메뉴 건너뛰기




Volumn 26, Issue 1, 1997, Pages 36-45

Combined phentermine/fenfluramine administration enhances depletion of serotonin from central terminal fields

Author keywords

neuronal degeneration; neurotoxicity; obesity; weight reduction

Indexed keywords

CARRIER PROTEIN; FENFLURAMINE; PHENTERMINE; SEROTONIN; SEROTONIN TRANSPORTER;

EID: 0030898124     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199705)26:1<36::AID-SYN4>3.0.CO;2-F     Document Type: Article
Times cited : (17)

References (34)
  • 1
    • 0001776175 scopus 로고
    • Pathways of drug metabolism
    • ed. W.B. Pratt and P. Taylor, Churchill Livingstone, New York
    • Alvares, A.P., and Pratt, W.B. (1990) Pathways of drug metabolism. In: Principles of Drug Action: The Basis of Pharmacology, ed. W.B. Pratt and P. Taylor, Churchill Livingstone, New York, pp. 365-422.
    • (1990) Principles of Drug Action: The Basis of Pharmacology , pp. 365-422
    • Alvares, A.P.A.1    Pratt, W.B.2
  • 2
    • 0024360136 scopus 로고
    • Fen selectively and differentially decreases the density of serotonergic nerve terminals in rat brain: Evidence from immunocytochemical studies
    • Appel, N.M., Contrera, J.F., and De Souza, E.B. (1989) Fen selectively and differentially decreases the density of serotonergic nerve terminals in rat brain: Evidence from immunocytochemical studies. J. Pharmacol. Exp. Ther., 249:928-943.
    • (1989) J. Pharmacol. Exp. Ther. , vol.249 , pp. 928-943
    • Appel, N.M.1    Contrera, J.F.2    De Souza, E.B.3
  • 3
    • 0025090790 scopus 로고
    • Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: Assessment using quantitative autoradiography
    • Appel, N.M., Mitchell, W.M., Contrera, J.F., and De Souza, E.B. (1990) Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: Assessment using quantitative autoradiography. Synapse, 6:33-44.
    • (1990) Synapse , vol.6 , pp. 33-44
    • Appel, N.M.1    Mitchell, W.M.2    Contrera, J.F.3    De Souza, E.B.4
  • 4
    • 0027989865 scopus 로고
    • Report on the NIH workshop on pharmacologic treatment of obesity
    • Atkinson, R.L., and Hubbard, V.S. (1994) Report on the NIH workshop on pharmacologic treatment of obesity. Am. J. Clin. Nutr., 60:153-156.
    • (1994) Am. J. Clin. Nutr. , vol.60 , pp. 153-156
    • Atkinson, R.L.1    Hubbard, V.S.2
  • 6
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
    • Battaglia, G., Yeh, S.Y., and De, S.E.B. (1988) MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons. Pharmacol. Biochem. Behav. 29:269-274.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    De, S.E.B.3
  • 9
    • 0017083601 scopus 로고
    • Anorectic drugs: Use in general practice
    • Craddock, D. (1976) Anorectic drugs: Use in general practice. Drugs, 11:378-393.
    • (1976) Drugs , vol.11 , pp. 378-393
    • Craddock, D.1
  • 10
    • 0013909023 scopus 로고
    • Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man
    • Freireich, E.J., Gehan, E.A., Rail, D.P., Schmidt, L.H., and Skipper, H.E. (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Cherother. Rep. 50:219-226.
    • (1966) Cancer Cherother. Rep. , vol.50 , pp. 219-226
    • Freireich, E.J.1    Gehan, E.A.2    Rail, D.P.3    Schmidt, L.H.4    Skipper, H.E.5
  • 11
    • 0016682258 scopus 로고
    • Fenfluramine: Evidence for a neurotoxic action on a long-term depletion of serotonin
    • Harvey, J.A., and McMaster, S.E. (1975) Fenfluramine: Evidence for a neurotoxic action on a long-term depletion of serotonin. Psychopharmacol. Commun., 1:217-228.
    • (1975) Psychopharmacol. Commun. , vol.1 , pp. 217-228
    • Harvey, J.A.1    McMaster, S.E.2
  • 12
    • 0017729454 scopus 로고
    • Fenfluramine: Cumulative neurotoxicity after chronic treatment with low dosages in the rat
