Kinase-inducible domain-like region of HTLV type 1 Tax is important for NF-κB activation

AIDS Research and Human Retroviruses

Volumn 16, Issue 16, 2000, Pages 1607-1612

  Kuo, Y L ^a   Tang, Y ^a   Harrod, R ^a   Cai, P ^a   Giam, C Z ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; TAX PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; GENE DELETION; HUMAN T CELL LEUKEMIA VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TRANSACTIVATION;

AMINO ACID MOTIFS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; ENZYME ACTIVATION; GENE PRODUCTS, TAX; HELA CELLS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LUCIFERASES; NF-KAPPA B; PHOSPHOTRANSFERASES; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 0034331169     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220050193038     Document Type: Article

References (40)

1. An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300
2. Human T-cell lymphotropic virus type I (HTLV-1) transcriptional activator, Tax, enhances CREB binding to HTLV-1 21-base-pair repeats by protein-protein interaction
3. Interaction of the human T-cell lymphotropic virus type I (HTLV-1) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-1 enhancer
4. The trans-activator Tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1
5. Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB
6. Quantitative studies of the effect of HTLV-1 Tax protein on CREB protein-DNA binding
7. Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I Tax and CREB
8. Chimeric proteins composed of Jun and CREB define domains required for interaction with the human T-cell leukemia virus type 1 Tax protein
9. The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein
10. Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax
11. Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax
12. Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats
13. Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factors
14. The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae
15. Human T-cell leukemia virus type I Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter
16. In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax
17. The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove
18. Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking
19. An extended alpha-helix and specific amino acid residues opposite the DNA-binding surface of the cAMP response element binding protein basic domain are important for human T cell lymphotropic retrovirus type I Tax binding
20. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
21. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation
22. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300
23. PCAF interacts with Tax and stimulates Tax transactivation in a histone acetyltransferase-independent manner
24. p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex
25. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4
26. Human T-cell leukemia virus type 1 Tax and cell cycle progression: Role of cyclin D-cdk and p11ORb
27. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
28. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein
29. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
30. IKKgamma mediates the interaction of cellular IkappaB kinases with the Tax transforming protein of human T cell leukemia virus type 1
31. Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma
32. Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene
33. Evidence in support of a role for human T-cell leukemia virus type I Tax in activating NF-kappa B via stimulation of signaling pathways
34. Inactivation of IkappaBbeta by the Tax protein of human T-cell leukemia vires type 1: A potential mechanism for constitutive induction of NF-kappaB
35. Persistent activation of NF-kappa B/Rel by human T-cell leukemia vires type 1 Tax involves degradation of I kappa B beta
36. The Tax oncoprotein of human T-cell leukemia vires type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta
37. HTLV-1 Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation
38. Cytoplasmic forms of human T-cell leukemia vires type 1 Tax induce NF-kappaB activation
39. A positive genetic selection for disrupting protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP
40. Identification of HTLV-1 Tax transactivator mutants exhibiting novel transcriptional phenotypes