Acute thromboscintigraphy with 99mTc-apcitide: Results of the phase 3 multicenter clinical trial comparing 99mTc- apcitide scintigraphy with contrast venography for imaging acute DVT

Journal of Nuclear Medicine

Volumn 41, Issue 7, 2000, Pages 1214-1223

  Taillefer, Raymond ^a   Edell, Stephen ^b   Innes, Grant ^b   Lister James, John ^b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NONE

Author keywords

99mTc apcitide; Acute deep venous thrombosis; Scintigraphy; Venography

Indexed keywords

APCITIDE TC 99M; CONTRAST MEDIUM; FIBRINOGEN RECEPTOR; HEPARIN; MOLYBDENUM 99; PERTECHNETIC ACID TC 99M; UNCLASSIFIED DRUG; CYCLOPEPTIDE; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M P280;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTRAST ENHANCEMENT; DEEP VEIN THROMBOSIS; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HYPESTHESIA; HYPOTENSION; INTERMETHOD COMPARISON; ISOTOPE LABELING; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PHASE 3 CLINICAL TRIAL; PHLEBOGRAPHY; PRIORITY JOURNAL; RASH; SCINTIGRAPHY; SYNCOPE; THROMBOCYTE ACTIVATION; VOMITING; ACUTE DISEASE; COMPARATIVE STUDY; LEG; MIDDLE AGED; PROSPECTIVE STUDY; RADIOGRAPHY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; VASCULARIZATION; VEIN THROMBOSIS;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; CONTRAST MEDIA; FEMALE; HUMANS; LEG; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; PEPTIDES, CYCLIC; PHLEBOGRAPHY; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; VENOUS THROMBOSIS;

