Mechanisms of mitochondrial protein import

Essays in Biochemistry

Volumn 36, Issue , 2000, Pages 61-73

  Gordon, Donna M ^a   Dancis, Andrew ^a   Pain, Debkumar ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; MITOCHONDRIAL PROTEIN; PEPTIDYLTRANSFERASE;

ANIMAL; CYTOSOL; HUMAN; METABOLISM; MITOCHONDRION; PHYSIOLOGY; PROTEIN FOLDING; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CYTOSOL; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR CHAPERONES; PEPTIDYL TRANSFERASES; PROTEIN FOLDING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 0034351420     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/bse0360061     Document Type: Article

References (25)

1. Neupert, W. (1997) Protein import into mitochondria. Annu. Rev. Biochem. 66, 863-917
2. Voos, W., Martin, H., Krimmer, T. & Pfanner, N. (1999) Mechanisms of protein translocation into mitochondria. Biochim. Biophys. Acta 1422, 235-254
3. Tokatlidis, K. & Schatz, G. (1999) Biogenesis of mitochondrial inner membrane proteins. J. Biol. Chem. 274, 35285-35288
4. Söllner, T., Griffiths, G., Pfaller, R., Pfanner, N. & Neupert, W. (1989) MOM19, an import receptor for mitochondrial precursor proteins. Cell 59, 1061-1070
5. Kiebler, M., Keil, P., Schneider, H., van der Klei, I.J., Pfanner, N. & Neupert, W. (1993) The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell 74, 483-492
6. Gratzer, S., Lithgow, T., Bauer, R.E., Lamping, E., Paltauf, F., Kohlwein, S.D., Haucke, V., Junne, T., Schatz, G. & Horst, M. (1995) Mas37p, a novel receptor subunit for protein import into mitochondria. J. Cell Biol. 129, 25-34
7. Söllner, T., Pfaller, R., Griffiths, G., Pfanner, N. & Neupert, W. (1990) A mitochondrial import receptor for the ATP/ADP carrier. Cell 62, 107-115
8. Dietmeier, D., Hönlinger, A., Bömer, U., Dekker, P.J.T., Eckerskorn, C., Lottspeich, F., Kübrich, M. & Pfanner, N. (1997) Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature (London) 388, 195-200
9. Kassenbrock, C.K., Cao, W. & Douglas, M.G. (1993) Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. EMBO J. 12, 3023-3034
10. Hönlinger, A., Bömer, U., Alconada, A., Eckerskorn, C., Lottspeich, F., Dietmeier, K. & Pfanner, N. (1996) Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. EMBO J. 15, 2125-2137
11. Vestweber, D., Brunner, J., Baker, A. & Schatz, G. (1989) A 42K outer membrane protein is a component of the yeast mitochondrial import site. Nature (London) 341, 205-209
12. Kiebler, M., Pfaller, R., Söllner, T., Griffiths, G., Horstmann, H., Pfanner, N. & Neupert, W. (1990) Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature (London) 348, 610-616
13. Hill, K., Model, K., Ryan, M.T., Dietmeier, K., Martin, F., Wagner, R. & Pfanner, N. (1998) Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins. Nature (London) 395, 516-521
14. Künkele, K.-P., Heins, S., Dembowski, M., Nargang, F.E., Benz, R., Thieffry, M., Walz, J., Lill, R., Nussberger, S. & Neupert, W. (1998) The preprotein translocation channel of the outer membrane of mitochondria. Cell 93, 1009-1019
15. Schatz, G. (1997) Just follow the acid chain. Nature (London) 388, 121-122
16. Maarse, A.C., Blom, J., Keil, P., Pfanner, N. & Meijer, M. (1994) Identification of the essential yeast protein MIM17, an integral mitochondrial inner membrane protein involved in protein import. FEBS Lett. 349, 215-221
17. Ryan, K.R., Menold, M.M., Garrett, S. & Jensen, R.E. (1994) SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Mol. Biol. Cell 5, 529-538
18. Dekker, P.J., Keil, P., Rassow, J., Maarse, A.C., Pfanner, N. & Meijer, M. (1993) Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett. 330, 66-70
19. Emtage, J.L.T. & Jensen, R.E. (1993) MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J. Cell Biol. 122, 1003-1012
20. Maarse, A.C., Blom, J., Grivell, L.A. & Meijer, M. (1992) MP11, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. EMBO J. 11, 3619-3628
21. Scherer, P.E., Manning-Krieg, U.C., Jenö, P., Schatz, G. & Horst, M. (1992) Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane. Proc. Natl. Acad. Sci. USA 89, 11930-11934
22. Sepuri, N.B.V., Gordon, D.M. & Pain, D. (1998) A GTP-dependent "push" is generally required for efficient protein translocation across the mitochondrial inner membrane into the matrix. J. Biol. Chem. 273, 20941-20950
23. Schneider, H.-C., Berthold, J., Bauer, M.F., Dietmeier, K., Guiard, B., Brunner, M. & Neupert, W. (1994) Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature (London) 371, 768-774
24. Click, B.S. (1995) Can Hsp70 proteins act as force-generating motors? Cell 80, 11-14
25. Wallace, D.C. (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases. Science 256, 628-632