Is there a relationship between 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and forebrain pathology in the PKU mouse?

Journal of Neuroscience Research

Volumn 61, Issue 5, 2000, Pages 549-563

  Shefer, Sarah ^a   Tint, G Stephen ^a,b   Jean Guillaume, Danielle ^c   Daikhin, Evgueni ^c   Kendler, Ady ^d   Nguyen, Lien B ^a   Yudkoff, Marc ^c   Dyer, Charissa A ^c,e  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cholesterol; Hypomyelination; Myelin; Oligodendrocyte; PKU mouse

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CHOLESTEROL; PHENYLALANINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MICROSOME; CHOLESTEROL SYNTHESIS; DOWN REGULATION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FOREBRAIN; GENETIC MODEL; GLIOMA CELL; MICROSOME; MOUSE; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PHENYLKETONURIA; PRIORITY JOURNAL; WHITE MATTER;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BRAIN CHEMISTRY; CELL COUNT; CELL LINE; CHOLESTEROL; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; FARNESYLTRANSTRANSFERASE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MICROSOMES; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIAS; PROSENCEPHALON; RHOMBENCEPHALON;

EID: 0034283890     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20000901)61:5<549::AID-JNR10>3.0.CO;2-0     Document Type: Article

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