Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 1, Issue 3, 2000, Pages 257-262

  Zhu, Yi Zhun ^a,d   Zhu, Yi Chun ^a,b   Li, Jun ^a   Schäfer, Heiner ^c   Schmidt, Wolfgang ^c   Yao, Tai ^b   Unger, Thomas ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Anglotensin II receptor; Gene transcription; Losartan; Myocardial infarction; Polymerase chain reaction

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT; LOSARTAN; MESSENGER RNA;

ANIMAL; ARTICLE; CORONARY ARTERY BLOOD FLOW; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; HEART INFARCTION; HEART MUSCLE; HEMODYNAMICS; MALE; METABOLISM; PATHOPHYSIOLOGY; RAT; WISTAR RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CORONARY CIRCULATION; HEMODYNAMIC PROCESSES; LOSARTAN; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0034285633     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.3317/jraas.2000.039     Document Type: Article

References (22)

1. Zhu YC, Zhu YZ, Spitznagel H, Gohlke P, Unger Th. Substrate metabolism, hormone interaction, and angiotensin-converting enzyme inhibition in left ventricular hypertrophy. Diabetes 1996; 45(Suppl. 1): S59-S65.
2. Swedberg K, Held P, Kjekshus J, Rasmussen K, Ryden L, Wedel H. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction - Results of the cooperative new Scandinavian enalapril survival study II(CONSENSUS II). N Engl J Med 1992; 327: 678-84.
3. Pfeffer MA, Braunwald E, Moye LA. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction - results of the survival and ventricular enlargement trial. N Engl J Med 1992; 327: 669-77.
4. The acute infarction ramipril efficacy (AIRE) study investigators: Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 1993; 342: 821-8.
5. Dickstein K, Gottlieb S, Fleck et al. Hemodynamic and neurohumoral effects of the angiotensin II antagonist losartan in patients with heart failure. J Hypertens 1994; 12(2): S31-5.
6. Burnier M, Waeber B, Brunner HR. The advantages of angiotensin II antagonist. J Hypertens 1994; 12(2): S7-15.
7. Ford WR, Clanachan AS, Jugdutt BI. Opposite effects of angiotensin AT1-and AT2-receptor antagonists on recovery of mechanical function after ischemia-rcperfusion in isolated working rat hearts. Circulation 1996; 94(12): 3087-9.
8. Kuizinga MC, Smits JFM, Arends JW, Daemen MJAP. AT2-receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarction. J Mol Cell Cardiol 1998; 30(2): 425-34.
9. Csikos T, Chung O, Unger T. Receptors and their classification: focus on angiotensin II and the AT2-receptor. J Hum Hypertens 1998;12(5): 311-8.
10. Reiss K, Capasso JM, Huang HE, Meggs LG, Li P, Anversa P. ANG II receptors, c-myc, and c-jun in myocytes after myocardial infarction and ventricular failure. Am J Physiol 1993; 264(3 pt 2): H760-H769.
11. Nio Y, Matsubara H, Murasawa, S, Kanasaki, M, Inada M. Regulation of gene transcription of Angiotensin II receptor subtypes in myocardial infarction. J Clin Invest 1995; 95: 46-54.
12. Johns TNP, Olson DJ. Experimental myocardial infarction:A method of coronary occlusion in small animals. Ann Surg 1954; 140: 675-82.
13. Stauss B, Itoi K, Stauss H, Unger Th. A novel inexpensive computer system to record and analyze hemodynamic data in conscious animals. Eur J Pharmacol 1990; 183: 863-4.
14. Schäfer H, Trauzold A, Siegel EG, Fölsch U, Schmidt WE. PRG1:a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma. Cancer Res 1996; 56: 2641-8.
15. Pfeffer MA, Braunwald E. Ventricular remodelling after myocardial infarction: experimental observations and clinical implications. Circulation 1990; 81:1161-72.
16. Olivetti G, Capasso JM, Sonnenblick EH. Side-to-side slippage of myocytes participates in ventricular wall remodelling acutely after myocardial infarction in rats. Circ Res 1990; 67: 23-34.
17. Aceto JF, Baker KM. [Sar1] angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol 1990; 258: H806-H813.
18. Baker KM, Aceto JF. Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am J Physiol 1990; 259: H610-H618.
19. Weber KT, Brilla CG, Janicki JS. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res 1993; 27: 341-8.
20. Lindpaintner K, Gantan D. The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence. Circ Res 1992; 68: 905-21.
21. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. J Clin Invest 1990; 86(6): 1913-20.
22. Liu YH, Yang XP, Sharov VG et al. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest 1997;99(8):1926-35.