Transfer of IFNγ-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice

International Journal of Cancer

Volumn 87, Issue 5, 2000, Pages 673-679

  Klugewitz, Katja ^a,c   Scheffold, Alexander ^b   Radbruch, Andreas ^b   Hamann, Alf ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c Experimentelle Rheumatologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; CANCER VACCINE; INTERLEUKIN 10; VIRUS T ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL POLARITY; CELL SELECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; KIDNEY SARCOMA; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; T LYMPHOCYTE ACTIVATION; TUMOR GROWTH; TUMOR IMMUNITY; VACCINATION; ADOPTIVE IMMUNOTHERAPY; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; CD8+ T LYMPHOCYTE; CYTOLOGY; FEMALE; GRAFT REJECTION; IMMUNOLOGY; KIDNEY TUMOR; METABOLISM; PATHOLOGY; PERITONEAL CAVITY; PHENOTYPE; REGULATORY T LYMPHOCYTE; SARCOMA; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, VIRAL, TUMOR; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GRAFT REJECTION; IMMUNOTHERAPY, ADOPTIVE; INTERFERON TYPE II; INTERLEUKIN-10; KIDNEY NEOPLASMS; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PERITONEAL CAVITY; PHENOTYPE; SARCOMA, EXPERIMENTAL; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 0034266072     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000901)87:5<673::AID-IJC9>3.0.CO;2-H     Document Type: Article

References (27)

1. ASSENMACHER, M., SCHEFFOLD, A., SCHMITZ, J., CHECA, J.S., MILTENYI, S. and RADBRUCH, A., Specific expression of surface interferon on interferon producing T cells from mouse and man. Europ. J. Immunol., 26, 263-267 (1996).
2. BOON, T., COULIE, P.G. and VAN DEN EYNDE, B., Tumor antigens recognized by T cells. Immunol. Today, 18, 267-268 (1997).
3. BRIGHT, R.K., SHEARER, M.H. and KENNEDY, R.C., Immunization of BALB/c mice with recombinant simian virus 40 large. J. Immunol., 153, 2064-2071 (1994).
4. BRIGHT, R.K., SHEARER, M.H. and KENNEDY, R.C., Examination of lymphokines induced in mice following immunization with recombinant simian virus 40 large tumor antigen. Cancer Immunol. Immunother., 40, 206-211 (1995).
5. FANNING, E. and KNIPPERS, R., Structure and function of simian virus 40 large tumor antigen. Annu. Rev. Biochem., 61, 55-85 (1992).
6. GROUX, H., BIGLER, M., DE VRIES, J.E. and RONCAROLO, M.G., Inhibitory and stimulatory effects of IL-10 on human CD8 T cells. J. Immunol., 160, 3188-3193 (1998).
7. GROUX, H., COTTREZ, F., ROULEAU, M., MAUZE, S., ANTONENKO, S., HURST, S., MCNEIL, T., BIGLER, M., RONCAROLO, M.G. and COFFMAN, R.L., A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. J. Immunol., 162, 1723-1729 (1999).
8. HOWARD, M. and O'GARRA, A., Biological properties of IL-10. Immunol. Today, 13, 198-200 (1992).
9. HU, H.M., URBA, W.J. and FOX, B.A., Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from a type 2 to a type 1 cytokine profile. J. Immunol., 161, 3033-3041 (1998).
10. KIT, S., KURIMURA, T. and DUBBS, D.R., Transplantable mouse tumor line induced by injection of SV40-transformed mouse kidney cells. Int. J. Cancer, 4, 384-392 (1969).
11. + tumor immunosurveillance and regulation of tumor escape by CD4 T-cells through an effect on the quality of CTL. J. Immunol. 163, 184-193 (1999).
12. MELIEF, C.J., Tumor eradication by adoptive transfer of cytotoxic T lymphocytes. Adv. Cancer Res., 58, 143-175 (1992).
13. MOSMANN, T.R., CHERWINSKI, H., BOND, M.W., GIEDLIN, M.A. and COFFMAN, R.L., Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol., 136, 2348-2357 (1986).
14. + T cells as Th1 cells based on lymphokine secretion and functional properties. J. Immunol. 144, 4898-4905 (1990).
15. NISHIMURA, T., IWAKABE, K., SEKIMOTO, M., OHMI, Y., YAHATA, T., NAKUI, M., SATO, T., HABU, S., TASHIRO, H., SATO, M. and OHTA, A., Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo. J. Exp. Med., 190, 617-627 (1999).
16. PENG, L., SHU, S. and KRAUSS, J.C., Treatment of subcutaneous tumor with adoptively transferred T cells. Cell. Immunol., 178, 24-32 (1997).
17. RODOLFO, M., ZILOCCHI, C., ACCORNERO, P., CAPPETTI, B., ARIOLI, I. and COLOMBO, M., IL-4-transduced tumor cell vaccine induces immunoregulatory type 2 CD8 lymphocytes that cure lung metastases upon adoptive transfer. J. Immunol., 163, 1923-1928 (1999).
18. ROSENSTEIN, M., EBERLEIN, T.J. and ROSENBERG, S.A., Adoptive immunotherapy of established syngeneic solid tumors: role of T lymphoid subpopulations. J. Immunol., 132, 2117-2122 (1984).
19. SANTRA, S., and GHOSH, S.K., Interleukin-4 is effective in restoring cytotoxic T cell activity that declines during in vivo progression of a murine B lymphoma. Cancer Immunol. Immunother., 44, 291-300 (1997).
20. SCHEFFOLD, A., ASSENMACHER, M., REINERS-SCHRAMM, L., LAUSTER, R. and RADBRUCH, A., High sensitivity immunofluorescence for detection of the pro-and anti-inflammatory cytokines IFN gamma and IL-10 on the surface of cytokine secreting cells. Nature (Med.), 6, 107-110 (2000).
21. SCHEFFOLD, A., MILTENYI, S. and RADBRUCH, A., Magnetofluorescent liposomes for increased sensitivity of immunofluorescence. Immunotechnology, 1, 127-137 (1995).
22. + cytotoxic T lymphocytes in mice. Europ. J. Immunol. 22, 759-766 (1992).
23. SCOTT, P., NATUVITZ, P., COFFMAN, R.L., PEARCE, E. and SHER, A., Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med., 168, 1675-1684 (1988).
24. SEO, N. and TOKURA, Y., Downregulation of innate acquired antitumor immunity by bystander gamma/delta and alpha/beta T lymphocytes with Th2 or Th1 cytokine profiles. J. Interferon Cytokine Res., 19, 555-561 (1999).
25. SHEARER, M.H., BRIGHT, R.K., LANFORD, R.E. and KENNEDY, R.C., Immunization of mice with baculovirus-derived recombinant SV40 large tumour antigen induces protective tumour immunity to a lethal challenge with SV40-transformed cells. Clin. Exp. Immunol., 91, 266-271 (1993).
26. TEPPER, R.I., PATTENGALE, P. and LEDER, P., Murine interleukin-4 displays a potent anti-tumor activity in vivo. Cell, 57, 503-512 (1989).
27. + T lymphocytes. J. Immunol., 156, 3919-3924 (1996).