Whole-body protein metabolism and plasma profiles of amino acids and hormones in growing barrows fed diets adequate or deficient in lysine

Canadian Journal of Animal Science

Volumn 80, Issue 4, 2000, Pages 585-595

  Roy, N ^a,c   Lapierre, H ^b   Bernier, J F ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b AGRICULTURE AND AGRI FOOD CANADA   (Canada)

^c AGRESEARCH GRASSLANDS   (New Zealand)

Author keywords

Hormone; Leucine; Lysine; Metabolism; Pigs; Protein

Indexed keywords

EID: 0034360726     PISSN: 00083984     EISSN: None     Source Type: Journal    
DOI: 10.4141/A98-057     Document Type: Article

References (55)

1. Abribat, T., Brazeau, P., Davignon, I. and Garrel, D. R. 1993. Insulin-like growth factor 1 blood levels in severely burned patients: effects of time post injury, age of patient and severity of burn. Clin. Endocrinol. 39: 1-7.
2. Airhart, J., Vidrich, A. and Khairallah, E. A. 1974. Compartmentation of free amino acids for protein synthesis in rat liver. Biochem. J. 149: 539-548.
3. Allison, J. B. 1964. The nutritive value of dietary proteins. Pages 41-86 in H. N. Munro and J. B. Allison, eds. Mammalian protein metabolism. Volume II. Academic Press, New York, NY.
4. Association of Offical Analytical Chemists 1984. Official Methods of Analysis. 15th ed. AOAC, Washington, DC.
5. Asplund, J. M. 1994. The significance and interpretation of balance methods of determining the utilization of dietary proteins. Ch. 3. Pages 29-42. in J. M. Asplund, ed. Principles of protein nutrition of ruminants. CRC Press Inc., Boca Raton, FL.
6. Brookes, I. M., Owens, F. N. and Garrigus, U. S. 1972. Influence of amino acid level in the diet upon amino acid oxidation by the rat. J. Nutr. 102: 27-36.
7. Brouwer, E. 1965. Report of sub-committee on constants and factors. Pages 441-443 in K. L. Blaxter, ed. Energy metabolism. EAAP 77, Academic Press, London, U.K.
8. Buonomo, F. C. and Baile, C. A. 1990. The neurophysiological regulation of growth hormone secretion. Domest. Anim. Endocrinol. 7: 435-450.
9. Calder, A. G. and Smith, A. 1988. Stable isotope ratio analysis of leucine and ketoisocaproic acid in blood plasma by gas chromatography/mass spectrometry. Use of the tertiary butyldimethylsilyl derivatives. Rapid Commun. Mass Spectrom. 2: 14-16.
10. Campbell, I. M. 1974. Incorporation and dilution values - their calculation in mass spectrally assayed stable isotope labeling experiments. Bioorg. Chem. 3: 386-397.
11. Canadian Council on Animal Care. 1993. Guide to the care and use of experimental animals. E. D. Olfert, B. M. Cross and A. A. McWilliam, eds. 2nd Edition. Guide Vol. 1. CCAC, Ottawa, ON.
12. Canfield, L. M. and Chytil, F. 1978. Effect of low lysine diet on rat liver nuclear metabolism. J. Nutr. 108: 1336-1342.
13. Chinkes, D., Klein, S., Zhang, X.-J and Wolfe, R. 1996. Infusion of labeled KIC is more accurate than labeled leucine to determine human muscle protein synthesis. Am. J. Physiol. 270: E67-E71.
14. Edmonds, M. S. and Baker, D. H. 1987. Amino acid excesses for young pigs: effects of excess methionine, tryptophan, threonine or leucine. J. Anim. Sci. 64: 1664-1671.
15. Everson, W. V., Flaim, K. E., Susco, D. M., Kimball, S. R. and Jefferson, L. S. 1989. Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes. Am. J. Physiol. 256: C18-C27.
16. Floyd, J. C., Fajans, S. S., Conn, J. W., Knopf, R. F. and Rull, J. 1966. Stimulation of insulin secretion by amino acids. J. Clin. Invest. 45: 1487-1502.
17. Fuller, M. F., Reeds, P. J., Cadenhead, A. and Sève B. 1987a. Effects of the amount and quality of dietary protein on nitrogen metabolism and protein turnover of pigs. Br. J. Nutr. 58: 287-300.
