Discovery of the first non-peptide antagonist of the motilin receptor

Drug Design and Discovery

Volumn 17, Issue 3, 2000, Pages 243-251

  Beavers, Mary Pat ^a   Gunnet, Joseph W ^a   Hageman, William ^a   Miller, William ^a   Moore, John B ^a   Zhou, Lubing ^a   Chen, Robert H K ^b   Xiang, Amy ^a   Urbanski, Maud ^a   Combs, Donald W ^c   Mayo, Kevin H ^d   Demarest, Keith T ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b ChemPacific Corporation   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d University of Minnesota   (United States)

Author keywords

3D pharmacophore; Electronic database searching; Gastrointestinal; Hydrophobic staple motif; Motilin; N capping box motif; Peptide folding

Indexed keywords

CYCLOPENTENE DERIVATIVE; HORMONE ANTAGONIST; HORMONE RECEPTOR; IODINE 125; MOTILIN; MOTILIN RECEPTOR; RWJ 64583; RWJ 67849; RWJ 68022; RWJ 68023; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; ASSAY; CALCIUM MOBILIZATION; CELL LINE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DATA BASE; DISEASE ASSOCIATION; DRUG ACTIVITY; DRUG BINDING; DRUG CLASSIFICATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ELECTRONICS; EVALUATION; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MOTILITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFORMATION PROCESSING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE ANALYSIS; PHARMACOPHORE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STRUCTURE; RABBIT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER MEMBRANE; STOMACH ANTRUM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; DUODENUM; GASTROINTESTINAL MOTILITY; HUMANS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MOTILIN; RABBITS; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE;

EID: 0034435570     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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