Defining COX-2 inhibitors

Journal of Rheumatology

Volumn 27, Issue SUPPL. 60, 2000, Pages 13-16

  Lipsky, P E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Arthritis; Celecoxib; Cyclooxygenase; Platelet aggregation; Thromboxane; Ulcer

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN;

ARACHIDONIC ACID METABOLISM; ARTHRITIS; CONFERENCE PAPER; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG SELECTIVITY; ENZYME SPECIFICITY; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN CELL; HUMAN TISSUE; OUTCOMES RESEARCH; PRIORITY JOURNAL; ANIMAL; ARTICLE; CLASSIFICATION; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; OSTEOARTHRITIS; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, RHEUMATOID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; OSTEOARTHRITIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SUBSTRATE SPECIFICITY;

EID: 0034304252     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (16)

1. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
2. Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and non-ulcerogenic
3. Pharmacological and biochemical demonstration of the role of cyclooxygenase (COX)-2 in inflammation and pain
4. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation
5. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis
6. Cyclooxygenase-1 and-2 expression in rheumatoid synovial tissues
7. Prostaglandin H synthase isoenzyme selectivity; the potential for safer nonsteroidal anti-inflammatory drugs
8. The discovery and function of COX-2
9. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
10. Expression and selective inhibition of the constitutive and inducible forms of human cyclooxygenase
11. Differential inhibition of human prostaglandin endoperoxide H synthases 1 and 2 by nonsteroidal anti-inflammatory drugs
12. Cyclooxygenase-1 and cyclooygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs
13. Gastrointestinal tract complications of nonsteroidal antiinflammatory drug treatment in rheumatoid arthritis
14. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs
15. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
16. The classification of cyclooxygenase inhibitors