Central administration of an antisense oligodeoxynucleotide against type I pituitary adenylate cyclase-activating polypeptide receptor suppresses synthetic activities of LHRH-LH axis during the pubertal process

Molecular Brain Research

Volumn 80, Issue 1, 2000, Pages 35-45

  Choi, Eun Jung ^a   Ha, Chang Man ^a   Kim, Min Sung ^a   Kang, Ji Hyun ^a   Park, Sang Kyu ^a   Choi, Wan Sung ^b   Kang, Sung Goo ^c   Lee, Byung Ju ^a  

^a University of Ulsan   (South Korea)

^b Gyeongsang National University   (South Korea)

^c Inje University   (South Korea)

Author keywords

Antisense PAC1 oligodeoxynucleotide; Female puberty; LHRH; PACAP; PACAP receptor type I (PAC1)

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GONADORELIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; LUTEINIZING HORMONE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; NONHUMAN; PRIORITY JOURNAL; PUBERTY; RAT;

ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; LUTEINIZING HORMONE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OVULATION; PITUITARY GLAND; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I; RECEPTORS, PITUITARY HORMONE; SEXUAL MATURATION;

ANIMALIA;

EID: 0034233625     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00116-9     Document Type: Article

References (59)

1. Amico J.A., Thomas A., Hollingshead D.J. The duration of estradiol and progesterone exposure prior to progesterone withdrawal regulates oxytocin mRNA levels in the paraventricular nucleus of the rat. Endocr. Res. 23:1997;141-156.
2. Andrews W.W., Advis J.P., Ojeda S.R. The first proestrus in the female rat: circulating steroid levels preceding and accompanying the preovulatory LH surge. Proc. Soc. Exp. Biol. Med. 163:1980;305-309.
3. Arimura A., Shioda S. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction. Front. Neuroendocrinol. 16:1995;53-58.
4. Bauer-Dantoin A.C., Hollenberg A.N., Jameson J.L. Dynamic regulation of gonadotropin-releasing hormone receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle. Endocrinology. 133:1993;1911-1914.
5. Braas K.M., May V. Pituitary adenylate cyclase-activating polypeptides directly stimulates sympathetic neuron neuropeptide Y release through PAC1 receptor isoform activation of specific intracellular signalling pathways. J. Biol. Chem. 274:1999;27702-27710.
6. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
7. Correa-Rotter R., Mariash C.N., Rosenberg M.E. Loading and transfer contol for Northern hybridization. Bio. Techniques. 12:1992;154-158.
8. Culler M.D., Paschall C.S. Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates the gonadotropin-releasing activity of luteinizing hormone-releasing hormone. Endocrinology. 129:1991;2260-2262.
9. Danielson P.E., Forss-Petter S., Brow M.A., Calavetta L., Douglass J., Milner R.J., Sutcliffe J.G. p1B15: A cDNA clone of the rat mRNA encoding cyclophilin. DNA. 7:1988;261-267.
10. Dautzenberg F.M., Mevenkamp G., Wille S., Hauger R.L. N-terminal splice variants of the type I PACAP receptor: isolation, charaterization and ligand binding/selectivity determinants. J. Neuroendocrinol. 11:1999;941-949.
11. Gay V.L., Plant T.M. N-methyl-D,L-asparatate (NMA) elicits hypothalamic GnRH release in prepubertal male rhesus monkeys (Macaca mulatta). Endocrinology. 120:1987;2289-2296.
12. Goldsmith P.C., Song T. The gonadotropin-releasing hormone containing ventral hypothalamic tract in the fetal rhesus monkey (Macaca mulatta). J. Comp. Neurol. 237:1987;130-149.
13. Gore A.C., Terasawa E. A role for norepinephrine in the control of puberty in the female rhesus monkey, Macaca mulatta. Endocrinology. 129:1991;3009-3017.
14. Gore A.C., Wu T.J., Rosenberg J.J., Roberts J.L. Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats. J. Neurosci. 16:1996;5281-5289.
15. 1) in the rat hypothalamus. Mol. Brain Res. 78:2000;59-68.
16. Inagaki N., Yoshida H., Mizuta M., Mizuno N., Fujii Y., Gonoi T., Miyazaki J., Seino S. Cloning and functional characterization of a third pituitary adenylae cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc. Natl. Acad. Sci. USA. 91:1994;2679-2683.
17. Ishihara T., Shigemoto R., Mori K., Takahashi K., Nagata S. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 8:1992;811-819.
