Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice

Journal of Immunology

Volumn 165, Issue 1, 2000, Pages 518-527

  Wagar, Eric J ^a   Cromwell, Mandy A ^a   Shultz, Leonard D ^b   Woda, Bruce A ^a   Sullivan, John L ^a   Hesselton, RuthAnn M ^a   Greiner, Dale L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL TRANSFER; EPSTEIN BARR VIRUS; GENE MUTATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOPROLIFERATIVE DISEASE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; VIRUS INFECTION;

EID: 0034234591     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.1.518     Document Type: Article

References (60)

1. Mosier, D. E., R. J. Gulizia, S. M. Baird, and D. B. Wilson. 1988. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256.
2. + T cell repertoire in hu-PBL-SCID chimeras. J. Exp. Med. 180:1817.
3. Greiner, D. L., and L. D. Shultz. 1998. Use of NOD/LtSz-scid/scid mice in biomedical research. In NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer and Other Diseases. E. H. Leiter and M. A. Atkinson, eds. R.G. Landes Co., Austin, pp. 173-203.
4. Hesselton, R. M., R. A. Koup, M. A. Cromwell, B. S. Graham, M. Johns, and J. L. Sullivan. 1993. Human peripheral blood xenografts in the SCID mouse: characterization of immunologic reconstitution. J. Infect. Dis. 168:630.
5. Sullivan, J. L. 1988. Epstein-Barr virus and lymphoproliferative disorders. Semin. Hematol. 25:269.
6. Rowe, M., L. S. Young, J. Crocker, H. Stokes, S. Henderson, and A. B. Rickinson. 1991. Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man. J. Exp. Med. 173:147.
7. Groopman, J. E., J. L. Sullivan, C. Mulder, D. Ginsburg, S. H. Orkin, C. J. O'Hara, K. Falchuk, F. Wong-Staal, and R. C. Gallo. 1986. Pathogenesis of B cell lymphoma in a patient with AIDS. Blood 67:612.
8. Saemundsen, A. K., D. T. Purtilo, K. Sakamoto, J. L. Sullivan, A. C. Synnerholm, D. Hanto, R. Simmons, Anvret, R. Collins, and G. Klein. 1981. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridization. Cancer Res. 41:4237.
9. Purtilo, D. T., K. Sakamoto, A. K. Saemundsen, J. L. Sullivan, A. C. Synnerholm, M. Anvret, J. Pritchard, C. Sloper, C. Sieff, J. Pincott, et al. 1981. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological, and immunopathological studies. Cancer Res. 41:4226.
10. Penn, I. 1981. Malignant lymphomas in organ transplant recipients. Transplant. Proc. 13:736.
11. Mosier, D. E., G. R. Picchio, M. B. Kirven, J. L. Garnier, B. E. Torbett, S. M. Baird, R. Kobayashi, and T. J. Kipps. 1992. EBV-induced human B cell lymphomas in hu-PBL-SCID mice. AIDS Res. Hum. Retroviruses 8:735.
12. Pisa, P., M. J. Cannon, E. K. Pisa, N. R. Cooper, and R. I. Fox. 1992. Epstein-Barr virus induced lymphoproliferative tumors in severe combined immunodeficient mice are oligoclonal. Blood 79:173.
13. Cannon, M. J., P. Pisa, R. I. Fox, and N. R. Cooper. 1990. Epstein-Barr virus induces aggressive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice. J. Clin. Invest. 85:1333.
14. Rickinson, A. B., and D. I. Moss. 1997. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu. Rev. Immunol 15:405.
15. Seeley, J., E. Svedmyr, O. Weiland, G. Klein, E. Moller, E. Eriksson, K. Andersson, and L. van der Waal. 1981. Epstein Barr virus selective T cells in infectious mononucleosis are not restricted to HLA-A and B antigens. J. Immunol. 127:293.
16. Galili, U., J. Seeley, E. Svedmyr, E. Klein, G. Klein, and O. Weiland. 1980. Blood lymphocytes in infectious mononucleosis share the following characteristics with activated T cells: natural attachment, stable E rosetting and glucocorticoid sensitivity. J. Clin. Lab. Immunol. 3:153.
17. Greiner, D. L., L. D. Shultz, J. Yates, M. C. Appel, G. Perdrizet, R. M. Hesselton, I. Schweitzer, W. G. Beamer, K. L. Shultz, S. C. Pelsue, et al. 1995. Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am. J. Pathol. 146:888.
18. Hesselton, R. M., D. L. Greiner, J. P. Mordes, T. V. Rajan, J. L. Sullivan, and L. D. Shultz. 1995. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J. Infect. Dis. 172:974.
19. Shultz, L. D., P. A. Schweitzer, S. W. Christianson, B. Gott, I. B. Schweitzer, S. McKenna, L. Mobraaten, T. V. Rajan, D. L. Greiner, and E. H. Leiter. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol 154:180.
20. 2-microglobulin-deficient NOD-scid mice. J. Immunol. 158:3578.
21. Tanaka, T., M. Tsudo, H. Karasuyama, F. Kitamura, T. Kono, M. Hatakeyama, T. Taniguchi, and M. Miyasaka. 1991. A novel monoclonal antibody against murine IL-2 receptor β-chain: characterization of receptor expression in normal lymphoid cells and EL-4 cells. J. Immunol. 147:2222.
22. Nilsson, K. 1971. High-frequency establishment of human immunoglobulin-producing lymphoblastoid lines from normal and malignant lymphoid tissue and peripheral blood. Int. J. Cancer 8:432.
23. Wunderlich, J., and G. Shearer. 2000. Induction and measurement of cytotoxic T lymphocyte activity. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, p. 3.11.1.
24. Whalen, B. J., L. C. Love, J. P. Mordes, A. A. Rossini, and D. L. Greiner. 1999. Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes. Transplant. Proc. 31:1611.
25. Kaplan, E. L., and P. Meier. 1958. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457.
26. Nie, N. H., C. H. Hull, J. G. Jenkins, K. Steinbrenner, and D. H. Bent. 1975. Statistical Package for the Social Sciences. McGraw-Hill, New York, p. 1.
27. Glantz, S. A. 1981. Primer of Biostatistics. McGraw-Hill. New York, p. 352.
28. Tary-Lehmann, M., and A. Saxon. 1992. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J. Exp. Med. 175:503.
29. Tary-Lehmann, M., A. Saxon, and P. V. Lehmann. 1995. The human immune system in hu-PBL-SCID mice. Immunol. Today 16:529.
30. Hesselton, R. M., D. L. Greiner, J. P. Mordes, T. V. Rajan, J. L. Sullivan, and L. D. Shultz. 1995. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J. Infect. Dis 172:974.
31. Song, H. K., H. A. Noorchashm, Y. K. Lieu, S. Rostami, S. A. S. Greeley, C. F. Barker, and A. Naji. 1999. Cutting edge: alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 costimulation. J. Immunol. 162:2467.
32. Ehl, S., R. Nuesch, T. Tanaka, M. Myasaka, H. Hengartner, and R. Zinkernagel. 1996. A comparison of efficacy and specificity of three NK depleting antibodies. J. Immunol. Methods 199:149.
33. Foy, T. M., M. McIlraith, S. R. Masters, J. J. Dunn, A. A. Rossini, L. D. Shultz, R. A. Hesselton, E. J. Wagar, P. E. Lipsky, R J. Noelle, et al. 1998. Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice. Cell Transplant. 7:25.
34. Torbett, B. E., G. Picchio, and D. E. Mosier. 1991. HuPBL/SCID mice: a model for human immune function, AIDS, and lymphomagenesis. Immunol. Rev. 124: 139.
35. Christianson, S. W., D. L. Greiner, I. B. Schweitzer, B. Gott, G. L. Beamer, P. A. Schweitzer, R. M. Hesselton, and L. D Shultz. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell. Immunol. 171:186.
36. Tournoy, K. G., S. Depraetere, P. Meuleman, B. Leroux-Roels, and R. A. Pauwels. 1998. Murine IL-2 receptor β chain blockade improves human leukocyte engraftment in SCID mice. Ear. J. Immunol. 28:3221.
37. Waldrnann, T. A. 1989. The multi-subunit interleukin-2 receptor. Annu. Rev. Biochem. 58:875.
