Formation of abasic sites in DNA by t-butyl peroxyl radicals: Implication for potent genotoxicity of lipid peroxyl radicals

Cancer Letters

Volumn 156, Issue 1, 2000, Pages 51-55

  Kanazawa, Ayako ^a   Sawa, Tomohiro ^b   Akaik, Takaaki ^b   Maeda, Hiroshi ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Abasic site; Alkyl peroxyl radical; DNA modification

Indexed keywords

DNA; FREE RADICAL; HEMOGLOBIN; PEROXY RADICAL; TERT BUTYL HYDROPEROXIDE;

ARTICLE; CATTLE; DNA DAMAGE; DNA MODIFICATION; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL; THYMUS;

DNA; HEMOGLOBINS; LIPID PEROXIDES; MUTATION; PEROXIDES; TERT-BUTYLHYDROPEROXIDE;

EID: 0034257183     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00439-0     Document Type: Article

References (24)

1. Halliwell B. Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: Measurement, mechanism and the effects of nutrition. Mutat. Res. 443:1999;37-52.
2. Loeb L.A., Cheng K.C. Errors in DNA synthesis: A source of spontaneous mutations. Mutat. Res. 238:1990;297-304.
3. Loechler E.L. The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: Perspective, prospects and problems. Carcinogenesis. 17:1996;895-902.
4. Burcham P.C. Genotoxic lipid peroxidation products: Their DNA damaging properties and role in formation endogenous DNA adducts. Mutagenesis. 13:1998;287-305.
5. Willett W.C., Stampfer M.J., Colditz G.A., Rosner B.A., Speizer F.E. Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N. Engl. J. Med. 323:1990;1664-1672.
6. Sinha R., Kulldorff M., Curtin J., Brown C.C., Alavanja M.C., Swanson C.A. Fried, well-done red meat and risk of lung cancer in women (United States). Cancer Causes Control. 9:1998;621-630.
7. Sawa T., Akaike T., Kida K., Fukushima Y., Takagi K., Maeda H. Lipid peroxyl radicals from oxidized oils and heme-iron: Implication of a high-fat diet in colon carcinogenesis. Cancer Epidemiol. Biomarkers Prev. 7:1998;1007-1012.
8. Davies M.J., Slater T.F. Studies on the metal-ion and lipoxygenase-catalyzed breakdown of hydroperoxides using electron-spin-resonance spectroscopy. Biochem. J. 245:1987;167-173.
9. Akaike T., Sato K., Ijiri S., Miyamoto Y., Kohno M., Ando M., Maeda H. Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides. Arch. Biochem. Biophys. 294:1992;55-63.
10. Akaike T., Ijiri S., Sato K., Katsuki T., Maeda H. Determination of peroxyl radical-scavenging activity in food by using bactericidal action of alkyl peroxyl radical. J. Agric. Food Chem. 43:1995;1864-1870.
11. Peak M.J., Peak J.G. Hydroxyl radical quenching agents protect against DNA breakage caused by both 365-nm UVA and by γ-radiation. Photochem. Photobiol. 51:1990;1090-1095.
12. Salgo M.G., Stone K., Squadrito G.L., Battista J.R., Pryor W.A. Peroxynitrite causes DNA nicks in plasmid pBR322. Biochem. Biophys. Res. Commun. 210:1995;1025-1030.
13. Kubo K., Ide H., Wallace S.S., Kow Y.W. A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion. Biochemistry. 31:1992;3703-3708.
14. Harkin L.A., Butler L.M., Burcham P.C. Role of G→T transversions in the mutagenicity of alkylperoxyl radicals: Induction of alkali-labile sites in bacteriophage M13mp19. Chem. Res. Toxicol. 10:1997;575-581.
15. Martini M., Termini J. Peroxy radical oxidation of thymidine. Chem. Res. Toxicol. 10:1997;234-241.
16. Valentine M.R., Rodriguez H., Termini J. Mutagenesis by peroxy radical is dominated by transversions at deoxyguanosine: Evidence for the lack of involvement of 8-oxo-dG′ and/or abasic site formation. Biochemistry. 37:1998;7030-7038.
17. Mylonas C., Kouretas D. Lipid peroxidation and tissue damage. In Vivo. 13:1999;295-310.
18. Harkin L.A., Burcham P.C. Formation of novel C′-oxidised abasic sites in alkylperoxyl radical-damaged plasmid DNA. Biochem. Biophys. Res. Commun. 237:1997;1-5.
19. Niki E. Free radical initiators as source of water- or lipid-soluble peroxyl radicals. Methods Enzymol. 186:1990;100-108.
20. Lossius I., Kruger P.G., Kleppe K. Effect of methyl methanesuphonate on the nucleoid structure of Escherichia coli. J. Gen. Microbiol. 124:1981;159-171.
21. Hutchinson F. Chemical changes induced in DNA by ionizing radiation. Prog. Nucleic Acid Res. Mol. Biol. 32:1985;115-154.
22. Cabral Neto J.B., Cabral R.E.C., Margot A., Le Page F., Sarasin A., Gentil A. Coding properties of a unique apurinic/apyrimidinic site replicated in mammalian cells. J. Mol. Biol. 240:1994;416-420.
23. Kamiya H., Suzuki M., Komatsu Y., Miura H., Kikuchi K., Sakaguchi T., Murata N., Masutani C., Hanaoka F., Ohtsuka E. An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions. Nucleic Acids Res. 20:1992;4409-4415.
24. Chakravarti D., Pelling J.C., Cavalieri E.L., Rogan E.G. Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: The role of apurinic sites. Proc. Natl. Acad. Sci. USA. 92:1995;10422-10426.