Interaction of alveolar macrophages with inhaled mineral particulates

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 13, Issue 4, 2000, Pages 369-380

  Dorger M ^a   Krombach, F ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cytokines; Eicosanoids; Macrophages; Nitric oxide; Phagocytosis; Reactive oxygen species; Signal transduction; Species differences

Indexed keywords

ASBESTOS FIBER; CARBONYL IRON; CYTOKINE; GROWTH FACTOR; ICOSANOID; MINERAL; NITRIC OXIDE; NITROGEN; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; TITANIUM DIOXIDE;

CHRONIC INFLAMMATION; CONFERENCE PAPER; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG DISEASE; MACROPHAGE ACTIVATION; OPSONIZATION; PARTICULATE MATTER; PHAGOCYTOSIS; SIGNAL TRANSDUCTION; SOOT; TRANSCRIPTION INITIATION;

EID: 0034495106     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2000.13.369     Document Type: Conference Paper

References (141)

1. Use of mechanistic data in assessing human risks from exposure to particles
2. Non-animal tests for evaluating the toxicity of solid xenobiotics
3. The effect of fiber length on the dissolution by macrophages of rockwool and glasswool fibers
4. In vitro cytotoxicity of asbestos and man-made vitreous fibers: Roles of fiber length, diameter and composition
5. Man-made mineral fibers (MMMF): Human exposures and health risk assessment
6. Cellular and molecular basis of the asbestos-related diseases
7. Mechanisms in the pathogenesis of asbestosis and silicosis
8. The alveolar macrophage
9. Alterations in macrophage functions by environmental chemicals
10. Mechanisms of mineral fibre carcinogenesis
11. New perspectives on basic mechanisms in lung disease. 5. Respirable industrial fibres: Mechanisms of pathogenicity
12. Particulate air pollution and acute health effects
13. Air pollution and daily mortality: A review and meta analysis
14. Acute effects of PM10 pollution on pulmonary function of smokers with mild to moderate chronic obstructive pulmonary disease
15. Cytokines and cytokine network in silicosis and coal workers pneumoconiosis
16. Correlation between particle size, in vivo particle persistence, and lung injury
17. Ultrafine particles as a potential environmental health hazard. Studies with model particles
18. In vivo and in vitro proinflammatory effects of particulate air pollution (PM10)
19. Respiratory effects are associated with the number of ultrafine particles
20. Tumors in the rat following intraperitoneal injections of fibrous dust
21. Mechanisms of mesothelioma induction with asbestos and fibrous glass
22. Mineral fibre carcinogenesis: Experimental data relating to the importance of fibre type, size, deposition, dissolution and migration
23. Toxicokinetics of solid particles in chronic rat studies using diesel soot, carbon black, toner, titanium dioxide and quartz
24. Pathologic effects of inhaled particles in rat lungs: Association between inflammatory and neoplastic processes
25. The role of free radicals in asbestos-induced diseases
26. Iron in asbestos chemistry and carcinogenicity
27. Role of iron in the re activity of mineral fibers
28. Alveolar macrophage uptake of the environmental particulate titanium dioxide: Role of surfactant components
29. Differential release of superoxide anions by macrophages treated with long and short fibre amosite asbestos is a consequence of differential affirnity for opsonin
30. Effect of coating with lung lining fluid on the ability of fibres to produce a respiratory burst in rat alveolar macrophages
31. In vitro bioactivity of asbestos for the human alveolar macrophage and its modification by IgG
32. Modification of asbestos bioactivity for the alveolar macrophage by selective protein adsorption
33. Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung
34. Pulmonary macrophages
35. Macrophages and polymorphonuclear neutrophils in lung defense and injury
36. Pulmonary macrophages are attracted to inhaled particles through complement activation
37. Time course of chemotactic factor generation and the corresponding macrophage response to asbestos inhalation
38. Inhaled asbestos activates a complement-dependent chemoattractant for macrophages
39. Role of the alveolar macrophage in lung injury: Studies with ultrafine particles
40. Cytotoxicity and cell stimulating activity of ultrafine titanium dioxide
41. Phagocytosis
42. Lung macrophage uptake of unopsonized environmental particulates. Role of scavenger-type receptors
43. Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos
44. Effects of fibres on cell proliferation, cell activation and gene expression
45. Alveolar macrophage interaction with air pollution particulates
46. Scavenger receptors in innate immunity
47. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles
48. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
49. Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysis
50. Surface morphology and correlated phagocytic capacity of pulmonary macrophages lavaged from the lungs of rats
51. Decreased CD11b expression, phagocytosis, and oxidative burst in urban particulate pollution-exposed human monocytes and alveolar macrophages
52. Scanning electron microscopic study on the changes in the cell surface morphology of rat alveolar macrophages after their exposure to man-made vitreous fibers
53. Retention and intracellular dis-tribution of instilled iron oxide particles in human alveolar macrophages
54. Alveolar macrophages in a particle "overload" condition
55. Clearance of particles deposited in the lungs
56. Interspecies comparison of lung clearance of "insoluble" particles
57. An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles: I. Objectives and summary of results
58. Possible mechanisms to explain dust overloading of the lungs
59. Current perspectives on particulate induced pulmonary tumours
60. The role of clearance and dissolution in determining the durability or biopersistence of mineral fibers
61. Volumetric loading of alveolar macrophages (AM): A possible basis for diminished AM-mediated particle clearance
62. Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation
63. Intracellular particle dissolution in alveolar macrophages
64. In vivo evaluation of chemical biopersistence of nonfibrous inorganic particles
65. Dissolution of short and long rockwool and glasswool fibers by macrophages in flowthrough cell culture
66. Asbestosis: Clinical spectrum and pathogenic mechanisms
67. Evidence that exposure of particulate air pollutants to human and rat alveolar macrophages leads to differential oxidative response
68. Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models
69. Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat
70. Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils
71. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro
72. Oxygen-derived species: Their relation to human disease and environmental stress
73. Regulation of antioxidant enzymes in lung after oxidant injury
74. Evidence that exposure of particulate air pollutants to human and rat alveolar macrophages leads to differential oxidative response
75. Stimulation of human and rat alveolar macrophages by urban air particulates: Effects on oxidant radical generation and cytokine production
76. Prevention of asbestos-induced cell death in rat lung fibroblasts and alveolar macrophages by scavengers of active oxygen species
77. -) from alveolar macrophages exposed to asbestiform and nonfibrous particles
78. Superoxide anion release by alveolar macrophages exposed to respirable industrial fibres: Modifying effect of fibre opsonisation
79. Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages
80. Enhancement of the macrophage oxidative burst by immunoglobulin coating of respirable fibers: Fiber-specific differences between asbestos and man-made fibers
81. Asbestos fibers and interferon-gamma up-regulate nitric oxide production in rat alveolar macrophages
82. Nitric oxide (NO) synthase activity in the lung and NO synthesis in alveolar macrophages of rats increased on exposure to asbestos
83. Enhancement of nitric oxide production by pulmonary cells following silica exposure
84. Comparison of inducible nitric oxide synthase gene expression and lung inflammation following intratracheal instillation of silica, coal, carbonyl iron, or titanium dioxide in rats
85. Oxidative stress: Oxidants and antioxidants
86. The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates
87. Differential effects of mineral dusts on the in vitro activation of alveolar macrophage eicosanoid and cytokine release
88. Cytokines of the lung [see comments]
89. Cytokines and particle-induced inflammatory cell recruitment
90. Alveolar macrophage cytokine and growth factor production in a rat model of crocidolite-induced pulmonary inflammation and fibrosis
91. Distinctive profile of alveolar macrophage-derived cytokine release induced by fibrogenic and nonfibrogenic mineral dusts
92. Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages
93. Systemic macrophage stimulation in rats with silicosis: Enhanced release of tumor necrosis factor-alpha from alveolar and peritoneal macrophages
94. Human alveolar macrophage cytokine release in response to in vitro and in vivo asbestos exposure
95. Production of tumor necrosis factor-alpha and interleukin-6 by human alveolar macrophages exposed in vitro to coal mine dust
96. Cytokines and cytokine network in silicosis and coal workers pneumoconiosis
97. Effects of diesel exhaust particles on the release of interleukin-1 and tumor necrosis factor-alpha from rat alveolar macrophages
98. Effect of long and short fibre amosite asbestos on in vitro TNF production by rat alveolar macrophages: The modifying effect of lipopolysaccharide
99. Asbestos-stimulated tumour necrosis factor release from alveolar macrophages depends on fibre length and opsonization
100. Macrophage inflammatory proteins 1 and 2: Expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung after mineral dust exposure
101. Elevated interleukin-8 in the alveolitis of individuals with asbestos exposure
102. Additional NO2 exposure induces a decrease in cytokine specific mRNA expression and cytokine release of particle and fibre exposed human alveolar macrophages
103. Pulmonary reaction to long and short asbestos fibers is independent of fibrobalst growth factor production by alveolar macrophages
104. Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages
105. Secretion of a platelet-derived growth factor homologue by rat alveolar macrophages exposed to particulates in vitro
106. Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis
107. Pulmonary inflammation and fibrosis in a murine model of asbestosis and silicosis. Possible role of tumor necrosis factor
108. Secretion of fibronectin by mineral dust-derived alveolar macrophages and activated peritoneal macrophages
109. Characterization of the lower respiratory tract inflammation of nonsmoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts
110. Modulation of eicosanoid production by human alveolar macrophages exposed to silica in vitro
111. Refractory ceramic fibers activate alveolar macrophage eicosanoid and cytokine release
112. Production of arachidonic acid metabolites by macrophages exposed in vitro to asbestos, carbonyl iron particles, or calcium ionophore
113. Asbestos fibers and silica particles stimulate rat alveolar macrophages to release tumor necrosis factor. Autoregulatory role of leukotriene B4
114. Inhibition of alveolar macrophage cytotoxicity by asbestos: Possible role of prostaglandins
115. Enhanced release of prostaglandin E2 from macrophages of rats with silicosis
116. Reduced release of leukotrienes B4 and C4 from alveolar macrophages of rats with silicosis
117. Mechanisms associated with human alveolar macrophage stimulation by particulates
118. Silica increases cytosolic free calcium ion concentration of alveolar macrophages in vitro
119. Altered calcium homeostasis and cell injury in silica-exposed alveolar macrophages
120. Mechanisms of particle-induced activation of alveolar macrophages
121. Biological effects of manmade mineral fibers (I) - Reactive oxygen species production and calcium homeostasis in alveolar macrophages
122. Role of extracellular calcium in chrysotile asbestos stimulation of alveolar macrophages
123. Agonist-stimulated alveolar macrophages: Apoptosis and phospholipid signaling
124. Silica-induced oxygen radical generation in alveolar macrophages
125. Involvement of protein kinase C, phospholipase C, and protein tyrosine kinase pathways in oxygen radical generation by asbestos-stimulated alveolar macrophage
126. Possible mechanism of chrysotile asbestos-stimulated superoxide anion production in guinea pig alveolar macrophages
127. In vitro study of human alveolar macrophages inflammatory mediator transcriptions and releases induced by soot FP, 101. Printex 90, titandioxide and Chrysotile B
128. Antioxidant and redox regulation of gene transcription
129. Free radical activity of industrial fibers: Role of iron in oxidative stress and activation of transcription factors
130. Cell size of alveolar macrophages: An interspecies comparison
131. Species differences in NO formation by rat and hamster alveolar macrophages in vitro
132. Interspecies comparison of rat and hamster alveolar macrophage antioxidative and oxidative capacity
133. Expression of inducible nitric oxide synthase and formation of nitric oxide by alveolar macrophages: An interspecies comparison
134. Influences of gender, species, and strain differences in pulmonary toxicological assessments of inhaled particles and/or fibers
135. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions
136. Species variation in lung antioxidant enzyme activities
137. Role of alveolar macrophage chemotaxis and phagocytosis in pulmonary clearance responses to inhaled particles: Comparisons among rodent species
138. Interspecies comparisons of lung responses to inhaled particles and gases
139. Comparative physiology of rodent pulmonary macrophages: In vitro functional responses
140. Characteristics of a murine gammaherpesvirus infection immunocompromised mice
141. Functional characterization of recombinant rat macrophage inflammatory protein-1α and mRNA expression in pulmonary inflammation