Tempicol-3, a novel piperidine-N-oxide stable radical and antioxidant, with low toxicity acts as apoptosis inducer and cell proliferation modifier of Yoshida Sarcoma cells in vivo

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4611-4618

  Koceva Chyla, A ^a   Kochman, A ^a   Glebska, J ^a   Gwozdzinski K ^a   Jozwiak Z ^a   Metodiewa D ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

Apoptosis; Cytotoxicity; Hydroxyl radical; Nitroxide N oxide; Reducibility

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; HYDROXYL RADICAL; NITROXIDE DERIVATIVE; PIPERIDINE DERIVATIVE; SCAVENGER; TEMPACE; TEMPICOL 3; TEMPO; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFICACY; EMBRYO; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMA CELL; STRUCTURE ACTIVITY RELATION; YOSHIDA SARCOMA;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; ASCITES; CELL DIVISION; CYCLIC N-OXIDES; DRUG SCREENING ASSAYS, ANTITUMOR; MICE; PIPERIDINES; RATS; RATS, INBRED BUF; SARCOMA, YOSHIDA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034483321     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Tempace and Troxyl - Novel synthesized 2,2,6,6-tetramethylpiperidine derivatives as antioxidant and radioprotectors
2. Rutoxyl [rutin/4-acetamide 1-hydroxy-2,2,6,6-tetramethylpiperidinium] is a new member of the class of semi-natural products of high pharmacological potency
3. Tempicol-2(4-hydroxy-4(2-picolyl)-2,2,6,6-tetramethylpiperidine-1-oxyl), a stable free radical, is a novel member of nitroxide class of antioxidants and anticancer agents
4. Induction of programmed cell death (apoptosis) in Sarcoma Yoshida cells by novel nitroxide derivatives
5. TTT, a novel free radical spin trap, induced apoptosis in Sarcoma Yoshida cells in vivo: Comparative investigation of its cytotoxicity in vitro
6. Metexyl (4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxyl) as an oxygen radicals scavenger and apoptosis inducer in vivo
7. Antiproliferative and cytotoxic effects of N,N-diethylaminoethyl ethers of flavanone oximes: A comparison with antracycline(s), anthraquinone and nitroxides action
8. Evidence for peroxidatic oxidation of substituted piperidine nitroxides, acting as apoptosis inducers in Yoshida Sarcoma cells in vivo
9. Nitroxides as antioxidants
10. - or as SOD mimics?
11. Absolute rate constants for the reactions of some carbon-centered radicals with 2,2,6,6-tetramethylpiperidine-N-oxyl
12. Inhibition of lipid peroxidation by spin labels. Relationships between structure and function
13. Protective effect of the nitroxide Tempol against the cardiotoxicity of Adriamycin
14. Studies on structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage
15. Kinetics of superoxide-induced exchange among nitroxide antioxidants and their oxidized and reduced forms
16. Both hydroxylamine and nitroxide protect cardiomyocytes from oxidative stress
17. Nitroxide metabolism in the human keratinocyte cell line HaCaT
18. Hydroxylamine as a new motif for the molecular recognition of phosphodiesters: Implications for aminoglycoside - RNA interactions
19. Stable nitroxide radicals protect lipid acyl chains from radiation damage
20. Paradoxical induction of type 1 programmed cell death in U 937 cells by an antioxidant or the free radical spin trap NTBN
21. NTBN, a free radical spin trap induces programmed cell death in human pancreatic cancer (PANC-1) cells
22. The paradoxical apoptotic effects of novel nitroxide antioxidants on Yoshida Sarcoma cells in vivo: A commentary. Anticancer Res (submitted)
23. Potential use of nitroxides in radiation oncology
24. Studies on an ascites (reticuloendothelial cell) sarcoma of tke rat
25. Piperidine nitroxide radicals with heterocyclic ring substituents
26. Deoxyribose assay for detecting hydroxyl radicals
27. Factors that influence the deoxyribose oxidation assay for Fenton reaction products
28. Oxygen - Dependent reduction of nitroxides by ascorbic acid and glutathione. An ESR study
29. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
30. Neurophysiological consequences of nitroxide antioxidants
31. ESR studies on nitroxide radical 2,2,6,6-tetramethyl-4-piperidin-1-oxyl (Tempo) redox reactions in human skin
32. Nitroxide Spin Labels. Reaction in Biology and Medicine
33. Use of nitroxides to measure redox metabolism in cells and tissues
34. Chemical and electrochemical reduction rates of cyclic nitroxides (nitroxyls)
35. Superoxide ion as activite intermediate in the autoxidation of ascorbate by molecular oxygen
36. Some properties of the ascorbate free radical
37. Inhibition of oxygen - Dependent radiation - Induced damage by the nitroxide superoxide dismutase mimic
38. Cytotoxicity of spin trapping compounds