38. Waldmann, T. A. 1991. The interleukin-2 receptor. J. Biol. Chem. 266:2681.
39. Markham, R. B., D. H. Schwartz, A. Templeton, J. B. Margolick, H. Farzadegan, D. Vlahov, and X. F. Yu. 1996. Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells. J. Virol 70:6947.
40. + T cells requires CD154 expression by Th cells in acute graft versus host disease. J. Immunol. 162:4373.
41. + T cells, IL-2, and NK cell-derived TGF-β: contrasting effects of anti-CD2 and anti-CD3. J. Immunol. 160:2248.
42. - T cells. Int. Immunol. 10:775.
43. Miller, A., O. Lider, and H. L. Weiner. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174 :791.
44. - regulatory T cells. J. Immunol. 161:5193.
45. Frasca, L., P. Carmichael, R. Lechler, and G. Lombardi. 1997. Anergic T cells effect linked suppression. Eur. J. Immunol. 27:3191.
46. Lombardi, G., S. Sidhu, R. Batchelor, and R. Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264:1587.
47. Boyle, T. J., K. R. Berend, J. M. DiMaio, R. E. Coles, D. F. Via, and H. K. Lyerly. 1993. Adoptive transfer of cytotoxic T lymphocytes for the treatment of transplant-associated lymphoma. Surgery 114:218.
48. + cytotoxic T cells against Epstein-Barr virus-immortalized B cell tumors in SCID mice. Transplantation 58:629.
49. Buchsbaum, R. J., J. A. Fabry, and J. Lieberman. 1996. EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice. Immunol. Lett. 52:145.
50. Rooney, C. M., C. A. Smith, C. Y. Ng, S. K. Loftin, J. W. Sixbey, Y. Gan, D. K. Srivastava, L. C. Bowman, R. A. Krance, M. K. Brenner, et al. 1998. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92:1549.
51. Heslop, H. E., C. Y. Ng, C. Li, C. A. Smith, S. K. Loftin, R. A. Krance, M. K. Brenner, and C. M. Rooney. 1996. Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat. Med. 2:551.
52. Gustafsson, A., V. Levitsky, J. Z. Zou, T. Firsan, T. Dalianis, P. Ljungman, O. Ringden, J. Winiarski, I. Ernberg, and M. G. Masucci. 2000. Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop post-transplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells. Blood 95:807.
53. Khanna, R., S. Bell, M. Sherritt, A. Galbraith, S. R. Burrows, L. Rafter, B. Clarke, R. Slaughter, M. C. Falk, J. Douglass, et al. 1999. Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proc. Natl. Acad. Sci. USA 96:10391.
54. Lacerda, J. F., M. Ladanyi, D. C. Louie, J. M. Fernandez, E. B. Papadopoulos, and R. J. O'Reilly. 1996. Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B.-17 Scid/Scid mice. J. Exp. Med. 183:1215.
55. Nalesnik, M. A., A. S. Rao, H. Furukawa, S. Pham, A. Zeevi, J. J. Fung, G. Klein, H. A. Gritsch, E. Elder, T. L. Whiteside, et al. 1997. Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients. Transplantation 63: 1200.
56. Lucas, P. J., C. V. Bare, and R. E. Gress. 1995. The human anti-murine xenogeneic cytotoxic response. II. Activated murine antigen-presenting cells directly stimulate human T helper cells. J. Immunol. 154:3761.
57. Lucas, P. J., G. M. Shearer, S. Neudorf, and R. E. Gress. 1990. The human antimurine xenogeneic cytotoxic response. I. Dependence on responder antigen-presenting cells. J. Immunol. 144:4548.
58. Taams, L. S., W. van Eden, and M. H. Wauben. 1999. Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions. Eur. J. Immunol. 29:1543.
59. Pichler, W. J., and T. Wyss-Coray. 1994. T cells as antigen-presenting cells. Immunol. Today 15:312.
60. Garcia, S., G. Dadaglio, and M. L. Gougeon. 1997. Limits of the human-PBL-SCID mice model: severe restriction of the Vβ T-cell repertoire of engrafted human T cells. Blood 89:329.