Ukrain: A novel antitumor drug

Drugs under Experimental and Clinical Research

Volumn 26, Issue 5-6, 2000, Pages 341-356

  Uglyanitsa, K N ^a   Nefyodov, L I ^a   Doroshenko, Y M ^a   Nowicky, J W ^a   Volchek, I V ^a   Brzosko, W J ^a   Hodysh, Y J ^a  

^a GRODNO STATE MEDICAL UNIVERSITY   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DAUNORUBICIN; DOXORUBICIN; FLUOROURACIL; IMMUNOLOGIC AGENT; METISAZONE; RIMANTADINE; UKRAIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; CANCER REGRESSION; CHELIDONIUM; CLINICAL TRIAL; CYTOSTASIS; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG TOLERABILITY; FEMALE; HUMAN; LD 50; MALE; MOUSE; NONHUMAN; REVIEW; TUMOR CELL;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BERBERINE ALKALOIDS; HUMANS; NEOPLASMS; PHENANTHRIDINES;

EID: 0034446508     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (132)

1. Ukrain is selectively cytostatic and/or cytotoxic to human tumor and HIV-infected cells but not to human normal cells
2. Biological response-modifying properties of the alkaloid derivative Ukrain (NSC 631570)
3. Cancer immunotherapy using interleukin-2 and interleukin-2 activated lymphocytes
4. Increased T-helper lymphocytes following active specific intralymphatic immunotherapy of cancer
5. In vivo administration of purilied human interleukin-2. Half-life and immunologic effects of the Jurkat cell line-derived interleukin-2
6. α-Interferon in the treatment of modular lymphomas
7. Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator
8. The production of isoquinoline alkaloids by plant cell cultures
9. Ukrain in the treatment of urethral recurrent carcinoma
10. On a new method of treatment of the colon
11. Treatment of cancer by nipplewort or greater celandine (Chelidonium majus)
12. Ukrain antineoplastic immunostimulant. E09/029, NSC-631570, NSC-B238865, UKSR-222, W122
13. New immunostimulating anti-cancer preparation "Ukrain"
14. Cancer treatment using anticancer preparation alkaloid derivative Ukrain
15. Evaluation of clinical studies of Ukrain in cancer patients
16. Enhancement of cell mediated lysis on tumor cells by Chelidonium majus L. Alkaloids (Ukrain)
17. Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L.
18. Pharmacological effects of Ukrain in rats and rabbits
19. Some pharmacological properties of prolonged administration of Ukrain on rodents
20. Biological activity of Ukrain in vitro and in vivo
21. Evaluation of mutagenic, genotoxic and transforming properties of Ukrain
22. Biological properties of Ukrain in experimental and clinical investigation
23. The immunomodulating preparation Ukrain does not reduce anaphylactic sensitization in mice and guinea pigs
24. Inhibitory effect of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain) on ovalbumin antigenicity and antiovalbumin IgE antibody response in mice
25. Teratological evaluation of Ukrain in hamsters and rats
26. Estimation of direct influence of Ukrain preparation on influenza viruses and the bacteria E. coli and S. aureus
27. Interaction between Ukrain and aminophenazone in analgesic test in rodents
28. Modification of antinociceptive action of morphine by Ukrain in rodents
29. Antinoceptive effect of ten day administration of Ukrain in mice and interaction of the treatment with morphine
30. Interaction between Ukrain and morphine in their ten-day treatment in mice in the writhing syndrome test
31. Effect of six month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats
32. Effect of six-month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats. Part I: Preliminary studies of bone parameters
33. Effect of six-month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats. Part II. Preliminary studies of peripheral blood parameters
34. Effect of six-month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats. Part III: Preliminary studies of some hormone levels
35. Some biophysical properties of Ukrain
36. Certain biophysical properties of Ukrain
37. Ukrain and natural killer cells
38. Macroscopic UV-marking through affinity
39. Preliminary report on clinical experience in the use of Ukrain
40. Selective inhibition of in vitro cell growth by the antitumour drug Ukrain
41. Preliminary report on Ukrain studies of toxicity and immunomodulation (The effect on cytotoxicity)
42. Inhibition of tumor progression and metastases by the immunomodulating agent Ukrain
43. Sensitisation for specific lysis in target-effector-system with derivatives of Chelidonium majus alkaloids-Ukrain
44. Biological and physiological effects of Ukrain
45. In vitro effects of Chelidonium majus L. Alkaloid thiophosphoric acid conjugates (Ukrain) on the phenotype of normal human lymphocytes
46. Theoretical grounds and experimental confirmation of the antiviral effect of the preparation Ukrain
47. Influence of Ukrain on DNA, RNA and protein synthesis in malignant cells
48. Studies concerning the effect of Ukrain in vivo and in vitro
49. Comparative study of the cytostatic effects of oliphen and Ukrain
50. Influence of Ukrain on the redox processes of hepatocytes
51. Selective induction of programmed cell death (apoptosis) in malignant cells by the alkaloid derivative Ukrain (NSC-613570)
52. Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-651570)
53. Influence of Ukrain on human xenografts in vitro
54. Influence of Ukrain on immunological blood parameters in vitro and in vivo