18. Fuller, M. F., Cadenhead, A., Mollison, G. and Sève B. 1987b. Effects of the amount and quality of dietary protein on nitrogen metabolism and heat production in growing pigs. Br. J. Nutr. 58: 277-285.
19. Gill, J. L. 1978. Design and analysis of experiments in the animal and medical sciences. Iowa State University Press, Ames, IA. 409 pp.
20. 3) in rats. Clin. Res. 26: 283A.
21. Harper, A. E. 1986. Enzymatic basis for adaptive changes in amino acid metabolism. Pages 409-414 in T. G. Taylor and N. K. Jenkins, eds. Proceedings of the XIII International Congress of Nutrition. John Libbey, London, U.K.
22. Jepson, M. M., Bates, P. C. and Millward, D. J. 1988. The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein in the rat. Br. J. Nutr. 59: 397-415.
23. Lapierre, H., Farmer, C., Girard, C. and Brazeau, P. 1992. Effect of age and intake on growth hormone kinetics in dairy heifers. Domest. Anim. Endocrinol. 9: 199-207.
24. Lapierre, H., Bernier, J. F., Dubreuil, P., Reynolds, C. K., Farmer, C., Ouellet, D. R. and Lobley, G. E. 1999. The effect of intake on protein metabolism across splanchnic tissues in growing beef steers. Br. J. Nutr. 81: 457-466.
25. Lapierre, H., Farmer, C., Reynolds, C.K., Bernier, J.F., Lobley, G. E. and Dubreuil, P. 2000. The effect of intake level on whole body kinetics and hepatic removal of somatotropin in growing beef steers. Dom. Anim. Endocrinol. 18: 217-227.
26. Lobley, G. E., Connell, A., Lomax, M. A., Brown, D. S., Milne, E., Calder, A. G. and Farningham, D. A. H. 1995. Hepatic detoxification of ammonia in the ovine liver: possible consequences for amino acid catabolism. Br. J. Nutr. 73: 665-685.
27. Lobley, G. E. 1998. Nutritional and hormonal control of peripheral tissue metabolism in farm species. Livest. Prod. Sci. 56: 91-114.
28. Morrison, A. B., Middleton, E. J. and McLaughlan, J. M. 1961. Blood amino acid studies. II. Effects of dietary lysine concentration, sex, and growth rate on plasma free lysine and threonine levels in the rat. Can. J. Biochem. Physiol. 39: 1675-1680.
29. Muramatsu, T. 1990. Nutrition and whole-body protein turnover in the chicken in relation to mammalian species. Nutr. Res. Rev. 3: 211-228.
30. National Research Council. 1988. Nutrient requirements of swine. 9th revised edition. National Academy Press, Washington, DC. 93 pp.
31. National Research Council. 1998. Nutrient requirements of swine. 10th revised edition. National Academy Press, Washington, DC. 189 pp.
32. Noblet, J., Henry, Y. and Dubois S. 1987. Effect of protein and lysine levels in the diet on body gain composition and energy utilization in growing pigs. J. Anim. Sci. 65: 717-726.
33. Phillips, L. S. 1986. Nutrition, somatomedins, and the brain. Metabolism 35: 78-87.
34. Quinn Baumann, P., Stirewalt, W. S., O'Rourke, B. D., Howard, D. and Sreekumaran N. 1994. Precursor pools of protein synthesis: a stable isotope study in a swine model. Am. J. Physiol. 267: E203-E209.
35. Reeds, P. J. 1987. Metabolic control and future opportunities for growth regulation. Anim. Prod. 45: 149-169.
36. Rérat, A., Simoes-Nuñes, C., Mendy, F., Vaissade, P. and Vaugelade, P. 1992. Splanchnic fluxes of amino acids after duodenal infusion of carbohydrate solutions containing free amino acids or oligopeptides in the non-anaesthetized pig. Br. J. Nutr. 68: 111-138.
37. Roy, N. 1997. Métabolisme protéique chez des porcs en croissance alimentés avec des régimes adéquats ou carencés en lysine. Ph.D. Dissertation. Université Laval, Ste-Foy, QC.
38. Roy, N., Lapierre, H. and Bernier, J. F. 1998. Whole-body protein synthesis in growing barrows: diurnal and day-to-day variation and the effect of the site of tracer infusion and sampling. Can. J. Anim. Sci. 78: 575-585.