EID: 0034222957     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Hirsh J, Hoak J. Management of deep vein thrombosis and pulmonary embolism. Circulation. 1996;93:2212-2245.
2. Moser KM. Venous thromboembolism. Am Rev Respir Dis. 1990;141:235-249.
3. Dalen JE, Alpert JS. Natural history of pulmonary embolism. Prog Cardiovasc Dis. 1975;17:259-270.
4. Kaunitz AM, Hughes JM, Grimes DA, Smith JC, Rochat RW, Kafrissen ME. Causes of maternal mortality in the United States. Obstet Gynecol. 1985;65:605-612.
5. Hull RD, Hirsh J, Carter CJ, et al. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med. 1983;98:891-899.
6. Strandness DE, Langlois Y, Cramer M, Randlett A, Thiele BL. Long-term sequelae of acute venous thrombosis. JAMA. 1983;250:1289-1292.
7. Prandoni P, Lensing AWA, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann intern Med. 1996;125:1-7.
8. Salzman EW, Hirsh J. The epidemiology, pathogenesis, and natural history of venous thrombosis, In: Colman RW, Hirsh J, Marder VJ, Salzman EW, eds. Hemostasis and Thromhosis: Basic Principles and Clinical Practice. 3rd ed. Philadelphia, PA: JB Lippincott; 1993:1275-1296.
9. Raskob GE, Durica SS, George JN. Complications of heparin. In: Hull RD, Raskob GE, Pineo GF, eds. Venous Thromboembolism: An Evidence-Based Atlas. Armonk, NY: Future; 1996:223-239.
10. Hirsh J, Raschke R, Warkentin TE, Dalen JE, Deykin D, Poller L. Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest. 1995;108(suppl):258S-275S.
11. Wells RD, Hirsh J, Anderson DR, et al. Accuracy of clinical assessment of deep-vein thrombosis. Lancet. 1995;345:1326-1330.
12. Stamatakis JD, Kakkar VV, Lawrence D, Bentley PG. The origin of thrombi in the deep veins of the lower limb: a venographic study. Br J Radiol. 1978;65:449-451.
13. Lensing AWA, Hirsh J, Büller HR. Diagnosis of venous thrombosis. In: Coleman RW, Hirsh J, Marder VJ, Salzman EW, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 3rd ed, Philadelphia, PA: JB Lippincott; 1994:1297-1302.
14. Anand SS, Wells PS, Hunt D, Brill-Edwards P, Cook D, Ginsberg JS. Does this patient have deep vein thrombosis? JAMA. 1998;279:1094-1099.
15. Hull RD, Carter CJ, Jay RM, et al. The diagnosis of acute recurrent deep vein thrombosis: a diagnostic challenge. Circulation. 1983;67:901-906.
16. Cronan JJ. Venous thromboembolic disease: the role of US. Radiology, 1993;186: 619-630.
17. Rose SC, Zwiebel WJ, Nelson BD, et al. Symptomatic lower extremity deep venous thrombosis: accuracy, limitations, and role of color duplex flow imaging in diagnosis. Radiology, 1990;175:639-644.
18. Lensing AWA, Doris I, McGrath FP, et al. A comparison of compression ultrasound with color Doppler ultrasound for the diagnosis of symptomless postoperative deep vein thrombosis, Arch Intern Med. 1997;157:765-768.
19. Davidson BL, Elliott CG, Lensing AWA. Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients. Ann Intern Med. 1992;117:735-738.
20. Cronan JJ, Leen V. Recurrent DVT: limitations of US. Radiology. 1989;170:739-742.
21. Screaton NJ, Gillard JH, Berman LH, Kemp PM. Duplicated superficial femoral veins: a source of error in the sonographic investigation of deep vein thrombosis. Radiology. 1998;206:397-401.
22. 99mTc-labeled synthetic peptide P280. J Nucl Med. 1995;36:1384-1391.
23. Lister-James J, Knight LC, Maurer AH, Bush LR, Moyer BR, Dean RT. Thrombus imaging with a technetium-99m-labeled, activated platelet receptor-binding peptide. J Nucl Med. 1996;37:775-781.
24. McLaughlin MSF, Thomson JG, Taylor DW, Kelly ME, Sackett DL. Observer variation in the interpretation of lower limb venograms. AJR. 1979;132:227-229.
25. Hull R, Hirsh J, Sackett DL, et al. Clinical validity of a negative venogram in patients with clinically suspected venous thrombosis. Circulation. 1981;64:622-625.
26. Fleiss JL. Statistical Methods for Rates and Proportions. 2nd ed. New York, NY: J Wiley & Sons: 1981:4-8.
27. Nicolaides AN, Kakkar VV, Field ES, Renney JTG. The origin of deep vein thrombosis: a venographic study. Br J Radiol. 1971;44:653-663.
28. Colman RW, Cook JJ, Niewiarowski S. Mechanisms of platelet aggregation. In: Coleman RW, Hirsh J, Marder VJ, Salzman EW. eds, Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 3rd ed. Philadelphia, PA: JB Lippincott: 1994:508-523.
29. Marguerie GA, Plow EF, Edgington TS. Human platelets possess an inducible and saturable receptor specific for fibrinogen. J Biol Chem. 1979;254:5357-5363.
30. Bauer G. A venographic study of thrombo-embolic problems. Acta Chir Scand. 1940:61(suppl 23):59-64.
31. Freiman DG. The structure of thrombi. In: Coleman R, Hirsh J, Marder V, Salzman EW, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 2nd ed. Philadelphia, PA: JB Lippincott; 1987:1123-1135.
32. Ezekowitz MD, Pope CF, Sostman HD, et at. Indium-III platelet scintigraphy for the diagnosis of acute venous thrombosis. Circulation. 1986;73:668-674.
33. Seabold JE, Conrad GR, Kimball DA, Ponto JA, Bricker JA, Pitfalls in establishing the diagnosis of deep venous thrombophlebitis by indium-III platelet scintigraphy. J Nucl Med. 1988;29:1169-1180.
34. 99mTc-apcitide and correlation with contrast-enhanced venography in detection of acute deep venous thrombosis. J Nucl Med. 1999;40:2029-2035.