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Volumn 15, Issue 1, 1998, Pages 98-104
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Evaluation of bioequivalence of highly variable drugs using clinical trial simulations. II: Comparison of single and multiple-dose trials using AUC and Cmax
a
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Author keywords
Bioequivalence; Extent of absorption; Highly variable drugs; Monte Carlo simulations; Multiple dose bioequivalence trial; Rate of absorption; Single dose
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Indexed keywords
ANTIBIOTIC AGENT;
ANTIHISTAMINIC AGENT;
ANTIINFLAMMATORY AGENT;
CALCIUM CHANNEL BLOCKING AGENT;
AREA UNDER THE CURVE;
ARTICLE;
BIOEQUIVALENCE;
COMPARTMENT MODEL;
COMPUTER SIMULATION;
DRUG ABSORPTION;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG DISTRIBUTION;
DRUG DOSE;
DRUG FORMULATION;
HUMAN;
METHODOLOGY;
PRIORITY JOURNAL;
SUSTAINED RELEASE FORMULATION;
SYSTEM ANALYSIS;
VARIANCE;
AREA UNDER CURVE;
COMPUTER SIMULATION;
DRUG COMBINATIONS;
METABOLIC CLEARANCE RATE;
MODELS, CHEMICAL;
MONTE CARLO METHOD;
PHARMACOKINETICS;
THERAPEUTIC EQUIVALENCY;
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EID: 0031913404
PISSN: 07248741
EISSN: None
Source Type: Journal
DOI: 10.1023/A:1011961006297 Document Type: Article |
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Times cited : (36)
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References (12)
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