Synaptic relationship of the neurons containing a metabotropic glutamate receptor, MGluR5, with nociceptive primary afferent and GABAergic terminals in rat spinal superficial laminae

Brain Research

Volumn 875, Issue 1-2, 2000, Pages 138-143

  Tao, Yuan Xiang ^a,b   Li, Yun Qing ^c   Zhao, Zhi Qi ^b   Johns, Roger A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

GABA; Metabotropic glutamate receptor; Primary afferent; Rat; Spinal cord; Ultrastructure

Indexed keywords

4 AMINOBUTYRIC ACID; HORSERADISH PEROXIDASE; METABOTROPIC RECEPTOR; WHEAT GERM AGGLUTININ;

ANIMAL TISSUE; ARTICLE; GABAERGIC TRANSMISSION; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD STAINING; MALE; MUSCLE SPINDLE AFFERENT NERVE; NEUROMODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD BLOOD FLOW; SYNAPSE; ULTRASTRUCTURE;

ANIMALS; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; NERVE ENDINGS; NEURONS; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD; SYNAPSES; WHEAT GERM AGGLUTININ-HORSERADISH PEROXIDASE CONJUGATE;

EID: 0034284568     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02608-1     Document Type: Article

References (29)

1. Abe T., Sugihara H., Nawa H., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J. Biol. Chem. 267:1992;13361-13368.
2. Aanonsen L.M., Wilcox G.L. Muscimol, γ-aminobutyric acid A receptors and excitatory amino Acids in the mouse spinal cord. J. Pharmacol. Exp. Ther. 248:1989;1034-1038.
3. Berthele A., Boxall S.J., Urban A., Anneser J.M., Zieglgansberger W., Urban L., Tolle T.R. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord. Brain Res. Dev. Brain Res. 112:1999;39-53.
4. Carlton S.M., Hayes E.S. Light microscopic and ultrastructural analysis of GABA-immunoreactive profiles in the monkey spinal cord. J. Comp. Neurol. 300:1990;162-182.
5. Fisher K., Coderre T.J. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists. Neuroreport. 7:1996;2743-2747.
6. Fisher K., Coderre T.J. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Pain. 68:1996;255-263.
7. Fisher K., Fundytus M.E., Cahill C.M., Coderre T.J. Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. Pain. 77:1998;59-66.
8. Fundytus M.E., Fisher K., Dray A., Henry J.L., Coderre T.J. In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats. NeuroReport. 9:1998;731-735.
9. Jia H., Rustioni A., Valtschanoff J.G. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn. J. Comp. Neurol. 410:1999;627-642.
10. LaMotte C.C., Kapadia S.E., Shapiro C.M. Central projections of the sciatic, saphenous, median, and ulnar nerves of the rat demonstrated by transganglionic transport of choleragenoid- HRP (B-HRP) and wheat germ agglutinin-HRP (WGA-HRP). J. Comp. Neurol. 311:1991;546-562.
11. Li H., Ohishi H., Kinoshita A., Shigemoto R., Nomura S., Mizuno N. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: an electron microscope study in the rat. Neurosci. Lett. 223:1997;153-156.
12. Neki A., Ohishi H., Kaneko T., Shigemoto R., Nakanishi S., Mizuno N. Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience. 75:1996;815-826.
13. Neugebauer V., Lucke T., Schaible H.G. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons. Eur. J. Neurosci. 6:1994;1179-1186.
14. Ohishi H., Nomura S., Ding Y.Q., Shigemoto R., Wada E., Kinoshita A., Li J.L., Neki A., Nakanishi S., Mizuno N. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat. Neurosci. Lett. 202:1995;85-88.
15. Pin J.P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
16. Reeve A.J., Walker K., Kuhn R., Urban L. Peripheral metabotropic glutamate receptor subtype 5-mediated activation of rat dorsal horn wide-dynamic range neurons in vivo: selective inhibition by 2-methyl-6-(phenylethynyl)-pyridine (MPEP). Neuroscience abstract. 25:1999;449.
17. Robertson B., Grant G. A comparison between wheat germ agglutinin- and choleragenoid-horseradish peroxidase as anterogradely transported markers in central branches of primary sensory neurones in the rat with some observations in the cat. Neuroscience. 14:1985;895-905.
18. Shigemoto R., Kinoshita A., Wada E., Nomura S., Ohishi H., Takada M., Flor P.J., Neki A., Abe T., Nakanishi S., Mizuno N. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci. 17:1997;7503-7522.
19. Shigemoto R., Nomura S., Ohishi H., Sugihara H., Nakanishi S., Mizuno N. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett. 163:1993;53-57.
20. Stanfa L.C., Dickenson A.H. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. Eur. J. Pharmacol. 347:1998;165-172.
21. Tao Y.X., Zhao Z.Q. Ultrastructure of Fos-labeled neurons relating to nociceptive primary afferent and substance P terminals in rat spinal superficial laminae. Neuropeptides. 31:1997;327-332.
22. Todd A.J. GABA and glycine in synaptic glomeruli of the rat spinal dorsal horn. Eur J. Neurosci. 8:1996;2492-2498.
23. Vidnyanszky Z., Hamori J., Negyessy L., Ruegg D., Knopfel T., Kuhn R., Gorcs T.J. Cellular and subcellular localization of the mGluR5a metabotropic glutamate receptor in rat spinal cord. Neuroreport. 6:1994;209-213.
24. Wada E., Shigemoto R., Kinoshita A., Ohishi H., Mizuno N. Metabotropic glutamate receptor subtypes in axon terminals of the projection fibers from the main and accessory olfactory bulbs: light and electron microscopic immunohistochemical study in the rat. J. Comp. Neurol. 393:1998;493-504.
25. Walker K., Bowes M., Winter J., Gasparini F., Schmid P., Kuhn R., Urban L. Metabotropic glutamate receptors, subtype 5, expressed on sensory neurons in rat skin mediate inflammatory hyperalgesia. Neuroscience abstract. 25:1999;449.
26. Weinberg R.J., van Eyck S.L. A tetramethylbenzidine/tungstate reaction for horseradish peroxidase histochemistry. J. Histochem. Cytochem. 39:1991;1143-1148.
27. Willcockson W.S., Chung J.M., Hori Y., Lee K.H., Willis W.D. Effects of iontophoretically released peptides on primate spinothalamic tract cells. J. Neurosci. 4:1984;741-750.
28. Willis W.D., Coggeshall R.E. Sensory mechanisms of the spinal cord. 2nd Edition :1991;Plenum Press, New York.
29. Young M.R., Fleetwood-Walker S.M., Dickinson T., Blackburn-Munro G., Sparrow H., Birch P.J., Bountra C. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain Res. 777:1997;161-169.