Interpreting forensic DNA mixtures: Allowing for uncertainty in population substructure and dependence

Journal of the Royal Statistical Society. Series A: Statistics in Society

Volumn 163, Issue 2, 2000, Pages 241-254

  Fung, Wing K ^b   Hu, Yue Qing ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

DNA profile; Likelihood ratio; Match probability; Mixed samples; Population substructure

Indexed keywords

EID: 0034360572     PISSN: 09641998     EISSN: None     Source Type: Journal    
DOI: 10.1111/1467-985X.00168     Document Type: Article

References (26)

1. Aitken, C. G. G. and Stoney, D. A. (1991) The Use of Statistics in Forensic Science. New York: Horwood.
2. Balding, D. J. (1995) Estimating products in forensic identification using DNA profile. J. Am. Statist. Ass., 90, 839-844.
3. Balding, D. J. and Donnelly, P. (1995) Inference in forensic identification (with discussion). J. R. Statist. Soc. A, 158, 21-53.
4. Balding, D. J. and Nichols, R. A. (1994) DNA profile match probability calculation: how to allow for population stratification, relatedness, database selection and single bands. Forens. Sci. Int., 64, 125-140.
5. _ (1995) A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternity. Genetica, 96, 3-12.
6. Brenner, C. H. (1997) Proof of a mixed stain formula of Weir. J. Forens. Sci., 42, 221-222.
7. Dawid, A. P. and Mortera, J. (1996) Coherent analysis of forensic identification evidence. J. R. Statist. Soc. B, 58, 425-443.
8. Donnelly, P. (1995) Non-independence of matches at different loci in DNA profiles: quantifying the effect of close relatives on the match probability. Heredity, 75, 26-34.
9. Evett, I. W., Buffery, C., Wilcott, G. and Stoney, D. (1991) A guide to interpreting single locus profiles of DNA mixtures in forensic case. J. Forens. Sci. Soc., 31, 41-47.
10. Evett, I. W., Gill, P. D. and Lambert, J. A. (1998) Taking account of peak areas when interpreting mixed DNA profiles. J. Forens. Sci., 43, 62-69.
11. Foreman, L. A., Smith, A. F. M. and Evett, I. W. (1997) Bayesian analysis of DNA profiling data in forensic identification applications (with discussion). J. R. Statist. Soc. A, 160, 429-469.
12. Fung, W. K. (1996a) Are convenience DNA samples significantly different? Forens. Sci. Int., 82, 233-241.
13. _ (1996b) Tests on independence of VNTR alleles in the Chinese population in Hong Kong. In Modelling and Prediction (eds J. C. Lee, W. O. Johnson and A. Zellner), pp. 294-304. New York: Springer.
14. Geisser, S. and Johnson, W. (1992) Testing Hardy-Weinberg equilibrium on allelic data from VNTR loci. Am. J. Hum. Genet., 51, 1084-1088.
15. Hall, M. (1967) Combinatorial Theory. New York: Wiley.
16. Harbison, S. A. and Buckleton, J. S. (1998) Applications and extensions of subpopulation theory: a caseworkers guide. Sci. Just., 38, 249-254.
17. Hartmann, J. M., Houlihan, B. T., Keister, R. S. and Buse, E. L. (1997a) The effect of ethnic and racial population substructuring on the estimation of multi-locus fixed-bin VNTR RFLP genotype probabilities. J. Forens. Sci., 42, 232-240.
18. Hartmann, J. M., Houlihan, B. T., Thompson, L. D., Chan, C., Baldwin, R. A. and Buse, E. L. (1997b) The effect of sampling error and measurement error and its correlation on the estimation of multi-locus fixed-bin VNTR RFLP genotype probabilities. J. Forens. Sci., 42, 241-245.
19. Jeffreys, A. J., Wilson, V. and Thein, S. L. (1985) Individual-specific 'fingerprints' of human DNA. Nature, 316, 76-79.
20. Lindley, D. V. (1990) The present position of Bayesian statistics. Statist. Sci., 5, 44-89.
21. Morton, N. E. (1992) Genetic structure of forensic populations. Proc. Natn. Acad. Sci. USA, 89, 2556-2560.
22. National Research Council (1996) The Evaluation of Forensic DNA Evidence. Washington DC: National Academy Press.
23. Roeder, K. (1994) DNA fingerprinting: a review of the controversy (with discussion). Statist. Sci., 9, 222-278.
24. Weir, B. S. (1992) Independence of VNTR alleles defined as fixed bins. Genetics, 130, 873-887.
25. Weir, B. S., Triggs, C. M., Starling, L., Stowell, L. I., Walsh, K. A. J. and Buckleton, J. (1997) Interpreting DNA mixtures. J. Forens. Sci., 42, 213-222.
26. Wright, S. (1951) The genetical structure of populations. Ann. Eugen., 15, 159-171.