p53 and p21 are major cellular determinants for DNA topoisomerase I-mediated radiation sensitization in mammalian cells

Annals of the New York Academy of Sciences

Volumn 922, Issue , 2000, Pages 298-300

  Chen, Allan Y ^a   Scruggs, Paul B ^a   Geng, Ling ^a   Rothenberg, Mace L ^a   Hallahan, Dennis E ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; ANTINEOPLASTIC AGENT; APHIDICOLIN; CAMPTOTHECIN DERIVATIVE; CORDYCEPIN; DNA TOPOISOMERASE; ETICYCLIDINE; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; CANCER; CATALYSIS; CELL CYCLE PHASE; CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA METABOLISM; DRUG TARGETING; HUMAN; HUMAN CELL; MAMMAL CELL; MULTIMODALITY CANCER THERAPY; NONHUMAN; RADIOSENSITIZATION;

ANIMALIA; MAMMALIA;

EID: 0034513568     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb07047.x     Document Type: Conference Paper

References (10)

1. Principles of cancer management: Radiation therapy
2. Chemotherapy and radiation
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4. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
5. Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864)
6. Down-regulation of topoisomerase I in mammalian cells following ionizing radiation
7. Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives
8. DNA topoisomerase I-targeting drugs as radiation sensitizers
9. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
10. Requirement for p53 and p21 to sustain G2 arrest after DNA damage