The serotonergic appetite suppressant fenfluramine: Reappraisal and rejection

Advances in Experimental Medicine and Biology

Volumn 467, Issue , 2000, Pages 95-100

  Curzon, G ^a   Gibson, E L ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FENFLURAMINE; PHENTERMINE; SEROTONIN;

APPETITE; CARDIOTOXICITY; CONFERENCE PAPER; DRUG MECHANISM; HUMAN; OBESITY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SEROTONIN BRAIN LEVEL;

APPETITE; BRAIN; CARDIOVASCULAR DISEASES; FENFLURAMINE; HUMANS; PHENTERMINE; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 0034468451     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Influence of tryptophane on appetite and food selection in man
2. d-fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain
3. The use of pharmacokinetics in the assessment of dexfenfluramine safety
4. The pharmacokinetics of dexfenfluramine in obese and non-obese subjects
5. Fenfluramine and norfenfluramine levels in brain microdialysate brain tissue and plasma of rats administered doses of d-fenfluramine known to deplete 5-hydroxytryptamine levels in brain
6. Valvular heart disease associated with phenfluramine phentermine
7. Characterization of 5-HT receptors in human pulmonary artery and vein: Functional and binding studies
8. Serotonergic aspects of feeding
9. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability
10. The effect of D-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats
11. d-fenfluramine and d-norfenfluramine induced hypophagia: Differential mechanisms and involvement of postsynaptic 5-HT receptors
12. Further cases of valvular heart disease associated with fenfluramine-Phentermine
13. 1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y
14. International trial of long term dexfenfluramine in obesity
15. 1B receptor agonist CP-94,153 reduces food intake and preserves the behavioural satiety sequence
16. Increased plasma serotonin in primary pulmonary hypertension
17. 1B agonists induce anorexia at a postsynaptic site
18. Regional adiposity and morbidity
19. Hypothalamic serotonin: Pharmacological, biochemical and behavioural analyses of its feeding-Suppressive action
20. Combined phentermine/fenfluramine administration enhances depletion of serotonin from central terminal fields
21. Absence of fenfluramine-induced anorexia and reduced C-fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B knock-out mice
22. A placebo-controlled, dose-response study of dexfluramine in the treatment of these patients
23. Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence
24. Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs
25. Long-term pharmacotherapy in the management of obesity
26. 1 receptors
27. d-fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release
28. Effects of d-fenfluramine on feeding and hypothalamic 5-hydroxytryptamine and dopamine in male and female rats
29. In vitro and in vivo effects of d-fenfluramine: No apparent relation between 5-hydroxytryptamine release and hypophagia
30. Role of 5-HT receptors in the effect of d-fenfluramine on gastric emptying and feeding behaviour as examined in the running test
31. Overview of the clinical data
32. An analysis of weight and diet content in five women's interest magazines
33. Changes in macronutrient selection as a function of dietary tryptophan
34. Cultural expectations of thiness in women: An update