A stochastic model of chromosome segregation errors with reference to cancer cells

Mathematical and Computer Modelling

Volumn 32, Issue 1-2, 2000, Pages 97-111

  Gusev, Y ^a,c   Kagansky, V ^b   Dooley, W C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Molecular Staging Inc   (United States)

Author keywords

Cancer; Chromosomal instability; Chromosomes; Random branching walk; Stochastic models

Indexed keywords

CANCER CELL; CELL DEATH; CELL DIVISION; CELL SURVIVAL; CHROMOSOME NUMBER; CHROMOSOME SEGREGATION; CHROMOSOME WALKING; COMPUTER SIMULATION; DIPLOIDY; GENETIC MODEL; HUMAN CELL; KARYOTYPE; SEGREGATION ERROR;

EID: 0034234174     PISSN: 08957177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7177(00)00122-9     Document Type: Article

References (16)

1. C. Lengauer, K.W, Kinzler and B. Vogelstein, DNA methylation and genetic instability in colorectal cancer cells, Proc. NaÜ. Acad. Sci. USA 94, 2545-2550 (1997).
2. K. Fukasawa, T. Choi, R. Kuriyama, S. Rulong and G.F. Vande Woulde, Abnormal centrosome amplification in the absence of p53, Science 271, 1744-1747 (1996).
3. C. Lengauer, K.W. Kinzler and B. Vogelstein, Genetic instability in colorectal cancers, Nature 386, 623-627 (1997).
4. P. Devilee, R.F. Thierry, T. Kievits, R. Kolluri, A.H.N. Hopman, H.F. Willard, P.L. Pearson and C.J. Cornelisse, Detection of chromosome aneuploidy in interphase nuclei from human primary breast tumors using chromosome-specific repetitive DNA probes, Cancer Research 48, 5825-5829 (1988).
5. H. Van Dekken, J.G. Pizzolo, V.E. Reuter and M.R. Melamed, Cytogenetic analysis of human solid tumors by in situ hybridization with a set of 12 chromosome-specific DNA probes, Oytogenet Cell Genet. 54, 103-107 (1990).
6. P.M. Waldman, P.R. Carroll, R. Kerschmann, M.B. Cohen, F.G. Field and B.H. Mayall, Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer, Cancer Research 51, 3807-3812 (1991).
7. R. Tollennaar, B. Bonsing, N. Kuipers-Dijkshoorn, J. Hermans, C. van de Velde, C. Cornelisse and G. Fleuren, Evidence of clonal divergence in colorectal carcinoma, Cancer 79 (7), 1304-1314 (1997).
8. S.E. Shackney, C.A. Smith, B.W. Miller, D.R. Burholt, K. Murtha, H.R. Giles, D.M. Ketterer and A.A. Pollice, Model of the genetic evolution of human solid tumors, Cancer Research 49, 3344-3354 (1989).
9. M. Kimmel and D.N. Stivers, Time-continuous branching walk models of unstable gene amplification, Bulletin of Mathematical Biology 56 (2), 337-357 (1994).
10. A.A. Sandberg, The Chromosomes in Human Cancer and Leukemia, North-Holland, New York, (1980).
11. M. Yanagida, Frontier questions about sister chromatid separation in anaphase, BioEssays 17 (6), 519-526 (1995).
12. P.C. Nowell, Mechanisms of tumor progression, Cancer Research 46, 2203-2207 (1986).
13. P. Cader, A. Wyllie, C. Purdie, R.G. Morris, S. White, J. Piris and C. Bird, Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer, Oncogene 8, 1397-1408 (1993).
14. K.H. Walen and P. Arnstein, Induction of tumorigenesis and chromosomal abnormalities in human amniocytes infected with simian virus 40 and Kirsten sarcoma virus, In Vitro Cellular & Developmental Biology-Animal. 22, 57-67 (1986).
15. F.A. Ray, J. Meyne and P.M. Kraemer, SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing throughout neoplastic progression of human fibroblasts, Mutation Research 284, 265-273 (1992).
16. Y. Gusev et ai, Modeling of chromosomal instability in colorectal cancer cells, TBA (1997).