B4112, a novel tetramethylpiperidine-substituted phenazine that inhibits the proliferation of multidrug-resistant cancer cell lines

Annals of the New York Academy of Sciences

Volumn 886, Issue , 1999, Pages 280-282

  Van Rensburg, C E J ^a,b   Joone G ^a   Van Niekerk, E ^a   Anderson, R ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b NONE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; B 4112; CLOFAZIMINE; PHENAZINE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE;

CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN K 562; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE;

EID: 0033452554     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb09436.x     Document Type: Conference Paper

References (6)

1. 1. Van Rensburg, C.E.J., R. Anderson & J.F. O'Sullivan. 1997. Riminophenazine compounds: Pharmacology and anti-neoplastic potential. Crit. Rev. Oncol. Hematol. 25: 55-67.
2. 2-mediated oxidative and non-oxidative mechanisms. Cancer Res. 53:318-323.
3. 3. Van Rensburg, C.E.J., R. Anderson, M.S. Myer et al. 1994. The riminophenazine agents clofazimine and B669 reverse acquired multidrug resistance in a human lung cancer cell line. Cancer Lett. 85: 59-63.
4. 4. Van Rensburg, C.E.J., C. Durandt, P.J. Garlinski et al. 1993. Evaluation of the antineoplastic activities of the riminophenazine agents clofazimine and B669 in tumor-bearing rats and mice. Int. J. Oncol. 3: 1011-1013.
5. 5. Sri-Pathmanathan, R.M., J.A. Plumb & K.C.H. Fearon. 1994. Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo. Int. J. Cancer 56: 900-905.
6. 6. Ruff, P., M.R. Chasen, J.E.H. Long et al. 1998. A phase II study of oral clofazimine in unresectable and metastatic hepatocellular carcinoma. Ann. Oncol. 9: 217-219.