Interleukin-1 receptor antagonist ribonucleic acid and protein expression by cultured Graves' and normal orbital fibroblasts is differentially modulated by dexamethasone and irradiation

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 2, 2000, Pages 734-742

  Muhlberg T ^a   Joba, W ^a   Spitzweg, C ^a   Schworm, H D ^a   Heberling, H J ^a   Heufelder, A E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MIFEPRISTONE; RECOMBINANT INTERLEUKIN 1ALPHA; RNA;

ARTICLE; CONTROLLED STUDY; EXTRAOCULAR MUSCLE; EYE DISEASE; FIBROBLAST; GRAVES DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; IONIZING RADIATION; ORBIT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE;

CELLS, CULTURED; DEXAMETHASONE; FIBROBLASTS; GLUCOCORTICOIDS; GRAVES DISEASE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTRACELLULAR MEMBRANES; ORBIT; REFERENCE VALUES; RNA; SIALOGLYCOPROTEINS; SOLUBILITY;

EID: 0034453091     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.2.734     Document Type: Article

References (40)

1. Retro-orbital autoimmunity
2. Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue
3. Immunohistochemical staining of normal and Graves' extraocular muscle
4. Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy
5. + and specifically recognize autologous fibroblasts
6. Detection and localization of cytokine immtmoreactivity in retroocular connective tissue in Graves' ophthalmopathy
7. Somatomedin C in pathogenesis of malignant exophthalmos of endocrine origin
8. Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts
9. Mechanisms of disease: Graves' ophthalmopathy
10. Interleukin-1 and interleukin-1 antagonism
11. Interleukin 1, a potential regulator of fibroblast proliferation
12. Interleukin 1 receptor antagonist
13. Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro
14. Interleukin-1 receptor antagonist
15. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
16. cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium
17. Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist
18. Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibir IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts
19. Detection and modulation of interleukin-1 receptor antagonist messenger ribonucleic acid and immunoreactivity in Graves' orbital fibroblasts
20. Treating severe Graves' ophthalmopathy
21. Randomised double-blind trial of prednisone vs. radiotherapy in Graves' ophthalmopathy
22. Soluble interleukin-1 receptor antagonist serum levels in smokers and nonsmokers with Graves' ophthalmopathy undergoing orbital radiotherapy
23. Human retroocular fibroblasts in vitro: A model for the study of Graves' ophthalmopathy
24. Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts
25. Increased induction of HLA-DR by mterferon-γ in cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial dermopathy
26. Elevated expression in situ of selectin and immunoglobulin superfamily type adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy
27. The effects of interleukin-1β (IL-1β) on human thyrocyte functions are counteracted by the IL-1 receptor antagonist
28. Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin
29. Rabbit interleukin-1 receptor antagonist. Cloning, expression, functional characterization, and regulation during intestinal inflammation
30. Inhibition of lipopolysaccharide-induced monocyte interleukin-1 receptor antagonist synthesis by cortisol: Involvement of the mineralocorticoid receptor
31. Dexamethasone antagomzes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4-, IL-10-, and TGF-β- induced suppression of TNF-α release
32. The combination of endotoxin and dexamethasone induces type II interleukin I receptor (IL-1R II) in monocytes: A comparison to interleukin 1β (IL-1β) and interleukin 1 receptor antagonist (IL-1ra)
33. Corticosteroids inhibit murine macrophage Ia expression and interleukin-1 production
34. Lipopolysaccharide increases glucocortiocid receptor expression in murine macrophages. A possible mechanism for glucocorticoid-mediated suppresion of endotoxicity
35. UV-irradiated epidermal cells produce a specific inhibitor of interleukin 1 activity
36. Elevation of interleukin 1 receptor antagonist in the stratum corneum of sun-exposed and ultraviolet B-irradiated human skin
37. Characterization of an interleukin 1 receptor antagonist protein released from ultraviolet-irradiated epidermal sheet
38. Interleukin-8 and melanoma growth-stimulating activity (GRO) are induced by ultraviolet B radiation in human keratinocyte cell lines
39. 3H-thymidine incorporation and the release of [3H]arachidonic acid in human monocytes
40. Irradiation increases levels of GM-CSF through RNA stabilization which requires an AU-rich region in cancer cells