55. Activation of spleen cell lytic activity by the alkaloid thiophophoric acid derivative: Ukrain
56. Modulation of immune effector cell cytolytic activity and turnout growth inhibition in vivo by Ukrain (NSC-651570)
57. In vitro effect of thiophosphoric acid derivatives from Chelidonium majus L. on normal lymphocyte subpopulation
58. Enhancement of macrophage tumouricidal activity by the alkaloid derivative Ukrain. In vitro and in vivo studies
59. Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators
60. Kinetics of responses to tumor antigens and mouse mammary tumor virus in BALB/c Grgl. mice
61. Modulation of the immune system by mammary tumor-derived factors
62. Immunological and tumoricidal properties of Ukrain
63. Evaluation of biological response modifiers in the enhancement of tumor uptake of technetium-99m labeled macromolecules
64. Status of the NCI preclinical antitumor drug discovery screen
65. The malignotoxic and immune modulating property of the alkaloid derivative Ukrain
66. Cytostatic and cytotoxic effects of Ukrain on malignant cells
67. Synergic influence of Ukrain and protoporphyrine amino conjugates on human malignant cell lines
68. Synergic influence of Ukrain and protoporphyrin amino acids conjugates on human malignant cell lines
69. Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. ("Ukrain") as an immunostimulant in patients with various carcinomas
70. Preliminary studies on the effect of Ukrain on the immunological response in patients with malignant tumours
71. Ukrain both as an anticancer and immunoregulatory agent
72. The effects of thiophosphoric acid (Ukrain) on cervical cancer, stage IB bulky
73. Attempts of immunotherapy of malignances by the use of chelidonium majus L. - Plant immunostimulator
74. Regression of malignant tumors using the immunostimulating experimental drug Ukrain
75. Immunological profile in patients with small cell lung cancer (SCLC) treated with alkaloid derivate from Chelidonium majus L.
76. Clinical studies of Ukrain in terminal cancer patients (phase II)
77. Lymphocyte subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain)
78. Results of phase II clinical studies with Ukrain
79. Ukrain monotheraphy for treatment of colorectal cancer
80. Effect of Ukrain preparation on immune response in mice affected by influenza virus
81. Ukrain - A novel effective drug for treatment of colonic and rectal cancer
82. Clinical studies of Ukrain in healthy volunteers (phase I)
83. Stimulation of phagocytic activity in vitro, in vivo and in the clinic by Ukrain
84. Some immunohematological effects of Ukrain
85. Influence of Ukrain on breast cancer
86. Effect of three months treatment with Ukrain on peripheral blood morphology in rodents
87. Effect of single and three months treatment with Ukrain on aminotransferases (ALT and AST) and on the serum protein level in rodents
88. Effect of single and prolonged administration of Ukrain on prolactin concentration in rats
89. Influence of Ukrain on breast carcinomas
90. Ukrain - Drug of the future in the cancer treatment?
91. Chelidonium majus L. (Ukrain) in the treatment of cancer patients
92. Action of Ukrain, a cytostatic and immunomodulating drug, on effects of irradiation
93. Influence of Ukrain on patients with surgically treated breast cancer
94. Influence of Ukrain on patients with surgically treated breast cancer Part I. Clinical and laboratory parameters
95. Influence of Ukrain on patients with surgically treated breast cancer Part II. Hormonal profile
96. Influence of Ukrain on patients with surgically treated breast cancer Part III. The immune system
97. Influence of Ukrain on patients with surgically treated breast cancer. Part IV. Electromicroscopic and cytochemical evaluation
98. Amino acids and their derivatives in blood plasma of patients with breast cancer treated with Ukrain. Part V
99. Amino acids and their derivatives in tumour tissue from patients with breast cancer treated with Ukrain. Part VI
100. Electron microscopy and morpho-histochemical analysis of effect of Ukrain on the breast cancer tissue
101. Free amino acids and their derivatives in blood plasma and tumor tissue in patients with breast cancer and the background of treatment with a new anticancer preparation Ukrain
102. Ukrain with chemotherapy in malignant melanoma
103. Ukrain monotherapy in malignant melanoma
104. Ukrain treatment of rhabdomyosarcoma
105. Ukrain therapy of recurrent breast cancer with lung metastases
106. Biophysical effects of Ukrain therapy in patient with breast cancer
107. Ukrain treatment in carcinoma of the cervix
108. Combined therapy with Ukrain and chemotherapy in ovarian cancer
109. Ukrain treatment in a patient with non-seminomatous germ-cell tumour of testis
110. Ukrain treatment in carcinoma of the oesophagus
111. Ukrain treatment in a frontal anaplastic grade III astrocytoma
112. Ukrain therapy of a recurrent astrocytoma of the optic nerve
113. Potential therapeutic efficacy of Ukrain (NSC 631570) in patients with AIDS with Kaposi's sarcoma
114. Does the Ukrain preparation protect mice against lethal doses of bacteria?
115. Testing Ukrain as an anti-influenza remedy
116. Theoretical grounds and experimental confirmation of antiviral effect of the preparation Ukrain
117. Biological activity of some thiophosphamide derivatives of alkaloids with respect to influenza virus