Evaluation and comparison of ion permeation and agonist selectivities for N-methyl-D-mspartate receptor channels with different subunit compositions in Bilayer Lipid Membranes based on integrated single-channel currents

Analytical Biochemistry

Volumn 283, Issue 2, 2000, Pages 258-265

  Hirano, Ayumi ^a   Wakabayashi, Masaki ^a   Sugawara, Masao ^a   Uchino, Shigeo ^b   Nakajima Iijima, Sadayo ^b  

^a NIHON UNIVERSITY   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Agonist selectivity.; Bilayer lipid membrane.; Ion permeation.; NMDA receptor.; Single channel recording

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOPHYSICS; CELL MEMBRANES; IONS; LIPIDS; PLANTS (BOTANY); SIGNAL TRANSDUCTION;

BILAYER LIPID MEMBRANE; BINDING AFFINITIES; CHINESE HAMSTER OVARY CELLS; INTEGRATED CURRENTS; ION PERMEATION; N-METHYL-D-ASPARTATE; NMDA RECEPTOR; SINGLE CHANNEL RECORDING;

PERMEATION;

2 (CARBOXYCYCLOPROPYL)GLYCINE; GLUTAMIC ACID; LIPID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; ION PERMEABILITY; LIPID MEMBRANE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0034255424     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4650     Document Type: Article

References (32)

1. N-methyl-D-aspartic acid receptor structure and function
2. A synaptic model of memory: Long-term potentiation in the hippocampus
3. Cloning, expression and modulation of a mouse NMDA receptor subunit
4. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
5. Molecular diversity of the NMDA receptor channel
6. Cloning and expression of the ε4 subunit of the NMDA receptor channel
7. Developmental changes in distribution of NMDA receptor channel subunit mRNAs
8. Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors
9. Inducible expression of N-methyl-D-aspartate (NMDA) receptor channels from cloned cDNAs in CHO cells
10. Single-channel activations and concentration jumps: Comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors
11. Single channel properties of cloned NMDA receptors in a human cell line: Comparison with results from Xenopus oocytes
12. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
13. Single-channel conductances of NMDA receptors expressed from cloned cDNAs: Comparison with native receptors
14. Ion permeation properties of the cloned mouse ε2/ζ1 NMDA receptor channel
15. Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel
16. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
17. Ifenprodil discriminates subtypes of N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
18. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits
19. Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells
20. Stable expression and characterization of recombinant human heteromeric N-methyl-D-aspartate receptor subtypes NMDAR1A/2A and NMDAR1A/2B in mammalian cells
21. Functional reconstitution of N-methyl-D-aspartate receptors in artificial lipid bilayers
22. Reconstitution of glutamate receptor proteins purified from Xenopus central nervous system into artificial bilayers
23. Ion channel properties of a protein complex with characteristics of a glutamate/N-methyl-D-aspartate receptor
24. Electrochemical evaluation of chemical selectivity of glutamate receptor ion channel proteins with a multi-channel sensor
25. Evaluation of agonist selectivity for the NMDA receptor ion channel in bilayer lipid membranes based on integrated single-channel currents
26. Phospholipid bilayers made from monolayers on patch-clamp pipettes
27. 2+ ions through the mouse ε2/ζ1 NMDA receptor channel expressed in Xenopus oocytes
28. Subconductance states of a mutant NMDA receptor channel. Kinetics, calcium, and voltage dependence
29. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurons in culture
30. The glutamate receptor ion channels
31. Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition