Localization of the human SP3 gene to chromosome 7p14-p15.2. The lack of expression in multiple sclerosis does not reflect abnormal gene organization

Journal of Neuroimmunology

Volumn 106, Issue 1-2, 2000, Pages 214-219

  Grekova, Maria C ^a   Scherer, Stephen W ^b   Trabb, Jeffrey ^a   Richert, John R ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Chromosomal localization; FISH; Multiple sclerosis; PCR; Sp3

Indexed keywords

DNA; TRANSCRIPTION FACTOR SP3;

ADULT; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 7P; CHROMOSOME MAP; CLINICAL ARTICLE; CONTROLLED STUDY; COSMID; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; HYBRID CELL; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; BLOTTING, SOUTHERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 7; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE LIBRARY; GENOME; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MONOCYTES; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 0034237431     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00264-7     Document Type: Article

References (15)

1. Birnbaum M., vanWijnen A., Odgren P., Last T., Suske G., Stein G., Stein J. Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3. Biochemistry. 34:1995;16503-16508.
2. Grekova M., Robinson E., Faerber M., Katz P., McFarland H., Richert J. Deficient expression in multiple sclerosis of the inhibitory transcription factor Sp3 in mononuclear blood cells. Ann Neurol. 40:1996;108-112.
3. Hagen G., Muller S., Beato M., Suske G. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1, related genes. Nucleic Acids Res. 20:1992;5519-5525.
4. Haines J.L., Ter-Minassian A., Bazyk J.F., et al. Complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nature Genet. 13:1996;469-471. 25 other authors.
5. Heng H.H.Q., Tsui L.-C. Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma. 102:1993;325-332.
6. Heng H.H.Q., Squire J., Tsui L.-C. High resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc natl Acad Sci, USA. 89:1992;9509-9513.
7. Imataka H., Sogawa K., Yasumoto K., Kikuchi Y., Sasano K., Kobayashi A., Hayami M., Fujii-Kuriyama Y. Two regulatory proteins that bind to the basic transcription element BTE, a box sequence in the promoter region of the rat p-4501A1 gene. EMBO J. 11:1992;3663-3671.
8. Ioannou P.A., Amemiya C.T., Garnes J., Kroisel P.M., Shizuya H., Chen C., Batzer M.A., de Jong P.J. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nature Genet. 6:1994;84-88.
9. Kalff-Suske M., Kunz J., Grzeschik K., Suske G. Human Sp3 transcriptional regulator gene (SP3) maps to chromosome 2q 31. Genomics. 37:1996;410-412.
10. Kingsley C., Winoto A. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol Cell Biol. 12:1992;4251-4261.
11. Kurtzke J.F. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol Rev. 6:1993;382-427.
12. Majello B., De Luca P., Hagen G., Suske G., Lania L. Different members of the Sp3 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. Nucleic Acids Res. 22:1994;4914-4921.
13. Oksenberg J., Hauser S. New insights into the immunogenetics of multiple sclerosis. Curr. Opin. Neurol. 10:1997;181-185.
14. Pang H., Miranda K., Fine A. Sp3 regulates fas expression in lung epithelial cells. Biochem. J. 333:1998;209-213.
15. Sambrook J., Fritsch E.F., Maniatis T., 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed Cold Spring Harbor Laboratory, Cold Spring Harbor.