Pulmonary function and adrenal gland suppression with incremental doses of aerosolized beclomethasone dipropionate in horses with recurrent airway obstruction

Journal of the American Veterinary Medical Association

Volumn 217, Issue 3, 2000, Pages 359-364

  Rush, Bonnie R ^a   Raub, Elizabeth S ^a   Thomsen, Molly M ^a   Davis, Elizabeth G ^a   Matson, Charles J ^b   Hakala, Joyce E ^b  

^a KANSAS STATE UNIVERSITY   (United States)

^b 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; HYDROCORTISONE;

ADRENAL SUPPRESSION; AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG EFFICACY; HORSE; HYDROCORTISONE BLOOD LEVEL; LUNG FUNCTION; NONHUMAN;

EID: 0034255110     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2000.217.359     Document Type: Article

References (27)

1. Reed CE. Aerosol glucocorticoid treatment of asthma. Am Rev Respir Dis 1990;141:82-88.
2. Barnes PJ, Pedersen S, Busse WW. Efficacy and safety of inhaled corticosteroids. New developments. AM J Resp Crit Care Med 1998;157(suppl):1-53.
3. Reed CE. Aerosol steroids as primary treatment of mild asthma. N Engl J Med 1991;325:425-426.
4. Hanania NA, Chapman KR, Kesten S. Adverse effects of inhaled corticosteroids. Am J Med 1995;98:196-209.
5. Rush BR, Flaminio MJBF, Matson CJ, et al. Cytologic evaluation of bronchoalveolar lavage fluid in horses with recurrent airway obstruction alter aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1033-1038.
6. Rush BR, Raub ES, Rhoads WS, et al. Pulmonary function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1039-1043.
7. Amann VJ, Vrins AA, Lavoie JP. Effects of inhaled beclomethasone dipropionate on respiratory function in horses with chronic obstructive pulmonary disease (COPD). Equine Vet J 1998; 30:152-157.
8. Rush BR, Trevino IC, Matson CJ, et al. Serum Cortisol concentration in response to incremental doses of inhaled beclomethasone dipropionate. Equine Vet J 1999;31:258-261.
9. Rush BR, Worster AA, Flaminio MJBF, et al. Alteration in adrenocortical function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59: 1044-1047.
10. Tesarowski DB, Viel L, McDonell WN. Pulmonary function measurements during repeated environmental challenge of horses with recurrent airway obstruction (heaves). Am J Vet Res 1996; 57:1214-1219.
11. Derksen FJ, Olszewski M, Robinson NE, et al. Use of a hand-held, metered-dose aerosol delivery device to administer pirbuterol acetate to horses with heaves. Equine Vet J 1996;28:306-310.
12. Robinson NE, Derksen FJ, Berney C, et al. The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide. Equine Vet J 1993; 25:299-303.
13. Lapointe JM, Lavoie JP, Vrins AA. Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease. Am J Vet Res 1991;54:1310-1316.
14. Amdur MA, Mead J. Mechanics of respiration in unanesthetized guinea pigs. Am J Physiol 1958;192:364-368.
15. Derksen FJ, Olszewski MA, Robinson NE, et al. Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction Am J Vet Res 1999;60:689-693.
16. Rush BR, Hoskinson JJ, Davis EG, et al. Pulmonary distribution of aerosolized technetium Tc 99m pentetate after administration of a single-dose of aerosolized albuterol sulfate in horses with recurrent airway obstruction. Am J Vet Res 1999;60:764-769.
17. Sherrington CA, Mallol J. Early effects of inhaled steroids on airway hyperreactivity and pulmonary function in asthma. Pediatr Pulmonol 1999;27:376-382.
18. Boe J, Bakke P, Rodolen T, et al. High-dose inhaled steroids in asthmatics: moderate efficacy gain and suppression of the hypthalamic-pituitary-adrenal (HPA) axis. Research Council of the Norwegian Thoracic Society. Eur Respir J 1994;7:2179-2184.
19. Hummel S, Lehtonen L. Comparison of oral-steroid sparing by high-dose and low-dose inhaled steroid in maintenance treatment of severe asthma. Lancet 1992;340:1483-1487.
20. Carpentiere G, Marino S, Castello F, et al. Dose-related effects of beclomethasone dipropionate on airway responsiveness in asthma. Respiration 1990;57:100-103.
21. Grebe SK, Feek CM. Durham JA, et al. Inhaled beclomethasone dipropionate suppresses the hypothalamo-pituitary-adrenal axis in a dose dependent manner. Clin Endocrinol 1997;47:297-304.
22. Chrousos GP, Harris AG. Hypothalamic-pituitary-adrenal axis suppression and inhaled corticosteroid therapy. Review of the literature. Neuroimmunomodulation 1998;5:288-308.
23. Raker CW, Boles CL. Pharyngeal lymphoid hyperplasia in the horse. J Equine Med Surg 1978;2:202-207.
24. Scale JP, Harrison LI. Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics. Respir Med 1998;92(suppl A):9-15.
25. Davies R. Improvements in delivery with an extra fine beclomethasone aerosol. Int J Clin Pract Suppl 1998;96:28-32.
26. Thompson PJ, Davies RJ, Young WF, et al. Safety of hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol. Respir Med 1998;92:33-39.
27. Harrison LI, Colice GL, Donnell D, et al. Adrenal effects and pharmacokinetics of CFC-free beclomethasone dipropionate: a 14-day dose-response study. J Pharm Pharmacol 1999;51:263-269.