    • Harvey, J.A. and McMaster, S.E. (1977) Fenfluramine: Cumulative neurotoxicity after chronic treatment with low dosages in the rat. Commun. Psychopharmacol., 1:3-17.
    • (1977) Commun. Psychopharmacol. , vol.1 , pp. 3-17
    • Harvey, J.A.1    McMaster, S.E.2
  • 13
    • 0017704594 scopus 로고
    • Comparison between the neurotoxic and serotonin depleting effects of various halogenated derivatives of amphetamine in the rat
    • Harvey, J.A., McMaster, S.E., and Fuller, R.W. (1977) Comparison between the neurotoxic and serotonin depleting effects of various halogenated derivatives of amphetamine in the rat. J. Pharmacol. Exp. Ther., 202:581-589.
    • (1977) J. Pharmacol. Exp. Ther. , vol.202 , pp. 581-589
    • Harvey, J.A.1    McMaster, S.E.2    Fuller, R.W.3
  • 14
  • 15
    • 0028557961 scopus 로고
    • Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ("ecstasy") to rats
    • Hewitt, K.E., and Green, A.R. (1994) Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ("ecstasy") to rats. Neuropharmacology, 33:1589-1595.
    • (1994) Neuropharmacology , vol.33 , pp. 1589-1595
    • Hewitt, K.E.1    Green, A.R.2
  • 16
    • 0024951451 scopus 로고
    • Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications
    • Hoebel, B.C., Hernandez, L., Schwartz, D.H., Mark, G.P., and Hunter, G.A. (1989) Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications. Ann. N.Y. Acad. Sci., 575:171-191.
    • (1989) Ann. N.Y. Acad. Sci. , vol.575 , pp. 171-191
    • Hoebel, B.C.1    Hernandez, L.2    Schwartz, D.H.3    Mark, G.P.A.4    Hunter, G.A.5
  • 17
    • 0024788704 scopus 로고
    • D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain
    • Kleven, M.S., and Seiden, L.S. (1989) D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain. Brain Res., 505:351-353.
    • (1989) Brain Res. , vol.505 , pp. 351-353
    • Kleven, M.S.1    Seiden, L.S.2
  • 18
    • 0023724530 scopus 로고
    • Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine
    • Kleven, M.S., Schuster, C.R., and Seiden, L.S. (1988) Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine. J. Pharmacol. Exp. Ther. 246:822-828.
    • (1988) J. Pharmacol. Exp. Ther. , vol.246 , pp. 822-828
    • Kleven, M.S.1    Schuster, C.R.2    Seiden, L.S.3
  • 19
    • 0007397241 scopus 로고
    • Evaluation of potential neurotoxic effects of amphetamine-related anorectic agents on brain serotonin and dopamine in the rat
    • Kleven, M.S., Woolverton, W.L., and Seiden, L.S. (1991) Evaluation of potential neurotoxic effects of amphetamine-related anorectic agents on brain serotonin and dopamine in the rat. Proc. Soc. Neurosci., 17:1488.
    • (1991) Proc. Soc. Neurosci. , vol.17 , pp. 1488
    • Kleven, M.S.1    Woolverton, W.L.2    Seiden, L.S.3
  • 20
    • 0025014798 scopus 로고
    • Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat
    • Molliver, D.C., and Molliver, M.E. (1990) Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat. Brain Res., 511:165-168.
    • (1990) Brain Res. , vol.511 , pp. 165-168
    • Molliver, D.C.1    Molliver, M.E.2
  • 21
    • 0019061918 scopus 로고
    • LIGAND: A versatile approach for characterization of ligand-binding systems
    • Munson, P.J., and Rodbard, D. (1980) LIGAND: A versatile approach for characterization of ligand-binding systems. Anal. Biochem., 107:220-239.
    • (1980) Anal. Biochem. , vol.107 , pp. 220-239
    • Munson, P.J.1    Rodbard, D.2
  • 22
    • 0002538201 scopus 로고    scopus 로고
    • Dose-time-effect relationships
    • R.J.M. Niesink, J. de. Vries, and M.A. Hollinger, eds. CRC Press, Boca Raton, New York, London, and Tokyo
    • Musch, A. (1996) Dose-time-effect relationships. In: Toxicology: Principles and Applications. R.J.M. Niesink, J. de. Vries, and M.A. Hollinger, eds. CRC Press, Boca Raton, New York, London, and Tokyo, pp 187-237.
