Defining the requirements for peptide recognition in gene therapy-induced T cell tolerance

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 4842-4847

  Bagley, J ^a   Wu, Y ^a   Sachs, D H ^a   Iacomini, J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; FEMALE; GENE THERAPY; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TRANSPLANTATION; T LYMPHOCYTE;

EID: 0034326633     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.4842     Document Type: Article

References (25)

1. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
2. Gene therapy in organ transplantation
3. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene
4. Specific unresponsiveness to a retrovirally transferred class I antigen is controlled through the helper pathway
5. The mechanism of specific prolongation of class I mismatched skin grafts induced by retroviral gene therapy
6. Cellular basis of skin allograft rejection: An in vivo model of immune-mediated tissue destruction
7. Antigen processing and presentation in transplantation
8. + T cells are able to reject class I disparate allografts
9. Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice
10. Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies
11. Flow cytometry as an analytical and preparative tool in immunology
12. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex beating Lyt2 antigen block T cell-mediated cytolysis in the absence of complement
13. Characterization of the murine T cell surface molecule designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu 3/T4 molecule
14. Characterization of mixed allogeneic chimeras: Immunocompetence, in vitro reactivity, and genetic specificity of tolerance
15. Effect of internal viral sequences on the utility of retroviral vectors
16. Long-term expression of the gene encoding green fluorescent protein in murine hematopoietic cells using retroviral gene transfer
17. Construction and use of a safe and efficient amphotropic packaging cell line
18. Antigen processing and presentation
19. Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells
20. Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles
21. Capture and processing of exogenous antigens for presentation on MHC molecules
22. Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen
23. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross react in the cytotoxic assay
24. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
25. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction