Thymidylate synthase inhibition induces p53 dependent and independent cell death

Advances in Experimental Medicine and Biology

Volumn 486, Issue , 2000, Pages 303-306

  Backus, H H J ^a   Wouters, D ^a   Van der Wilt, C L ^a   Kuiper, C M ^a   Van Groeningen, C J ^a   Pinedo, H M ^a   Peters, G J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; NOLATREXED; PEMETREXED; PROTEIN P53; RALTITREXED; THYMIDYLATE SYNTHASE;

CANCER CELL CULTURE; CELL DEATH; CONFERENCE PAPER; DNA DAMAGE; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CASPASE 3; CASPASES; COLONIC NEOPLASMS; DNA DAMAGE; ENZYME INHIBITORS; FAS LIGAND PROTEIN; FLUOROURACIL; FOLIC ACID ANTAGONISTS; GLUTAMATES; GUANINE; HUMANS; MEMBRANE GLYCOPROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINAZOLINES; THIOPHENES; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034474152     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (10)

1. Folate-based thymidylate synthase inhibitors in cancer chemotherapy
2. New antimetabolites in preclinical and clinical development
3. P53, guardian of the genome
4. Regulators of cell death
5. Apoptosis by death factor
6. Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines
7. Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor Tomudex
8. The role of thymidylate synthase as an RNA binding protein
9. Mechanisms of acquired resistance to thymidylate synthase inhibitors: The role of enzyme stability
10. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo