DNA conformation driven by AP-1 triggers cellspecific expression via a strong epithelial enhancer

EMBO Reports

Volumn 1, Issue 4, 2000, Pages 328-333

  Virolle, Thierry ^a   Djabari, Zied ^a   Ortonne, Jean Paul ^a,b   Aberdam, Daniel ^a  

^a INSERM   (France)

^b Service de Dermatologie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LAMININ; LAMININ ALPHA 3; MESSENGER RNA; THYMIDINE KINASE; TRANSCRIPTION FACTOR AP 1;

ANIMAL; ARTICLE; CELL STRAIN 3T3; CELL STRAIN COS1; CONFORMATION; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; KERATINOCYTE; METABOLISM; MOUSE; PLASMID; PROMOTER REGION; RAT; REGULATORY SEQUENCE; TRANSACTIVATION;

3T3 CELLS; ANIMALS; COS CELLS; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; KERATINOCYTES; LAMININ; MICE; NUCLEIC ACID CONFORMATION; PLASMIDS; PROMOTER REGIONS (GENETICS); RATS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; THYMIDINE KINASE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 0034305789     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd066     Document Type: Article

References (9)

1. Aberdam, D., Aguzzi, A., Baudoin, C, Galliano, M.F., Ortonne, J.P. and Meneguzzi, G. (1994a) Developmental expression of nicein adhesion protein (laminin-5) subunits suggests multiple morphogenic roles. Cell Adhes. Commun., 2, 115-129.
2. Aberdam, D. et al. (1994b) Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/ kalinin (LAMININ-5). Nature Genet., 6, 299-304.
3. Dignam, J.D. and Reeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
4. Ferrigno, O., Virolle, T., Galliano, M.F., Chauvin, N., Ortonne, J.P., Meneguzzi, G. and Aberdam, D. (1997) Murine laminin 5 α3A and α3B isoform chains are generated by usage of two promoters and alternative splicing. J. Biol. Chem., 272, 20502-20508.
5. Galliano, M.F., Aberdam, D., Aguzzi, A., Ortonne, J.P. and Meneguzzi, G. (1995) Cloning and complete primary structure of the mouse laminin α3 chain. Distinct expression pattern of the laminin α3A and α3B chain isoforms. J. Biol. Chem., 270, 21820-21826.
6. Rousselle, P., Lunstrum, G.P., Keene, D.R. and Burgesson, R.E. (1991) Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J. Cell Biol., 114, 567-576.
7. Ryan, M.C., Tizard, R., VanDevanter, D.R. and Carter, W.G. (1994) Cloning of the LamA3 gene encoding the α3 chain of adhesive ligand epiligrin. J. Biol. Chem., 269, 22779-22787.
8. Vailly, J., Gagnoux-Palacios, L., Dellambra, E., Roméro, C., Pinola, M., Zambruno, G., De Luca, M., Ortonne, J.P. and Meneguzzi, G. (1998) Corrective gene transfer of keratinocytes obtained from patients with junctional epidermolysis bullosa restores assemby of hemidesmosomes in reconstructed epithelia. Gene Ther., 5, 1322-1332.
9. Virolle, T., Monthouel, M.N., Djabari, Z., Ortonne, J.P., Meneguzzi, G. and Aberdam, D. (1998) Three AP-1 binding sites bound by Fra-2/JunD complex cooperate for the regulation of the murine laminin α3A (lama3A) promoter activity by transforming growth factor-β. J. Biol. Chem., 273, 17318-17325.