2-(1-Hydroxyiminoalkyl)-1,4-dimethoxy-9,10-anthraquinones: Synthesis and Evaluation of Cytotoxicity

Archives of Pharmacal Research

Volumn 23, Issue 4, 2000, Pages 283-287

  Tam, Mai Ngoc ^b   Nam, Nguyen Hai ^b   Jin, Guang Zhu ^c   Ahn, Byung Zun ^a  

^a Chungnam National University   (South Korea)

^b Institute of Material Science   (Viet Nam)

^c YANBIAN UNIVERSITY   (China)

Author keywords

Anthraquinones; Cytotoxicity; Structure activity relationship; Water solubility

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT;

ANIMAL; ARTICLE; CELL CULTURE; HUMAN; LEUKEMIA L 1210; LUNG TUMOR; MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; HUMANS; LEUKEMIA L1210; LUNG NEOPLASMS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034251905     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975436     Document Type: Article

References (9)

1. Higuchi, T., and Connors, K. A., Efficient method for measurement of water solubility of organic compounds. Adv. Anal. Chem. Instrum. 4, 117-212 (1965).
2. Jin, G. Z., Doctorate Dissertation, Synthesis of 2-Substituted-1,4-Dioxy-9,10-Anthraquinones and 2-Substituted-1,4, 9,10-Anthradiquinones Analogues and Evaluation of Their Antitumor Activities, Chungnam National University, Taejon, Korea, p. 45-51, 1997.
3. Jin, G. Z., Song, G. Y., Zheng, S. G., Kim, Y., Sok, D. E., and Ahn, B. Z., 2- (1-Oxyalkyl)-1,4-dioxy-9,10-anthraquinones: Synthesis and Evaluation of Antitumor Activity. Arch. Pharm. Res. 21, 208-206 (1998).
4. Parli, C. J., Wang, N., and McHahon, R. E., The enzymatic Hydroxylation of an imine: A new cytochrome P-450-dependent Reaction catalyzed by hepatic microsomal monooxygenases. J. Biol. Chem. 246, 3587-3593 (1971).
5. Skehan, P., Storeng, R., Scudiero, D., Monk, A., MacMahon, J., Vistica, D., Warren, J., Bokesch, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer Inst. 82, 1107-1112 (1990).
6. Song, G. Y., Doctorate Dissertation, 5,8-Dioxy-1,4-naphthoquinone Derivatives: Synthesis, Inhibition of the DNA topoisomerase-1 and Evaluation of Antitumor Activity, Chungnam National University, Taejon, Korea, p. 112-113, 1998.
7. Song, G. Y., Kim, Y., You, Y. J., Cho, H., Kim, S. H., Sok, D. E., and Ahn, B. Z., Naphthazarin derivatives (II): Synthesis, inhibitory effect on DNA topoisomerase-1 and antiproliferative activity of 2- or 6-(1-oxyirninoalkyl)-5,8-dimethoxy-1,4-naphthoquinones. Arch. Pharm. Pharm. Med. Chem., 333, 87-92 (2000).
8. Song, G. Y., Zheng, X. G., Kim, Y., You, Y. J., Sok, D. E., and Ahn, B. Z., Naphthazarin derivatives (II): Formation of glutathione conjugate, inhibition of DNA topoisomerase-1 and cytotoxicity. Bioorg. Chem. Med. Chem. Lett. 9, 2407-2412 (1999).
9. Thayer, P. S., Himnelfarb, L. A., Watt, G. L., Cytotoxicity assays with L 1210 cells in vitro: comparison with L 1210 in vivo and KB cells in vitro. Cancer Chemo-therapy 2, 1-25 (1971).