39. Roy, N. C., Lapierre, H., Yen, J. T. and Bernier, J. F. 2000. Net fluxes of amino acids across the portal-drained viscera and the liver of pigs fed a diet adequate or deficient in lysine. Proceedings of the 9th AAAP and XXIII ASAP Conference, Sydney, Australia Vol A: 91-94.
40. Salter, D. N., Montgomery, A. I, Hudson, A., Quelch, D. B. and Elliott, R. J. 1990. Lysine requirements and whole-body protein turnover in growing pigs. Br. J. Nutr. 63: 503-513.
41. Schneible, P. A., Airhart, J. and Low, R. B. 1981. Differential compartmentation of leucine for oxidation and for protein synthesis in cultured skeletal muscle. J. Biol. Chem. 256: 4888-4894.
42. Sève, B. and Ballèvre, O. 1991. Approches métaboliques du besoin en acides aminés chez le porc en croissance. Journées Rech. Porcine en France 23: 91-110.
43. Simoes Nuñes, C., Galibois, L, Rérat, A., Savoie, L. and Vaugelade, P. 1991. Hepatic and portal-drained viscera balances of amino acids, insulin, glucagon and gastrin in the pig after ingestion of casein or rapeseed proteins. Reprod. Nutr. Dev. 31: 217-231.
44. 3 levels in protein-malnourished rats. Metabolism 31: 538-542.
45. SAS System Institute, Inc. 1989. SAS user's guide: Statistics. Version 5 Edition. SAS Institute Inc., Cary, NC.
46. Takahashi, S., Kajikawa, M., Umezama, T., Takahashi, S. I., Kato, H., Miura, Y., Nam, T. J., Noguchi, T. and Naito, H. 1990. Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin C concentration in the rat. Br. J. Nutr. 63: 521-534.
47. Thomas, G. B., Mercer, J. E., Karalis, T., Rao, A., Cummins, J. T. and Clarke, I. J. 1990. Effect of restricted feeding on the concentrations of growth hormone (GH), gonadotropins, and prolactin (PRL) in plasma, and on the amounts of messenger ribonucleic acid for GH, gonadotropin subunits, and PRL in the pituitary glands of adult ovariectomized ewes. Endocrinology 126: 1361-1367.
48. Waterlow, J. C., Garlick, P. J. and Millward, D. J. 1978. Protein turnover in mammalian tissues and in the whole body. North-Holland Publishing Company, New York, NY. 804 pp.
49. Watt, P. W., Corbett, M. E. and Rennie, M. J. 1992. Stimulation of protein synthesis in pig skeletal muscle by infusion of amino acids during constant insulin availability. Am. J. Physiol. 263: E453-E460.
50. Williams, H. H., Curtin, L. V., Abraham, J., Loosli, J. K. and Maynard, L. A. 1954. Estimation of growth requirements for amino acids by assay of the carcass. J. Biol. Chem. 205: 277-286.
51. Wolfe, R. R. 1992. Radioactive and stable isotope tracers in biomedicine: Principles and practice of kinetic analysis. Wiley-Liss, New York, NY. 471 pp.
52. Wray-Cahen, D., Nguyen, H. V., Burrin, D. G., Beckett, P. R., Fiorotto, M. L., Reeds, P. J., Wester, T. J. and Davis, T. A. 1998. Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development. Am. J. Physiol. 275: E602-E609.
53. Yang, C. J., Lee, D. W., Chung, I. B., Cho, Y. M., Shin, I. S., Chae, B. J., Kim, J. H. and Han, I. K. 1997. Developing model equation to subdivide lysine requirements into requirements for growth and maintenace in pigs. Asian-Australas. J. Anim. Sci. 19: 52-63.
54. Young, V. R. and Marchini, J. S. 1990. Mechanisms and nutritional significance of metabolic responses to altered intakes of protein and amino acids, with reference to nutritional adaptation in humans. Am. J. Clin. Nutr. 51: 270-289.
55. Zimmerman, R. A. and Scott, H. M. 1965. Interrelationship of plasma amino acid levels and weight gain in the chick as influenced by suboptimal and superoptimal dietary concentrations of single amino acids. J. Nutr. 87: 13-18.