The role of metabolites in bioequivalency assessment. III. Highly variable drugs with linear kinetics and first-pass effect

Pharmaceutical Research

Volumn 17, Issue 11, 2000, Pages 1432-1436

  Jackson, A J ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bioequivalence; Intrinsic clearance; Metabolites

Indexed keywords

CLOMIPRAMINE; ISOSORBIDE DINITRATE; TERFENADINE;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG METABOLISM; FIRST PASS EFFECT; HUMAN; LIVER BLOOD FLOW; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CLINICAL TRIALS; CLOMIPRAMINE; COMPUTER SIMULATION; DELAYED-ACTION PREPARATIONS; HISTAMINE H1 ANTAGONISTS; HUMANS; ISOSORBIDE DINITRATE; KINETICS; LIVER; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MONTE CARLO METHOD; TERFENADINE; THERAPEUTIC EQUIVALENCY; VASODILATOR AGENTS;

EID: 0034495152     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007581016352     Document Type: Article

References (14)

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