    • (1996) Toxicology: Principles and Applications , pp. 187-237
    • Musch, A.1
  • 23
    • 0028061499 scopus 로고
    • Multiple serotonin receptors: Clinical and experimental aspects
    • Roth, B.L. (1994) Multiple serotonin receptors: Clinical and experimental aspects. Ann. Clin. Psychiatry, 6:67-78.
    • (1994) Ann. Clin. Psychiatry , vol.6 , pp. 67-78
    • Roth, B.L.1
  • 27
    • 0026680624 scopus 로고
    • Appetite suppressants. A review
    • Silverstone, T. (1992) Appetite suppressants. A review. Drugs, 43:820-836.
    • (1992) Drugs , vol.43 , pp. 820-836
    • Silverstone, T.1
  • 28
    • 0026593859 scopus 로고
    • Long-term weight control study: Conclusions
    • Weintraub, M.D., (1992) Long-term weight control study: Conclusions. Clin. Pharmacol. Ther., 51:642-646.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 642-646
    • Weintraub, M.D.1
  • 29
    • 0021242404 scopus 로고
    • A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination
    • Weintraub, M.D., Hasday, J.D., Mushlin, A.I., and Lockwood, D.H. (1984) A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination. Arch. Intern. Med., 144:1143-1148.
    • (1984) Arch. Intern. Med. , vol.144 , pp. 1143-1148
    • Weintraub, M.D.1    Hasday, J.D.2    Mushlin, A.I.3    Lockwood, D.H.4
  • 30
    • 0026518794 scopus 로고
    • Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo
    • Weintraub, M.D., Sundaresan, P.R., Madan, M., Schuster, B., Balder, A., Lasagna, L., and Cox. C. (1992a) Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo. Clin. Pharmacol. Ther., 51:586-594.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 586-594
    • Weintraub, M.D.1    Sundaresan, P.R.2    Madan, M.3    Schuster, B.4    Balder, A.5    Lasagna, L.6    Cox, C.7
  • 31
    • 0026589037 scopus 로고
    • Long-term weight control study. V (weeks 190 to 210). Follow-up of participants after cessation of medication
    • Weintraub, M.D., Sundaresan, P.R., Schuster, B., Averbuch, M., Stein, E.C., and Byrne, L. (1992b) Long-term weight control study. V (weeks 190 to 210). Follow-up of participants after cessation of medication. Clin. Pharmacol. Ther., 51:615-618.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 615-618
    • Weintraub, M.D.1    Sundaresan, P.R.2    Schuster, B.3    Averbuch, M.4    Stein, E.C.5    Byrne, L.6
  • 33
    • 0026593857 scopus 로고
    • Long-term weight control study. II (weeks 34 to 104). An open-label study of continuous fenfluramine plus phentermine versus targeted intermittent medication as adjuncts to behavior modification, caloric restriction, and exercise
    • Weintraub, M.D., Sundaresan, P.R., Schuster, B., Ginsberg, G., Madan, M., Balder, A., Stein, E.C., and Byrne, L. (1992d) Long-term weight control study. II (weeks 34 to 104). An open-label study of continuous fenfluramine plus phentermine versus targeted intermittent medication as adjuncts to behavior modification, caloric restriction, and exercise. Clin. Pharmacol. Ther. 51:595-601.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 595-601
    • Weintraub, M.D.1    Sundaresan, P.R.2    Schuster, B.3    Ginsberg, G.4    Madan, M.5    Balder, A.6    Stein, E.C.7    Byrne, L.8
  • 34
    • 0026531965 scopus 로고
    • Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine
    • Weintraub, M.D., Sundaresan, P.R., Schuster, B., Moscucci, M., and Stein, B.C. (1992e) Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine. Clin. Pharmacol. Ther. 51:602-607.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 602-607
    • Weintraub, M.D.1    Sundaresan, P.R.2    Schuster, B.3    Moscucci, M.4    Stein, B.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.