, YUNG WKA AND PERSHOUSE MA. (1995). Two tumor-suppressive loci on chromosome 10 involved in human glioblastomas. Genes Chrom. Cancer, 12, 255-261.
36. VASSAULT A, BONNEFONT JP, SPECOLA N AND SAUDUBRAY JM. (1991). Lactate, pyruvate and ketone bodies. In Techniques in Diagnostic Human Biochemical Genetics, a Laboratory Manual. Hommes SA (ed) pp. 285-308. Wiley-Liss: New York.
37. WARBURG O. (1956). On the origin of cancer cells. Science, 123, 309-314.
38. WATANABE K, NAGAI M AND WAKAI S. (1990). Loss of constitutional heterozygosity in chromosome 10 in human glioblastoma. Acta Neuropathol., 80, 251-254.
39. WILSON JE. (1995). Hexokinases. Rev. Physiol. Biochem. Pharmacol., 126, 65-198.