18. Jennes L., McShane T., Brame B., Centers A. Dynamic changes in gonadotropin releasing hormone receptor mRNA content in the mediobasal hypothalamus during the rat estrous cycle. J. Neuroendocrinol. 8:1996;275-281.
19. Journot L., Waeber C., Pantaloni C., Holsboer F., Seeburg P.H., Bockaert J., Spengler D. Differential signal transduction by six splice variants of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor. Biochem. Soc. Trans. 23:1995;133-137.
20. Kaiser U.B., Sabbagh E., Katzenellenbogen R.A., Conn P.M., Chin W.W. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proc. Natl. Acad. Sci. USA. 92:1995;12280-12284.
21. Kakar S.S., Grantham K., Musgrove L.C., Devor D., Sellers J.C., Neill J.D. Rat gonadotropin-releasing hormone (GnRH) receptor: tissue expression and hormonal regulation of its mRNA. Mol. Cell. Endocrinol. 101:1994;151-157.
22. Kim K., Lee B.J., Park Y., Cho W.K. Progesterone increases messenger ribonucleic acid (mRNA) encoding luteinizing hormone releasing hormone (LHRH) level in the hypothalamus of ovariectomized estradiol-primed prepubertal rats. Mol. Brain Res. 6:1989;151-158.
23. Köves K., Arimura A., Gorcs T.G., Somogyvari-Vigh A. Comparative distrubution of immunoreactive pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in rat forebrain. Neuroendocrinology. 54:1991;159-169.
24. Köves K., Molnar J., Kantor O., Lakatos A., Fogel K., Kausz M., Vandermeers-Piret C., Somogyvari-Vigh A., Arimura A. Role of PACAP in the regulation of gonadotropin hormone secretion during ontogenesis: a single neonatal injection of PACAP delays puberty and its intracerebroventricular administration before the critical period of proestrous stage blocks ovulation in adulthood. Ann. NY Acad. Sci. 865:1998;590-594.
25. Landgraf R. Antisense targeting in behavioural neuroendocrinology. J. Endocrinol. 151:1996;333-340.
26. Leung K., Kim K.E., Maurer R.A., Landefeld T.D. Divergent changes in the concentrations of ganadotropin beta-subunit messenger ribonucleic acid during the estrous cycle of sheep. Mol. Endocrinol. 2:1988;272-276.
27. Li S., Grinevich V., Fournier A., Pelletier G. Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on gonadotropin-releasing hormone and somatostain gene expression in the rat brain. Mol. Brain Res. 41:1996;157-162.
28. Ma Y.J., Dissen G.A., Rage F., Ojeda S.R. RNase protection assay. Methods. 10:1996;273-278.
29. Ma Y.J., Junier M.-P., Costa M.E., Ojeda S.R. Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron. 9:1992;657-670.
30. Minami S., Frautschy S.A., Plotsky P.M., Sutton S.W., Sarkar D.K. Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing hormone-releasing hormone. Neuroendocrinology. 52:1990;112-115.
31. Mitsushima D., Hei D.L., Terasawa E. Gamma-aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc. Natl. Acad. Sci. USA. 91:1994;395-399.
32. Nicot A., Pfaff D.W. Antisense oligodeoxynucleotides as specific tools for studying neuroendocrine and behavioral functions: some prospects and problems. J. Neurosci. Methods. 71:1997;45-53.
33. Ojeda S.R., Urbanski H.F. Puberty in the rat. Knobil E., Neill J.D. The Physiology of Reproduction. Vol. 2:1994;363-409 Raven, New York.
34. Ojeda S.R., Urbanski H.F., Ahmed C.E. The onset of female puberty: studies in the rat. Recent. Prog. Horm. Res. 42:1986;385-442.
35. Olcese J., McArdle C.A., Middendorff R., Greenland K. Pituitary adenylate cyclase-activating peptide and vasoactive intestinal peptide receptor expression in immortalized LHRH neuron. J. Neuroendocrinol. 9:1997;937-943.
36. Pantaloni C., Brabet P., Bilanges B., Dumuis A., Houssami S., Spengler D., Bockaert J., Journot L. Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. J. Biol. Chem. 271:1996;22146-22151.
37. Pisegna J.R., Wank S.A. Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor. Proc. Natl. Acad. Sci. USA. 90:1993;6345-6349.
38. Quinones-Jenab V., Jenab S., Ogawa S., Funabashi T., Weesner G.D., Pfaff D.W. Estrogen regulation of gonadotropin-releasing hormone receptor messenger RNA in female rat pituitary tissue. Mol. Brain Res. 38:1996;243-250.
