Adrenal effects and pharmacokinetics of CFC-free beclomethasone dipropionate: A 14-day dose-response study

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 3, 1999, Pages 263-269

  Harrison, Lester I ^a   Colice, Gene L ^a   Donnell, David ^c   Soria, Inmaculada ^a   Dockhorn, Robert ^b  

^a 3M COMPANY   (United States)

^b Pharmaceutical Research Associates Inc   (United States)

^c 3M Centre Building 270 3S 05 ^*

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; CHLOROFLUOROCARBON; HYDROCORTISONE;

ADRENAL FUNCTION; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; HYDROCORTISONE URINE LEVEL; INHALATIONAL DRUG ADMINISTRATION; MALE; NAUSEA; PHARYNGITIS; RANDOMIZED CONTROLLED TRIAL;

EID: 0032960626     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772439     Document Type: Article

References (19)

1. Barnes, N. (1998) Relative safety and efficacy of inhaled corticosteroids. J. Allergy Clin. Immunol. 101: S460-S464
2. Clark, D. J., Lipworth, B. J. (1997) Adrenal suppression with chronic dosing of fluticasone propionate compared with budesonide in adult asthmatic patients. Thorax 52: 55-58
3. Davies, R. J., Stampone, P., O'Connor, B. J. (1998) Hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol provides equivalent asthma control to chlorofluoro-carbon beclomethasone dipropionate at approximately half the total daily dose. Respir. Med. 92 (Suppl. A): 23-31
4. Fairfax, A. J., Donnell, D., Song, W. (1997) CFC-free beclomethasone aerosol has improved therapeutic ratio. Eur. Respir. J. 10 (Suppl.): 126s-127s
5. Falcoz, C., Kirby, S. M., Smith, J., Olsson, P., Ventresca, G. P. (1996) Pharmacokinetics and systemic exposure of inhaled beclomethasone dipropionate. Eur. Respir. J. 9 (Suppl. 23): 162s
6. Gibaldi, M., Perrier, D. (1982) Pharmacokinetics. 2nd edn., Marcel Dekker, New York, pp 1-42, 113-143
7. Gross, G., Chervinsky, P., Ramsdell, J., Vanden Burgt, J. (1997) Half the daily dose of new CFC-free formulation steroid achieves equivalent pulmonary function in moderate asthma. Am. J. Respir. Crit. Care Med. 155: A666
8. Hamid, Q., Song, Y., Kotsimbos, T. C., Minshall, E., Bai, T. R., Hegele, R. G., Hogg, J. C. (1997) Inflammation of small airways in asthma. J. Allergy Clin. Immunol. 100: 44-51
9. Harrison, L., Soria, I., Machacek, J., Jacobson, J., Purrington, A., Cline, A., McCarville, S., Grassell, J., Dahl, D., Wells, T., Chang, S., Howland, W. (1996) Beclomethasone pharmacokinetics in asthmatics given CFC and CFC-free inhalers. Eur. Respir. J. 9 (Suppl. 23): 256s
10. Harrison, L. I., Dahl, D. R., Cline, A., Chang, S. F., Machacek, J., Nelson, J., Kannianinen, C., Purrington, A. (1997) Pharmacokinetics and dose proportionality of beclomethasone from three strengths of a CFC-free beclomethasone dipropionate metered-dose inhaler. Biopharm. Drug Disposit. 18: 635-643
11. Jonckheere, A. R. (1954) A distribution-free K-sample test against ordered alternatives. Biometrika 41: 133-145
12. Keller, M., Kraus, H., Comparone, A., Herzog, K. (1997) Dose-uniformity and aerodynamic particle size distribution of a novel beclomethasone-dipropionate metered dose inhaler powered by non-CFC propellants. Pharm. Res. 14 (Suppl.): S-131
13. Leach, C. L. (1998) Improved delivery of inhaled steroids to the large and small airways. Respir. Med. 92 (Suppl. A): 3-8
14. Lipworth, B. J., Secki, J. R. (1997) Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids. Thorax 52: 476-482
15. Lönnebo, A., Grahnén, A., Jansson, B., Brundin, R. M., Ling-Andersson, A., Eckernäs, S.-Å. (1996) An assessment of the systemic effects of single and repeated doses of inhaled fluticasone propionate and inhaled budesonide in healthy volunteers. Eur. J. Clin. Pharmacol. 49: 459-463
16. Seale, J. P., Harrison, L. I. (1998) Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics. Respir. Med. 92 (Suppl. A): 9-15
17. Thompson, P. J. (1998) Drug delivery to the small airways. Am. J. Respir. Crit. Care Med. 157: S199-S202
18. Thorsson, L., Dahlström, K., Edsbäcker, S., Källén, A., Paulson, J., Wirén, J.-E. (1997) Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects. Br. J. Clin. Pharmacol. 43: 155-161
19. Würthwein, G., Rohdewald, P. (1990) Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm. Drug Disposit. 11: 381-394