A liquid-phase process suitable for large-scale synthesis of phosphorothioate oligonucleotides

Organic Process Research and Development

Volumn 4, Issue 3, 2000, Pages 225-231

  Bonora, G M ^a   Rossin, R ^b   Zaramella, S ^c   Cole, D L ^d   Eleuteri, A ^d   Ravikumar, V T ^d  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c KAROLINSKA INSTITUTE   (Sweden)

^d ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034381823     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op990096l     Document Type: Article

References (14)

1. Rawls, R. L. Chem. Eng. News 1997, 35-39.
2. (a)Andrade, M.; Scozzari, A. N.; Cole, D. L.; Ravikumar, V. T. Bioorg. Med. Chem. Lett. 1994, 4, 2017-2022.
3. (b) Seliger, H. In Methods in Molecular Biology; Agrawal, S., Ed.; Vol. 20, Protocols for Oligonucleotides and Analogues; Humana Press Inc.: Totowa, New Jersey, 1993; pp 391-435.
4. (a)Padmapriya, A. A.; Tang, J.-Y.; Agrawal, S. Antisense Res. Dev. 1994, 4, 185-199.
5. (b) Ravikumar, V. T.; Andrade, M.; Wyrzykiewicz, T. K.; Scozzari, A. N.; Cole, D. L. Nucleosides Nucleotides 1995,14, 1219-1226.
6. (c) Tsou, D.; Hampel, A.; Andrus, A.; Vinayak, P. Nucleosides Nucleotides 1995, 14, 1481-1492.
7. Bayer, E.; Mutter, M. Nature 1972, 237, 513-514.
8. Bonora, G. M. Appl. Biocnem. Biotechnol. 1995, 54, 3-17.
9. Scremin, C. L.; Bonora, G. M. Tetrahedron Lett. 1993, 34, 4663-4666.
10. Cohen, J. S. in Antisense Res. Appl. Crooke S. T., Lebleu, B., Eds., CRC Press: Boca Raton, 1993; pp 205-222.
11. Krotz, A. H.; Klopchin, P.; Cole, D. L.; Ravikumar, V. T. Bioorg. Med. Chem. Lett. 1997, 7, 73-78.
12. Eleuteri, A.; Cheruvallath, Z. S.; Capaldi, D. C.; Cole, D. L.; Ravikumar, V. T. Nucleosides Nucleotides 1999, 18, 1803-1807.
13. Bonora, G. M.; Biancotto, G.; Maffini, M.; Scremin, C. L. Nucleic Acids Res. 1993, 21, 1213-1217.
14. Sinha, N. D. In Antisense. From Technology to Therapy; Schliengensiepen, R., Brysch, W., Schliengensiepen, K.-H., Eds.; Blackwell Sciences Ltd: Berlin, Germany, 1997; pp 29-58.