Regulation of cyclooxygenase-2 by the activated p38 MAPK signaling pathway

Advances in Experimental Medicine and Biology

Volumn 469, Issue , 2000, Pages 9-15

  Guan, Z ^a   Buckman, S Y ^a   Springer, L D ^a   Morrison, A R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPYRETIC ANALGESIC AGENT; CYCLOOXYGENASE 2; ENDOTOXIN; GROWTH FACTOR; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR;

ANTIINFLAMMATORY ACTIVITY; COLON CANCER; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME REGULATION; GENE EXPRESSION; INFLAMMATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SODIUM URINE LEVEL; WATER ABSORPTION;

3T3 CELLS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME ACTIVATION; GLOMERULAR MESANGIUM; INTERLEUKIN-1; ISOENZYMES; ISOPROPYL THIOGALACTOSIDE; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0034463315     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (17)

1. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
2. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells
3. Mitogen-inducible prostaglandin G/H synthase: A new target for nonsteroidal anti-inflammatory drugs
4. Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase
5. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase
6. Interactions of PGH synthase isozymes-1 and -2 with NSAIDs
7. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
8. Aspirin and the potential role of prostaglandins in colon cancer
9. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent
10. A protein kinase involved in the regulation of inflammatory, cytokine biosynthesis
11. The stress-activated protein kinase subfamily of c-Jun kinases
12. cPla2 is phosphorylated and activated by Map kinase
13. p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPla2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPla2
14. 2-terminal kinase subgroup of mitogen-activated protein kinases in mesangial cells
15. p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E(2) biosynthesis stimulated by interleukin-1-beta
16. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
17. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms