Active GPIIb-IIIa conformations that link ligand interaction with cytoskeletal reorganization

Blood

Volumn 96, Issue 7, 2000, Pages 2487-2495

  Mondoro, T H ^a   McCabe White, M ^a   Jennings, L K ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CELL ADHESION MOLECULE; FIBRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IIIA ANTIBODY; PROTEIN ANTIBODY; TALIN; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ARTICLE; BLOOD CLOT RETRACTION; CYTOSKELETON; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE STRUCTURE;

EID: 0034307677     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.7.2487     Document Type: Article

References (40)

1. Specific roles for platelet surface glycoproteins in platelet function
2. Platelets and their membranes in hemostasis: Physiology and pathology
3. Molecular defects in interactions of platelets with the vessel wall
4. Platelet membrane glycoproteins: Functions in cellular interactions
5. Platelet contractile regulation in an isometric system
6. Ultrastructure of clots during isometric contraction
7. Platelets and fibrin strands during clot retraction
8. Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex
9. Integrins: A family of cell receptors
10. Exposure of platelet fibrinogen receptors by ADP and epinephrine
11. Human platelets possess an inducible and saturable receptor specific for fibrinogen
12. Fibrinogen receptor exposure and aggregation of human blood platelets produced by ADP and chilling
13. 3 integrin reconstituted into planar lipid bilayers
14. A conformation-dependent epitope of human platelet glycoprotein IIIa
15. 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function
16. Platelet collagen adhesion: Inhibition by a monoclonal antibody that binds glycoprotein IIb
17. Interspecies comparison of platelet aggregation, LIBS expression and clot retraction: Observed differences in GPIIb-IIIa functional activity
18. Activation-independent exposure of the GPIIb-IIIa fibrinogen receptor
19. Selective induction of a glycoprotein IIIa ligand-induced binding site by fibrinogen and von Willebrand factor
20. Effect of trypsin on the exposed polypeptides and glycoproteins in the human platelet membrane
21. Solution stability of bovine fibrinogen
22. Assessment of lumiaggregometry for research and clinical laboratories
23. The effect of glycoprotein IIb-IIIa receptor occupancy on the cytoskeleton of resting and activated platelets
24. Cleavage of structural proteins during assembly of the head of the bacteriophage T4
25. Western blotting: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiograpic detection with antibody and radioiodinated protein A
26. Preaggregation reactions of platelets
27. Orientation and specificity of fibrin protofibril binding to ADP-stimulated platelets
28. The effect of peptides and monoclonal antibodies that bind to platelet glycoprotein IIb-IIIa complex on the development of clot tension
29. 3 complex that retains partial function in a novel form of type II Glanzmann's thrombasthenia
30. Secretable storage pools in platelets
31. Analysis of GP IIb/IIIa receptor number by quantification of 7E3 binding to human platelets
32. A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet GPIIb-IIIa complex
33. 3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation
34. 3 and its ligand and induces selective movements of ligand-occupied integrin
35. Changes in the composition of the platelet cytoskeleton in response to ADP: Effects of MK-852 and ARL 66096
36. The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction
37. Outside-in integrin signal transduction alpha IIb beta 3 tyrosine phosphorylation induced by platelet aggregation
38. 3 cytoplasmic domain mediates integrin-cytoskeletal interactions
39. 3 (GPIIb-IIIa) to talin
40. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation