Detection and modulation of interleukin-1 receptor antagonist messenger ribonucleic acid and immunoreactivity in Graves' orbital fibroblasts

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 5, 1997, Pages 1018-1028

  Mühlberg, Tina ^a,c   Heberling, Hans Jürgen ^c   Joba, Werner ^a   Schworm, Hermann Dieter ^b   Heufelder, Armin E ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Klinikum St Georg   (Germany)

Author keywords

cytokines; Graves' disease; immunomodulation; interleukin 1; thyroid associated ophthalmopathy

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MESSENGER RNA;

ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE EXPRESSION REGULATION; GRAVES DISEASE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; ORBIT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

CELL CULTURE TECHNIQUES; CYTOKINES; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENE EXPRESSION; GRAVES DISEASE; HUMANS; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIPOPOLYSACCHARIDES; ORBIT; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER; SIALOGLYCOPROTEINS; SOLUBILITY; TETRADECANOYLPHORBOL ACETATE;

EID: 0041082602     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Bahn RS, Heufelder AE. 1993 Mechanisms of disease: Graves' ophthalmopathy. N Engl J Med. 1993;329:1468-1475.
2. Hufnagel TJ, Hickey WF, Cobbs WH, Jacobiec FA, Eagle RC. Immunohistochemical and ultrastructural studies on the exenterated orbital tissue of a patient with Graves' disease. Ophthalmology. 1984;91:1411-1419.
3. Bahn RS, Heufelder AE. The role of connective tissue autoimmunity in Graves' ophthalmopathy. Autoimmunity. 1992;13:75-79.
4. Bahn RS, Heufelder AE. Retroocular fibroblasts - important effector cells in Graves' ophthalmopathy. Thyroid. 1992;2:89-94.
5. Weetman AP. Update: Thyroid-associated ophthalmopathy. Autoimmunity. 1992;12:215-222.
6. Korducki JM, Loftus SJ, Bahn RS. Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts. Invest Ophthalmol Vis Sci. 1992;33:209-214.
7. Heufelder AE, Smith TJ, Gorman CA, Bahn RS. Increased induction of HLA-DR by interferon-gamma in cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial dermopathy. J Clin Endocrinol Metab. 1991;73:307-313.
8. Heufelder AE, Bahn RS. Modulation of intercellular adhesion molecule-1 (ICAM-1) by cytokines and Graves' IgGs in cultured Graves' retroocular fibroblasts. Eur J Clin Invest. 1992;22:529-537.
9. Heufelder AE, Wenzel BE, Bahn RS. Cell surface localization of a 72 kDa heat shock protein in retroocular fibroblasts from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab. 1992;74:732-736.
10. Heufelder AE, Bahn RS. Detection and localization of cytokine immunoreactivity in retroocular connective tissue in Graves' ophthalmopathy. Eur J Clin Invest. 1993;23:10-17.
11. + and specifically recognize autologous fibroblasts. J Clin Invest. 1994;93:2738-2743.
12. Heufelder AE, Eggert K, Ernst G, Bahn RS, Scriba PC. Expression of cytokine and growth factor genes in cultured retroorbital fibroblasts from patients with Graves' ophthalmopathy. Program of the 76th Annual Meeting of The Endocrine Society. 1994:228 Abstract.
13. Dinarello C. Interleukin-1 and interleukin-1 antagonism. Blood. 1991;77:1627-1652.
14. Dinarello CA, Thompson RC. Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today. 1991;12:404-410.
15. Arend WP. Interleukin 1 receptor antagonist. J Clin Invest. 1991;88:1445-1451.
16. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol 1993;54:167-227.
17. Ye K, Clark BD, Dinarello CA. Interleukin-1β down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression. Immunology. 1992;75:427-434.
18. Ramadori G, Sipe JD, Dinarello CA, Mizel SB, Colten HR. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J Exp Med. 1985;162:930-937.
19. Navarro S, Debili N, Bernandin JF, Vainchenker W, Doly J. Regulation of the expression of IL-6 in human monocytes. J Immunol. 1989;142:4339-4345.
20. Herrmann F, Oster W, Meuer SC, Lindemann A, Mertelsmann RH. Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor. J Clin Invest. 1988;81:1415-1418.
21. Eisenberg SP, Evans RJ, Arend WP, et al. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature. 1990;343:341-346.
22. Haskill S, Martin G, Van Le L, et al. cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. Proc Natl Acad Sci USA. 1991;88:3681-3685.
23. Muzio M, Polentarutti N, Sironi M, et al. Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. J Exp Med. 1995;182:623-628.
24. Heufelder AE, Bahn RS. Modulation of cellular func- tions in retroorbital fibroblasts using antisense oligonucleotides targeting the c-myc protooncogene. Invest Ophthatmol Vis Sci. 1995;35:1420-1432.
25. Schmidt JA, Mizel SB, Cohen D, Green I. Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol. 1982;128:2177-2183.
26. Bahn RS, Gorman CA, Woloschak GE, David CS, Johnson PM, Johnson CM, Human retroocular fibroblasts in vitro: a model for the study of Graves' ophthalmopathy. J Clin Endocrinol Metab. 1987;65:665-670.
27. Heufelder AE, Bahn RS. Elevated expression in situ of selectin and immunoglobulin superfamily type adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy. Clin Exp Immunol. 1993;91:381-390.
28. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanat-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
29. Krzesicki RF, Hatfield CA, Bienkowski MJ, et al. Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts. J Immunol. 1993;150:4008-4018.
30. Weetman AP, Cohen S, Gatter KG, Fells D, Shine B. Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy. Clin Exp Immunol. 1989;75:222-227.
31. McLachlan SM, Prummel MF, Rapoport B. Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue. J Clin Endocrinol Metab. 1994;78:1070-1074.
32. Tallstedt L, Norberg R. Immunohistochemical staining of normal and Graves' extraocular muscle. Invest Ophthalmol Vis Sci. 1988;29:175-184.
33. Campbell R. Pathology in Graves' ophthalmopathy. In: Gorman CA, Waller, RA, Dyer JA, eds. The Eye and Orbit in Thyroid Disease. New York: Raven Press; 1984:25-31.
34. Weetman AP. Thyroid-associated eye disease: Pathophysiology. The Lancet. 1991;388:25-32.
35. Heufelder AE. Pathogenesis of Graves' ophthalmopathy: Recent controversies and progress. Eur J Endocrinol. 1995;132:532-541.
36. Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994;8:1314-1325.
37. Tan GH, Dutton CM, Bahn RS. Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab. 1996;81:449-452.
38. Firestein GS, Berger AE, Tracey DE, et al. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. J Immunol. 1992;149:1054-1062.
39. Turner M, Chantry D, Katsikis P, Berger A, Brennan FM, Feldmann M. Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-β. Eur J Immunol. 1991;21:1635-1639.
40. Jenkins JK, Malyak M, Arend WP. The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1β production in human monocytes and neutrophils. Lymphokine Cytokine Res. 1994;13:47-54.
41. Seitz M, Loetscher P, Dewald B, Towbin H, Ceska M, Baggiolini M. Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes-regulation by IFNγ and IL-4. J Immunol. 1994;152:2060-2065.
42. Kutsch CL, Morris DA, Arend WP. Tumor necrosis factor-α induces interleukin-1α and interleukin-1 receptor antagonist production by cultured human keratinocytes. J Invest Dermatol. 1993;101:79-85.
43. Firestein GS, Boyle DL, Yu C, et al. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 1994;37:644-652.
44. Bigler CF, Norris DA, Weston WL, Arend WP. Interleukin-1 receptor antagonist production by human keratinocytes. J Invest Dermatol. 1992;98:38-44.
45. Hammerberg C, Arend WP, Fisher GJ, et al. Interleukin-1 receptor antagonist in normal and psoriatic epidermis. J Clin Invest. 1992;90:571-583.
46. Lennard AC. Interleukin-1 receptor antagonist. Crit Rev Immunol. 1995;15:77-105.
47. Chikanza IC, Roux-Lombard P, Dayer JM, Panayi GS. Dysregulation of the in vivo production of interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:642-648.
48. Fujikawa Y, Shingu M, Torisu T, Masumi S. Interleukin-1 receptor antagonist production in cultured synovial cells from patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. 1995;54:318-320.
49. Firestein GS, Boyle DL, Yu C, et al. Synovial interleukin1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 1994;37:644-652.
50. Miller LC, Lynch EA, Isa S, Logan JW, Dinarello CA, Steere AC. Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis. Lancet. 1993;341:146-148.