Evidence of a no-effect level in silica-induced rat lung mutagenicity but not in fibrogenicity

Archives of Toxicology

Volumn 74, Issue 11, 2001, Pages 716-719

  Seiler, Frank ^a,b   Rehn, Bernd ^a,c   Rehn, Stefanie ^a   Bruch, Joachim ^a  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^b Squarix Biotechnology   (Germany)

^c IBE   (Germany)

Author keywords

8 Oxoguanine; Fibrogenicity; Mutagenicity; No effect level; Quartz; Rat

Indexed keywords

8 HYDROXYGUANINE; CARCINOGEN; DNA; LUNG SURFACTANT; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; FIBROGENESIS; INFLAMMATION; LUNG CANCER; LUNG CARCINOGENESIS; LUNG FIBROSIS; LUNG LAVAGE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; TOXICOKINETICS;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENES, P53; GUANINE; IMAGE CYTOMETRY; INTUBATION, INTRATRACHEAL; LUNG; MUTAGENS; MUTATION; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PULMONARY FIBROSIS; PULMONARY SURFACTANTS; QUARTZ; RATS; RATS, WISTAR; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0034465935     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000191     Document Type: Article

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