39. Ramirez V.D., Dluzen D., Lin D. Progesterone administration in vivo stimulates release of luteinizing hormone-releasing hormone in vitro. Science. 208:1980;1037-1039.
40. Raum W.J., Glass A.R., Swerdloff R.S. Changes in hypothalamic catecholamine neurotransmitters and pituitary gonadotropins in the immature female rat: relationships to the gonadostat theory of puberty onset. Endocrinology. 106:1980;1253-1258.
41. Rawlings S.R., Hezareh M. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/vasoactive intestinal polypeptide receptors: actions on the anterior pituitary gland. Endocr. Rev. 17:1996;4-29.
42. Ringstrom S.J., Szabo M., Kilen S.M., Saberi S., Knox K.L., Schwartz N.B. The antiprogestins RU486 and ZK98299 affect follicle-stimulating hormone secretion differentially on estrus, but not proestrus. Endocrinology. 138:1997;2286-2290.
43. Risau W. Molecular biology of blood-brain barrier ontogenesis and function. Acta. Neurochir. Suppl. 60:1994;109-112.
44. Rogers L.C., Junier M.-P., Farmer S.R., Ojeda S.R. A sex-related difference in the developmental expression of class II β-tubulin messenger RNA in rat hypothalamus. Mol. Cell. Neurosci. 2:1991;130-138.
45. Schomerus E., Poch A., Bunting R., Mason W.T., McArdle C.A. Effects of pituitary adenylate cyclase-activating polypeptide in the pituitary: activation of two signal transduction pathways in the gonadotrope-derived alpha T3-1 cell line. Endocrinology. 134:1994;315-323.
46. Senjo M., Ishibashi T., Terashima T., Inoue Y. Correlation between astrogliogenesis and blood-brain barrier formation: immunocytochemical demonstration by using astroglia-specific enzyme glutathion S-transferase. Neurosci. Lett. 66:1986;39-42.
47. Shuto Y., Somogyvari-Vigh A., Onda H., Arimura A. Effect of hypophysecomy on pituitary adenylate cyclase activating polypeptide gene expression in the rat hypothalamus. Peptides. 16:1995;407-413.
48. Silverman A.-J., Antunes J.L., Abrams G.M., Nilaver G., Thau R., Robinson J.A., Ferin M., Krey L.C. The luteinizing hormone-releasing hormone pathways in rhesus (Macaca mulatta) and pitailed (Macaca nemestrina) monkeys: new observations on thick, unembedded sections. J. Comp. Neurol. 211:1982;309-317.
49. Skutella T., Criswell H., Moy S., Probst J.C., Breese G.R., Jirikowski G.F., Holsboer F. Corticotropin releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat. Neuroreport. 27:1994;2181-2185.
50. Spengler D., Waeber C., Pantaloni C., Holsboer F., Bockaert J., Seeburg P.H., Journot L. Differential signal transduction by five splice variants of the PACAP receptor. Nature. 365:1993;170-175.
51. Sutton S.W., Mitsugi N., Plotsky P.M., Sarkar D.K. Neuropeptide Y (NPY): a possible role in the initiation of puberty. Endocrinology. 123:1988;2152-2154.
52. Terasawa E. Control of luteinizing hormone releasing hormone pulse generation in nonhuman primates. Cell. Mol. Neurobiol. 15:1995;141-164.
53. Tsujii T., Ishizaka K., Winters S.J. Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acids in perifused rat pituitary cells. Endocrinology. 135:1994;826-833.
54. Urbanski H.F., Ojeda S.R. A role of N-methyl-D-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty. Endocrinology. 126:1990;1774-1776.
55. Wahlestedt C. Antisense oligonucleotides strategies in neuropharmacology. Trends Pharmacol. Sci. 15:1994;42-46.
56. Wahlestedt C., Golanov E., Yamamoto S., Yee F., Ericson H., Yoo H., Inturrisi C.E., Reis D.J. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarction. Nature. 363:1993;260-263.
57. Winkler A., Roske I., Furkert J., Fickel J., Melzig M.F. Effects of voluntary ethanol ingestion on the POMC gene expression in the rat pituitary and on the plasma beta-endorphin content. Alcohol Alcohol. 30:1995;231-238.
58. Zhou L.W., Zhang S.P., Qin Z.H., Weiss B. In vivo administration of an oligonucleotide antisense to the D2 dopamine receptor messenger RNA inhibits D2 dompamine receptor-mediated behavior and the expression of D2 dopamine receptors in mouse striatum. J. Pharmacol. Exp. Ther. 268:1994;1015-1023.
59. Zmeili S.M., Papavasiliou S.S., Thorner M.O., Evans W.S., Marshall J.C., Landefeld T.D. Alpha and luteinizing hormone beta subunit messenger ribonucleic acids during the rat estrous cycle. Endocrinology. 119:1986;1867-1869.