The antiprogestins RU486 and ZK98299 affect follicle-stimulating hormone secretion differentially on estrus, but not on proestrus

Endocrinology

Volumn 138, Issue 6, 1997, Pages 2286-2290

  Ringstrom, Sonia J ^a   Szabo, Marta ^a   Kilen, Signe M ^a   Saberi, Sara ^a   Knox, Kerry L ^a,b   Schwartz, Neena B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; MIFEPRISTONE; ONAPRISTONE; PROGESTERONE RECEPTOR;

ARTICLE; DOSE RESPONSE; ESTRUS CYCLE; FEMALE; FOLLITROPIN RELEASE; GONADOTROPIN BLOOD LEVEL; HORMONE ACTION; HORMONE INHIBITION; LUTEINIZING HORMONE BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; PROESTRUS; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSCRIPTION REGULATION; UTERUS FLUID;

EID: 0030975068     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.6.5161     Document Type: Article

References (37)

1. Schwartz NB 1995 Follicle stimulating hormone and luteinizing hormone: a tale of two gonadotropins. Can J Physiol Pharmacol 73:675-684
2. A dimer) and total α inhibin in the peripheral circulation and ovaries of rats after gonadotrophin-induced follicular development and during the normal oestrus cycle. J Endocrinol 147:271-283
3. Woodruff TK, Besecke LM, Groome N, Draper LB, Schwartz NB, Weiss J 1996 Inhibin A and inhibin B are inversely correlated to FSH yet are discordant during the follicular phase of the rat estrous cycle and inhibin A is expressed in a sexually dimorphic manner. Endocrinology 137:5463-5467
4. Knox KL, Schwartz NB 1992 RU486 blocks the secondary surge of follicle-stimulating hormone in the rat without blocking the drop in serum inhibin. Biol Reprod 46:220-225
5. Knox KL, Ringstrom SJ, Schwartz NB 1993 RU486 blocks the effects of inhibin antiserum or luteinizing hormone on the secondary follicle-stimulating hormone surge. Endocrinology 133:277-283
6. Szabo M, Knox KL, Ringstrom SJ, Perlyn CA, Sutandi S, Schwartz NB 1996 Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge. Endocrinology 137:1226-1232
7. Rivier C, Vale W 1989 Immunoneutralization of endogenous inhibin modifies hormone secretion and ovulation rate in the rat. Endocrinology 125:152-157
8. Arai K, Watanabe G, Taya K, Sasamoto S 1996 Roles of inhibin and estradiol in the regulation of follicle-stimulating hormone and luteinizing hormone secretion during the estrous cycle of the rat. Biol Reprod 55:127-133
9. Knox KL, Ringstrom SJ, Szabo M, Perlyn CA, Sutandi S, Schwartz NB 1996 RU486 on an estrogen background blocks the rise in serum follicle-stimulating hormone induced by antiserum to inhibin or ovariectomy. Endocrinology 137:1226-1232
10. Horwitz K 1992 The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev 13:146-163
11. Aloi JA, Dalkin AC, Schwartz NB, Yasin M, Mann B, Haisenleder DJ, Marshall JC 1995 Ovarian inhibin subunit gene expression: regulation by gonadotropins and estradiol. Endocrinology 136:1227-1232
12. Ackland JF, D'Agostino J, Ringstrom SJ, Hostetler JP, Mann BG, Schwartz NB 1990 Circulating radioimmunoassayable inhibin during periods of transient follicle-stimulating hormone rise: secondary surge and unilateral ovariectomy. Biol Reprod 43:347-352
13. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
14. Kilen SM, Szabo M, Strasser GA, McAndrews JM, Ringstrom SJ, Schwartz NB 1996 Corticosterone selectively increases FSHβ subunit mRNA in primary anterior pituitary cell culture without affecting its half-life. Endocrinology 137:3802-3807
15. Klein-Hitpass L, Cato ACB, Henderson D, Ryffel GU 1991 Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells. Nucleic Acids Res 19:1227-1234
16. Sartorius CA, Tung L, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem 268:9262-9266
17. Delabre K, Guiochon-Mantel A, Milgrom E 1993 In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA. Proc Natl Acad Sci USA 90:4421-4425
18. Truss M, Bartsch J, Beato M 1994 Antiprogestins prevent progesterone receptor binding to hormone responsive elements in vivo. Proc Natl Acad Sci USA 91:11333-11337
19. Elger W, Beier S, Chwalisz K, Fanrich M, Hasan SH, Henderson D, Neef G, Rohde R 1986 Studies on the mechanisms of action of progesterone antagonists. J Steroid Biochem 25:835-845
20. Baulieu E-E 1991 The antisteroid RU486: its cellular and molecular mode of action. Trends Endocrinol Metab 2:233-239
21. Nordeen SK, Bona BJ, Moyer ML 1993 Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A. Mol Endocrinol 7:731-742
22. Beck CA, Weigel NL, Moyer ML, Nordeen SK, Edwards DP 1993 The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways. Proc Natl Acad Sci USA 90:4441-4445
23. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7:1256-1265
24. McDonnell DP, Goldman ME 1994 RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. J Biol Chem 269:11945-11949
25. Beck CA, Zhang Y, Weigel NL, Edwards DP 1996 Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor. J Biol Chem 271:1209-1217
26. McAndrews JM, Ringstrom SJ, Dahl KD, Schwartz NB 1994 Corticosterone in vivo increases pituitary follicle-stimulating hormone (FSH)-β messenger ribonucleic acid content and serum FSH bioactivity selectively in female rats. Endocrinology 134:158-163
27. Suter DE, Schwartz NB 1985 Effects of glucocorticoids on secretion of luteinizing hormone and follicle-stimulating hormone by female rat pituitary cells in vitro. Endocrinology 117:849-854
28. Tébar M, Bellido C, Sánchez-Criado JE 1995 Luteinizing hormone (LH) and corticosterone in proestrous afternoon restore the follicle-stimulating hormone secretion at early estrus in adrenalectomized LH-releasing hormone antagonist-treated rats. Biol Reprod 52:63-67
29. Uilenbroek JTJ 1991 Hormone concentrations and ovulatory response in rats treated with antiprogestagens. J Endocrinol 129:423-429
30. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP 1993 Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7:1244-1255
31. Kazmi SM, Visconti V, Plante RK, Ishaque A, Lau C 1993 Differential regulation of progesterone receptor A and B form-mediated trans-activation by phosphorylation. Endocrinology 133:1230-1238
32. Oñate SA, Tsai SY, Tsai M-J, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357
33. Chen JD, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
34. Katzenellenbogen JA, O'Malley BW, Katzenellenbogen BS 1996 Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for cell- and promoter-specific action of these hormones. Mol Endocrinol 10:119-131
35. Horwitz KB, Jackson TA, Bain TL, Richer JK, Takimoto GS, Tung L 1996 Nuclear receptor coactivators and corepressors. Mol Endocrinol 10:1167-1177
36. Romano GJ, Krust A, Pfaff DW 1989 Expression and estrogen regulation of progesterone receptor mRNA in neurons of the mediobasal hypothalamus: an in situ hybridization study. Mol Endocrinol 3:1295-1300
37. Bethea CL, Brown NA, Kohama SG 1996 Steroid regulation of estrogen and progestin receptor messenger ribonucleic acid in monkey hypothalamus and pituitary. Endocrinology 137:4372-4383