Modulation of early response gene expression by prostaglandins in cultured rat retinal pigment epithelium cells

Current Eye Research

Volumn 21, Issue 6, 2000, Pages 968-974

  Ershov, Alexey V ^a   Parkins, Nilda ^a   Lukiw, Walter J ^a   Bazan, Nicolas G ^a,b  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LSU Neuroscience Center   (United States)

Author keywords

Cell culture; Gene expression; Phagocytosis; Prostaglandins; Retinal pigment epithelium; Rod outer segments

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; MESSENGER RNA; PROSTAGLANDIN; PROSTAGLANDIN D2; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN J2; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; NORTHERN BLOTTING; PHAGOCYTOSIS; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA ROD OUTER SEGMENT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, NORTHERN; CELLS, CULTURED; DNA; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; EYE PROTEINS; GENE EXPRESSION; IMMEDIATE-EARLY PROTEINS; IMMUNOENZYME TECHNIQUES; PHAGOCYTOSIS; PIGMENT EPITHELIUM OF EYE; PROSTAGLANDINS; RATS; RATS, LONG-EVANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; ROD OUTER SEGMENTS; TRANSCRIPTION FACTORS;

EID: 0034444643     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.21.6.968.6987     Document Type: Article

References (15)

1. Bok D. Retinal photoreceptor-pigment epithelium interactions. Invest Ophthalmol Vis Sci. 1985;26:1659-94.
2. Bok D, Hall MO. The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J Cell Biol. 1971;49:664-682.
3. Chaitin MH, Hall MO. Defective ingestion of rod outer segments by cultured dystrophic rat pigment epithelial cells. Invest Ophthalmol Vis Sci. 1983;24:812-820.
4. Gordon WC, Bazan NG. Retina. In: Harding JJ, ed. Biochemistry of the Eye. London; Chapman and Hall; 1997:144-275.
5. Ershov AV, Lukiw WJ, Bazan NG. Selective transcription factor induction in retinal pigment epithelial cells during photoreceptor phagocytosis. J Biol Chem. 1996;271:8458-28462.
6. Bazan NG, Allan G. Signal transduction and gene expression in the eye: A contemporary view of the proinflammatory, anti-inflammatory and modulatory roles of prostaglandins and other bioactive lipids. Survey of Ophthalmology. 1997;41(Suppl. 2),S23-S34.
7. Hall MO, Burgess BL, Abrams TA, Ershov AV, Gregory CY. Further studies on the identification of the phagocytosis receptor of rat retinal pigment epithelial cells. Exp Eye Res. 1996;63:255-264.
8. Ershov AV, Bazan NG. Photoreceptor phagocytosis selectively activates PPAR gamma expression in retinal pigment epithelial cells. J Neurosci Res. 2000;60:328-337.
9. Birkle DL, Bazan NG. Light exposure stimulates arachidonic acid metabolism in intact rat retina and isolated rod outer segments. Neurochemical Research 1989;14: 185-190.
10. Beuckmann CT, Gordon WC, Kanaoka Y, Eguchi N, Marcheselli VL, Gerashchenko DY, Urade Y, Hayaishi O, Bazan NG. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. J Neurosci. 1996;16:6119-6124.
11. Ershov AV, Bazan NG. Induction of cyclooxygenase-2 gene expression in retinal pigment epithelium cells by photoreceptor rod outer segment phagocytosis and growth factors. J Neurosci Res. 1999;58:254-261.
12. Bar-Ilan A, Savion N, Naveh N. Alpha melanocyte stimulating hormone (alpha-MSH) enhances eicosanoid production by bovine retinal pigment epithelium. Prostaglandins. 1992;43:31-44.
13. Hanna N, Pen KG, Abran D, Hardy P, Doke A, Lachapelle P, Roy MS, Orquin J, Varma DR, Chemtob S. Light induces peroxidation in retina by activating prostaglandin G/H synthase. Free Radical Biology & Medicine. 1997;23:885-897.
14. Gregory CY, Abrams TA, Hall MO. cAMP production via the adenylyl cyclase pathway is reduced in RCS rat RPE. Invest Ophthalmol Vis Sci. 1992;33:3121-3124.
15. Hall MO, Abrams TA, Mittag TW. The phagocytosis of rod outer segments is inhibited by drugs linked to cyclic adenosine monophosphate production. Invest Ophthalmol Vis Sci. 1993;34:2392-2401.