Cytotoxic activity of polyprenylalcohols and vitamin K2 derivatives

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4307-4313

  Ishihara, M ^a   Takayama, F ^a   Toguchi, M ^a   Nakano, K ^a   Yasumoto, E ^a   Nakayachi, T ^a   Satoh, K ^a   Sakagami, H ^a  

^a MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

Cytotoxicity; DNA fragmentation; ESR; GGO; Human oral tumor cells; Polyprenylalcohol; Radical; Vitamin K2

Indexed keywords

ASCORBIC ACID; CYTOTOXIC AGENT; DNA FRAGMENT; FARNESOL; FARNESYLFARNESOL; FARNOQUINONE DERIVATIVE; GERANIOL; GERANYLFARNESOL; GERANYLFARNESYLFARNESOL; GERANYLGERANIOL; GERANYLGERANYLFARNESOL; HYPOXANTHINE; OXYGEN RADICAL; POLYPRENYLALCOHOL DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ELECTRON SPIN RESONANCE; FEMALE; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; HYDRATION; HYDROPHOBICITY; MOLECULAR WEIGHT; MOUTH TUMOR; PRIORITY JOURNAL; SCHOOL CHILD;

APOPTOSIS; CELL LINE; DITERPENES; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; FARNESOL; GEFARNATE; HUMANS; TERPENES; TUMOR CELLS, CULTURED; VITAMIN K;

EID: 0034480695     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Inhibition of epigallocatechin gallate-induced apoptosis by CoCl2 in human oral tumor cell lines
2. Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines. A possible mechanism
3. Induction of apoptosis by flavones, flavonols (3-hydroxylflavones) and isoprenoid-substituted flavonoids in human oral tumor cell lines
4. Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines
5. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines
6. Induction of apoptosis in various tumor cell lines by geranylgeraniol
7. Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U-937 cells
8. 2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis
9. 2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid
10. 2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: Flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody
11. The requirement for and mobilization of calcium during induction by sodium ascorbate and by hydrogen peroxide of cell death
12. Endonuclease activity and induction of DNA fragmentation in human myelogenous leukemic cell lines
13. Effect of an iron-chelator on ascorbate-induced cytotoxicity
14. Interaction between sodium ascorbate and dopamine
15. Detection of drug-drug interaction by ESR spectroscopy
16. Geranylgeraniol causes a decrease in levels of calreticulin and tyrosine phosphorylation of a 36kDa protein prior to the appearance of apoptotic features in HL-60 cells
17. Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL-60 cells
18. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells
19. Biological activity of Kiwifruit extracts
20. Apoptosis-inducing activity of vitamin C and vitamin K
21. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
22. Chromatin structure and endonuclease sensitivity in human leukemic cell lines