Tetramethylpiperidine-substitution increases the antitumor activity of the riminophenazines for an acquired multidrug-resistant cell line

Anti-Cancer Drug Design

Volumn 15, Issue 4, 2000, Pages 303-306

  Van Rensburg, C E J ^a   Joone G K ^a   O'Sullivan, J F ^a  

^a Department of Immunology ^*  (South Africa)

Author keywords

Author; Here; Keywords; Please; Thank; You

Indexed keywords

B 4112; CLOFAZIMINE; GLYCOPROTEIN P; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, SMALL CELL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; P-GLYCOPROTEIN; PHENAZINES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0034488369     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. A new series of phenazines (rimino-compounds) with high antituberculosis activity
2. How cancer cells evade chemotherapy
3. Chemosensitizing interactions of clofazimine and B669 with human K562 erythroleukaemia cells with varying levels of expression of P-glycoprotein
4. Antimycobacterial activities of riminophenazines
5. Ventricular arrhythmia and torsade de pointe: Dose limiting toxicities of the MDR-modulator S9788 in a phase I trial
6. Clofazimine analogues active against a clofazimineresistant organism
7. Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro
8. Activity of phenazine analogues against Mycobacterium leprae infections in mice
9. Tetramethylpiperidine-substituted phenazines inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines
10. Evaluation of the antineoplastic activities of the riminophenazine agents clofazimine and B669 in tumorbearing rats and mice
11. The riminophenazine agents clofazimine and B669 reverse acquired multidrug resistance in a human lung cancer cell line
12. +-adenosine triphosphatase activity in cancer cell lines in vitro
13. The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines
14. Riminophenazine compounds: Pharmacology and antineoplastic potential
15. Novel tetramethylplpendmesubstituted phenazines are potent inhibitors of P-glycoprotein activity in a multidrug resistant cancer cell line
16. B4112, a novel tetramethyl-piperidine-substituted phenazine that inhibits the proliferation of multidrug-resistant cancer cell lines
17. Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates
18. Phase I trial of etoposide with cyclosporin as modulator of multidrug resistance