Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients

Cancer Research

Volumn 60, Issue 19, 2000, Pages 5470-5478

  Westerhof, G R ^a   Ploemacher, R E ^a   Boudewijn, A ^a   Blokland, I ^a   Dillingh, J H ^a   McGown, A T ^a   Hadfield, J A ^a   Dawson, M J ^a   Down, J D ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

(2 HYDROXYETHYL)CYCLOHEXANE DIMETHANESULFONATE; BUSULFAN; GLUCOSE 6 PHOSPHATE ISOMERASE; HEPSULFAM; METHYLENE DIMESYLATE; PL 63; TREOSULFAN; UNCLASSIFIED DRUG;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL SUBPOPULATION; CHIMERA; CIS ISOMER; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG TOLERABILITY; HEMATOPOIETIC STEM CELL; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANIMAL; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BUSULFAN; COMPARATIVE STUDY; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELLS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING;

EID: 0034307331     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Recipient preparation for bone marrow transplantation. 1. Efficacy of total-body irradiation and busulfan
2. Relationships between ablation of distinct haematopoietic cell subsets and the development of donor bone marrow engraftment following recipient pretreatment with different alkylating drugs
3. Transient and permanent engraftment potential of murine hematopoietic stem cell subsets: Different effects of host conditioning with gamma radiation and cytotoxic drugs
4. A comparison of busulphan versus total body irradiation combined with cyclophosphamide as conditioning for autograft or allograft bone marrow transplantation in patients with acute leukemia
5. Allogeneic bone marrow transplantation for acute myeloid leukemia in first remission: A randomized trial of a busulfan-Cytoxan versus Cytoxan-total body irradiation as preparative regimen: A report from the Group d'Etudes de la Greffe de Moelle Osseuse
6. Marrow transplantation for chronic myeloid leukemia: A randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide
7. Busulfan
8. Pharmacology of agents used in bone marrow transplant conditioning regimens
9. Pharmacology of bone marrow transplantation conditioning regimens
10. Aspects concerning busulfan pharmaco-kinetics and bioavailability
11. Cerebrospinal fluid and plasma concentrations of busulfan during high-dose therapy
12. Pulmonary complications of bone marrow transplantation: A comparison of total body irradiation and cyclophosphamide to busulfan and cyclophosphamide
13. Prolonged impairment of hematopoiesis after high-dose therapy followed by autologous bone marrow transplantation
14. Long-term marrow cultures from mice with busulfan-induced chronic latent aplasia
15. Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics
16. Association of busulfan area under the curve with veno-occlusive disease following BMT
17. Dose-dependent neurotoxicity of high-dose busulfan in children: A clinical and pharmacological study
18. Marrow transplantation for chronic myeloid leukemia: The influence of plasma busulfan levels on the outcome of transplantation
19. DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates
20. DNA-DNA interstrand crosslinking by dimethanesul-phonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length
21. Studies with alkylating esters. V. The reactions, metabolism and biological activities of some cyclic dimethanesulphonates: The relevance to the mechanism of action of Myleran
22. Cross-linking between histones and DNA following treatment with a series of dimethane sulphonate esters
23. A physico-chemical investigation into the biological action of Myleran and related sulphonic acid esters
24. The effects of Myleran (1,4-dimethanesulphonyloxybutane) and homologous compounds on the blood
25. Comparison of the mechanism of action of busulfan with Hepsulfam, a new antileukemic agent, in the L1210 cell line
26. Mechanisms of toxicity of hepsulfam in human tumor cell lines
27. In vitro cytotoxicity of hepsulfam against human tumor cell lines and primary human tumor colony forming units
28. Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity
29. Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus
30. In vitro studies on the mechanism of action of hepsulfam in chronic myelogenous leukemia patients
31. The effect of a homologous series of dimethane-sulphonoxy-alkanes on haematopoietic colony forming units in the rat
32. Allogeneic and syngeneic marrow transplantation following high dose dimethylbusulfan, cyclophosphamide and total body irradiation
33. Treosulfan (dihydroxybusulphan) in the management of ovarian carcinoma
34. Treosulfan as an effective second-line therapy in ovarian cancer
35. A Phase I clinical and pharmacokinetic trial of hepsulfam
36. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cell in the mouse
37. Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay
38. Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse
39. Wheat germ agglutinin affinity of murine hemopoietic stem cell subpopulations is an inverse function of their long term repopulating ability in vitro and in vivo
40. Radiation dose as a factor in host preparation for bone marrow transplantation across different genetic barriers
41. Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents
42. The selectivity of action of alkylating agents and drug resistance. III. The uptake and degradation of alkylating drugs by Yoshida ascites sarcoma cells in vitro
43. Variations in radiation sensitivity and repair among different hematopoietic stem cell subsets following fractionated irradiation
44. Crosslinking of DNA by busulfan. Formation of diguanyl derivatives
45. Comparative antitumour and haematological effects of some bifunctional alkylating agents containing mixed functional groups
46. Studies on epoxide formation from (2S,3S)-threitol 1,4- bismethanesulfonate. The preparation and biological activity of (2S,3S)- 1,2-epoxy-3,4-butanediol 4-methanesulfonate
47. DNA alkylation and interstrand cross-linking by treosulfan
48. The effect of combining cyclophosphamide with total-body irradiation on donor bone marrow engraftment
49. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice
50. Bone marrow transplantation in the busulfan-treated rat. 1. Effect of cyclophosphamide and rabbit antirat thymocyte serum as immunosuppression