The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan

Cephalalgia

Volumn 20, Issue 6, 2000, Pages 538-545

  Maassen Van Den Brink, A ^a   Van Den Broek, R W M ^a   De Vries, R ^a   Upton, N ^a,b   Parsons, A A ^a,b   Saxena, P R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Coronary artery; Human; Middle meningeal artery; Migraine; Myocardium; Saphenous vein; SB 220453; Sumatriptan

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 6 ACETYL 4 (3 CHLORO 4 FLUOROBENZOYLAMINO) 3,4 DIHYDRO 2,2 DIMETHYL 2H 1 BENZOPYRAN 3 OL; ANTIMIGRAINE AGENT; SUMATRIPTAN; TONABERSAT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; FEMALE; HEART ATRIUM MUSCLE; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; MALE; MENINGEAL ARTERY; SAPHENOUS VEIN; SMOOTH MUSCLE CONTRACTILITY; VASOCONSTRICTION;

ADULT; AGED; ANALGESICS; BENZAMIDES; BENZOPYRANS; CORONARY VESSELS; DRUG EVALUATION, PRECLINICAL; FEMALE; HEART ATRIA; HEART VENTRICLES; HUMANS; MALE; MENINGEAL ARTERIES; MIDDLE AGED; MYOCARDIAL CONTRACTION; NOREPINEPHRINE; SAPHENOUS VEIN; SUMATRIPTAN; VASOCONSTRICTION;

EID: 0034453877     PISSN: 03331024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-2982.2000.00078.x     Document Type: Article

References (37)

1. The safety and tolerability of sumatriptan: An overview
2. ID agonist
3. Sumatriptan in clinical practice: A 2-year review of 453 migraine patients
4. Is chest pain after sumatriptan oesophageal in origin?
5. 1 agonist, on the systemic, pulmonary, and coronary circulation
6. 2 receptor activation
7. Sumatriptan and ischaemic heart disease
8. Sumatriptan and ischaemic heart disease
9. Coronary side-effect potential of current and prospective antimigraine drugs
10. Acute myocardial infarction induced by ergotamine tartrate: Possible role of coronary arterial spasm
11. Myocardial ischemia related to ergot alkaloids: A case report and literature review
12. Oral sumatriptan-associated transmural myocardial infarction
13. Transmural myocardial infarction with sumatriptan
14. Cardiac arrest following use of sumatriptan
15. ID receptor agonists in development for the acute treatment of migraine
16. Human middle meningeal and coronary artery contraction to eletriptan and sumatriptan
17. Comparison of the cardiovascular effects of the novel 5-HT(1B/1D) receptor agonist, SB 209509 (VML251), and sumatriptan in dogs
18. Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2- dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent
19. SB-220453, a mechanistically novel benzopyran compound, inhibits trigeminal nerve ganglion (TGN) stimulation-induced carotid vasodilatation
20. SB-220453 inhibits cortical spreading depression (SD) associated NO release in the anaesthetised cat
21. ID-like receptors, and a comparison with grafted veins
22. 1-like receptor
23. 5-Hydroxytryptamine receptor characterization of human cerebral, middle meningeal and temporal arteries: Regional differences
24. Different pharmacological responses of atrium and ventricle: Studies with human cardiac tissue
25. Augmented contraction of the human isolated coronary artery by sumatriptan; a possible role for endogenous thromboxane
26. Human isolated coronary artery contraction to sumatriptan; a post hoc analysis
27. Different interactions of platelets with arterial and venous coronary bypass vessels
28. Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries
29. Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5′-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta
30. Vasoconstriction by in situ formed angiotensin II: Role of ACE and chymase
31. Characterisation of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques
32. The haemodynamic effects of subcutaneous sumatriptan, a 5HTI-receptor agonist
33. Characterization of the 5-hydroxytryptamine receptor mediating the positive inotropic response in guinea-pig isolated left atria
34. Effects of sumatriptan, on coronary flow and left ventricular function in the isolated perfused guinea pig heart
35. Effects of sumatriptan on isolated rabbit heart
36. 5-Hydroxytryptamine: A chameleon in the heart
37. Inhibition of noradrenaline release via presynaptic 5-HTID alpha receptors in human atrium