The Dlx3 protein harbors basic residues required for nuclear localization, transcriptional activity and binding to Msx1

Journal of Cell Science

Volumn 113, Issue 22, 2000, Pages 4013-4023

  Bryan, J T ^a   Morasso, M I ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

Bipartite nuclear localization signal; Dlx3; DNA binding; Homeodomain; Transactivation

Indexed keywords

CALCIUM ION; CYTOPLASM PROTEIN; DNA; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; KERATIN; PROTEIN DLX3; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MSX1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; EPIDERMIS; EPITHELIUM; GENE INSERTION; HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; TISSUE DIFFERENTIATION; TISSUE GROWTH; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; BINDING SITES; CELL NUCLEUS; CELLS, CULTURED; CLONING, MOLECULAR; FUNGAL PROTEINS; HOMEODOMAIN PROTEINS; KERATINOCYTES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MSX1 TRANSCRIPTION FACTOR; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SKIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; MURINAE;

EID: 0034474291     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Interneuron migration from basal forebrain to neocortex: Dependence on Dlx gene
2. Roles for Msx and Dlx homeoproteins in vertebrate development
3. Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex
4. Nuclear localization signals DNA binding, and transactivation properties of Quail Pax-6 (Pax-QNR) Isoforms
5. Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of 3 murine homeodomain proteins
6. Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites
7. The function and evolution of Msx genes: Pointers and paradoxes
8. Nuclear targeting sequences - A consensus?
9. Transcription factor regulation of epidermal keratinocyte gene expression
10. Transcriptional activation by the homeodomain protein Distal-less 3
11. The epidermis: Rising to the surface
12. Homeodomain proteins
13. Homeodomain-DNA recognition
14. Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells
15. Calcium regulation of growth and differentiation of mouse epidermal cells in culture
16. A new family of mouse homeo box-containing genes: Molecular structure, chromosomal location and developmental expression of Hox-7.1
17. Nuclear transport factors: Function, behavior and interaction
18. Transport of macromolecules between the nucleus and the cytoplasm
19. Nuclear targeting by growth factors, cytokines, and their receptors: A role in signaling?
20. Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tissue-specifying homeobox gene product Csx/Nkx2.5
21. Crystal structure of an engrailed homoedomain-DNA complex at 2.8 A resolution: A framework for understanding homeodomain-DNA interactions
22. DNA binding specificity of homeodomains
23. Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture
24. Mapping functional specificity in the Dfd and Ubx homeo-domains
25. The conserved ELK-homeodomain of KNOTTED-1 contains two regions that signal nuclear localization
26. Placental failure in mice lacking the homeobox gene Dlx3
27. A Xenopus distal-less gene in transgenic mice: Conserved regulation in distal limb epidermis and other sites of epithelial-mesenchymal interaction
28. Regulation of epidermal differentiation by Distal-less homeodomain gene
29. Identification of a mutation in Dlx3 associated with tricho-dento-osseous (TDO) syndrome
30. Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: Mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived arches
31. Differential and overlapping domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development
32. Differentiation of Vertebrate Epidermis
33. The structure and function of the homeodomain
34. Alterations in NFkB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NFkB
35. Design of a 'minimAl' homeodomain: The N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure
36. Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6
37. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro
38. A role for the Msx-1 homeodomain in transcriptional regulation: Residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression
39. Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism