Intranasal hydroxocobalamin administration: An attractive alternative for intramuscular cobalamin injections in geriatric patients

Drug Development Research

Volumn 51, Issue 3, 2000, Pages 197-199

  Lonterman, S ^a   Van Asselt, D Z B ^a   Rikkert, M G M Olde ^a   Russel, F G M ^b   Hoefnagels, W H L ^a   Merkus, F W H M ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c Center for Bio Pharmaceutical Sciences   (Netherlands)

Author keywords

Aged; Cobalamin; Deficiency; Hydroxocobalamin; Intranasal

Indexed keywords

COBALAMIN; HYDROXOCOBALAMIN;

AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG EFFICACY; DRUG FORMULATION; DRUG INDUCED DISEASE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GERIATRIC DISORDER; HUMAN; MALE; STEADY STATE; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY;

EID: 0034491530     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2299(200011)51:3<197::aid-ddr9>3.0.co;2-%23     Document Type: Article

References (7)

1. Bruins Slot W, Merkus FWHM, Van Deventer SJH, Tytgat GNJ. 1997. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology 113:430-433.
2. Carmel R. 1990. Subtle and atypical cobalamin deficiency states. Am J Hematol 34:108-114.
3. Healton EB, Savage DG, Brust JCM, Garret TJ, Lindenbaum J. 1991. Neurologic aspects of cobalamin deficiency. Medicine 70:229-245.
4. Lindenbaum J, Rosenberg IH, Wilson PWF, Stabler SP, Allen RH. 1994. Prevalence of cobalamin deficiency in the Framingliam elderly population. Am J Clin Nutr 60:2-11.
5. Metz J, Bell AH, Flicker L, Bottiglieri T, Ibrahim J, Seal E, Schultz D, Savoia H, McGrath KM. 1996. The significance of subnormal serum vitamin B12 concentration in older people: a case control study. J Am Geriatr Soc 44:1355-1361.
6. Van Asselt DBZ, Merkus FWHM, Russel FGM, Hoefnagels WHL. 1998. Nasal absorption of hydroxocobalamin in healthy elderly adults. Br J Clin Pharmacol 45:83-86.
7. Van Asselt DZ, Blom HJ, Zuiderent R, Wevers RA, Jakobs C, Van Den Broek WJ, et al. 2000. Clinical significance of low cobalamin levels in older hospital patients. Neth J Med (in press).