Immunocytochemical detection of MMP-3 and -10 expression in hepatocellular carcinomas

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4585-4590

  Bodey, B ^a   Bodey B , Jr ^a   Siegel, S E ^a   Kaiser, H E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Dedifferentiation; Extracellular matrix; Hepatocellular carcinoma (HCC); Invasion; Matrix metalloproteinases (MMPs); Metastasis; Tumor tissue progression

Indexed keywords

ALKALINE PHOSPHATASE; CYTOKINE; GELATINASE A; GELATINASE B; GROWTH FACTOR; PROTEIN ANTIBODY; STROMELYSIN; STROMELYSIN 2;

ARTICLE; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL CARCINOMA; METASTASIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; TUMOR CELL;

CARCINOMA, HEPATOCELLULAR; COLLAGENASES; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 10; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; NEOPLASM PROTEINS;

EID: 0034483306     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Cancer statistics, 1996
2. Etiology, pathology, and treatment of hepatocellular carcinoma in North America
3. Hepatocellular carcinoma. A worldwide problem and the major risk factors
4. NIH conference. Hepatocellular carcinoma
5. Epidemiology of hepatocellular carcinoma
6. Relation between aflatoxin, hepatitis-B virus, and hepatocellular carcinoma
7. Cellular and molecular mechanisms of hepatocarcinogenesis
8. Tumors of the liver
9. Primary carcinoma of the liver
10. Prevalence of hepatocellular carcinoma and relation to cirrhosis: Comparison of two different cities of the world - Trieste, Italy, and Chiba, Japan
11. Purification and properties of a gelatin-specific neutral protease from human skin
12. Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin
13. Cleavage specificity of human skin type IV collagenase (gelatinase). Identification of cleavage sites in type I gelatin, with confirmation using synthetic peptides
14. Cleavage of collagen type X by human synovial collagenase and neutrophil elastase
15. Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase
16. Human 92- and 72-kilodalton type IV collagenases are elastases
17. Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages
18. A 92 kDa gelatinase (MMP-9) cleavage site in native type V collagen
19. Relation between substrate specificity and domain structure of 92-kDa type IV collagenase
20. Characteristics of 92 kDa type IV collagenase/gelatinase produced by granulocytic leukemia cells: Structure, expression of cDNA in E. coli and enzymic properties
21. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B
22. Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein
23. Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage
24. Degradation of proteoglycan aggregate by a cartilage mettaloproteinase. Evidence for the involvement of stromelysin in the degradation of link protein heterogeneity in situ
25. Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage
26. Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility
27. Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity
28. 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites
29. Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
30. A semicontinuous, high-performance liquid chromatography-based assay for stromelysin
31. Matrix metalloproteinasees degrade insulin-like growth factor-binding protein- 1 in dermal fibroblast cultures
32. Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling
33. Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens
34. Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases
35. Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): Hydrolysis of the gGly404-Ala405 peptide bond
36. Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7, and - 9
37. Direct activation of human neutrophil procollagenase by recombinant stromelysin
38. Biochemical characterization of human collagenase-3
39. Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and 4-aminophenyl mercuric acetate
40. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9
41. Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)
42. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme
43. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
44. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
45. Immunophenotyping of childhood astrocytomas with a library of monoclonal antibodies
46. Immunoalkaline phosphatase cytochemistry
47. Diagnostic significance of levamisole-resistant alkaline phosphatase in cytochemistry and immunocytochemistry
48. The avidin-biotin reaction as an universal amplification system in immunoassays
49. Introduction to avidin-biotin technology
50. Prevention of nonspecific binding of avidin
51. The biotin-(strept)avidin system: Principles and applications in biotechnology
52. Difference in gene expression for matrix metalloproteinase- 1 between early and advanced hepatocellular carcinomas
53. In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis
54. Localization of messenger RNA for tissue inhibitor of metalloproteinases-1 and type IV collagenases/gelatinases in monkey hepatocellular carcinomas
55. Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential
56. Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors
57. Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas
58. Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers