In vivo silencing of the human γ-globin gene in murine erythroid cells following retroviral transduction

Blood Cells, Molecules, and Diseases

Volumn 26, Issue 6, 2000, Pages 613-619

  Lung, Hui yu ^a   Meeus, Ilse S ^a   Weinberg, Rona S ^a   Atweh, George F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; FATTY ACID; HEMOGLOBIN F; HYDROXYUREA; IMMUNOGLOBULIN; SHORT CHAIN FATTY ACID; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ERYTHROID CELL; ERYTHROLEUKEMIA; GENE CLUSTER; GENE EXPRESSION; GENE SILENCING; GENE THERAPY; GENETIC TRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; VECTOR CONTROL;

MURINAE; MUS MUSCULUS;

EID: 0034472742     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2000.0343     Document Type: Article

References (36)

1. Effect of hydroxyurea on the frequency of painful crisis in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in sickle cell anemia
2. Effects of DNA replication inhibitors on UV excision repair in synchronised human cells
3. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease
4. Monoclonal antibodies to αVβ3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor
5. Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease
6. Bone marrow transplantation for sickle cell disease
7. Design of retrovirus vectors for transfer and expression of the human β-globin gene
8. A human β-globin gene fused to the human β-globin locus control region is expressed at high levels in erythroid cells of mice engrafted with retrovirus-transduced hematopoietic stem cells
9. A majority of mice show long-term expression of a human β-globin gene after retrovirus transfer into hematopoietic stem cells
10. Expression of the human β-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice
11. Participation of hemoglobins A and F in polymerization of sickle hemoglobin
12. Production of genetically stable high-titer retroviral vectors that carry a human γ-globin gene under the control of the α-globin locus control region
13. High-level β-globin expression after retroviral transfer of locus activation region-containing human β-globin gene derivatives into murine erythroleukemia cells
14. Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: Evidence for a pre-CFU-S cell?
15. Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells
16. Stem cell factor, interleukin-3, and Interleukin-6 promote retroviral-mediated gene transfer into murine hematopoietic stem cells
17. Endogenous growth factor patterns modulate hemopoietic lineage development
18. Formation of factor-independent multilineage colonies after Abelson virus infection
19. Early detection of hematopoietic engraftment in murine bone marrow transplantation utilizing hemoglobin electrophoretic differences
20. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation
21. Aγ enhancer
22. Differences in human α-, β- and γ-globin gene expression in monkey kidney cells
23. Cis and trans activation of globin gene transcription in transient assays
24. Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences
25. Promoter sequences required for function of the human γ-globin gene in erythroid cells
26. Developmental regulation of human globin genes in transgenic mice
27. Erythroid-specific expression of human β-globin gene in transgenic mice
28. Expression of the human β-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells
29. Mutagenesis of retroviral vectors transducing human β-globin gene and β-globin locus control region derivatives results in stable transmission of an active transcriptional structure
30. Generation of a hightiter retroviral vector capable of expressing high levels of the human β-globin gene
31. Efficient hematopoietic stem cell transduction with β-globin retroviral vectors following longer ex vivo culture with growth factors
32. Developmental regulation of human γ-globin genes in transgenic mice
33. Gγ-globin and downstream β-globin sequences required for stage-specific expression in transgenic mice
34. Toward a transgenic mouse model of sickle cell disease: Hemoglobin SAD
35. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease
36. Knockout-transgenic mouse model of sickle cell disease