HPV-16 E6 oncoprotein induces mutations via p53-dependent and -independent pathways

Oncology Reports

Volumn 7, Issue 4, 2000, Pages 707-712

  Kim, Hyun Jung ^a   Guo, Wentong ^a   Park, No Hee ^a,b  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

HPV E6; Mutation; Oncogenesis; p53

Indexed keywords

E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; ONCOPROTEIN; PROTEIN P53; RECOMBINANT PROTEIN; REPRESSOR PROTEIN;

ARTICLE; CELL CULTURE; COLORECTAL TUMOR; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MUTAGENESIS; PAPILLOMA VIRUS; PATHOGENICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

COLORECTAL NEOPLASMS; HUMANS; MUTAGENESIS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034220886     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.7.4.707     Document Type: Article

References (31)

1. Kuerbitz SJ, Plunkett BS, Walsh WV and Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89: 7491-7495, 1992.
2. Agarwal ML, Agarwal A, Taylor WR and Stark GR: p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 92: 8493-8497, 1995.
3. Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly JM, Wang Z, Freidberg EC, Evans MK and Taffe BG: p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet 10: 188-195, 1995.
4. Sturzbecher HW, Donzelmann B, Henning W, Knippschild U and Buchhop S: p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J 15: 1992-2002, 1996.
5. Lim DS and Hasty P: A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol 16: 7133-7143, 1996.
6. Vousden KH: Human papillomavirus oncoproteins. Semin Cancer Biol 1: 415-424, 1990.
7. Keiss TD, Slebos RJ, Nelson WG, Kastan MB, Plunkett BS, Han SM, Lorincz AR, Hedrick L and Cho KR: Human papillomavirus 16E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci USA 90: 3988-3992, 1993.
8. Demers GW, Foster SA, Halbert CL and Galloway DA: Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc Natl Acad Sci USA 91: 4382-4386, 1994.
9. Hickman ES, Picksley SM and Vousden KH: Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation. Oncogene 9: 2177-2181, 1994.
10. Werness BA, Levine AJ and Howley PM: Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248: 76-79, 1990.
11. Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM: The E6 oncoproteins encoded by human papillomavirus types 16 and 18 promote the degradation of p53. Cell 63: 1129-1136, 1990.
12. Boyer SN, Wazer DE and Band V: E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 56: 4620-4624, 1996.
13. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR and Schiller JT: HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 8: 3905-3910, 1989.
14. Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T and Ishibashi M: Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophilia discs large tumor suppressor protein. Proc Natl Acad Sci USA 94: 11612-11616, 1997.
15. Havre PA, Yuan J, Hedrick L, Cho KR and Glazer PM: p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Res 55: 4420-4424, 1995.
16. Klingelhutz AJ, Foster SA and McDougall JK: Telomerase activation by the E6 gene protein product of human papilloma-virus type 16. Nature 380: 79-82, 1996.
17. Song S, Gulliver GA and Lambert PF: Human papillomavirus type 16 E6 and E7 genes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways. Proc Natl Acad Sci USA 95: 2290-2295, 1998.
18. Foster SA, Demers GW, Etscheid BG and Galloway DA: The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest. J Virol 68: 5698-5705, 1994.
19. Guo W, Baluda MA and Park NH: Ethanol upregulates the expression of p21 WAF1/CIP1 and prolongs G1 transition via a p53-independent pathway in human epithelial cells. Oncogene 15: 1143-1149, 1997.
20. Kendal WS and Frost P: Pitfalls and practice of Luria-Delbruck fluctuation analysis. A review. Cancer Res 48: 1060-1065, 1988.
21. Keen N, Elston R and Crawford L: Interaction of the E6 protein of human papillomavirus with cellular proteins. Oncogene 9: 1493-1499, 1994.
22. Kinoshita T, Shirasawa H, Shino Y, Moriya H, Desbarats L, Eilers M and Simizu B: Transactivation of prothymosin α and c-myc promoters by human papillomavirus type 16 E6 protein. Virology 232: 53-61, 1997.
23. Dey A, Atcha IA and Bagchi S: HPV16E6 oncoprotein stimulates the transforming growth factor-β1 promoter in fibroblasts through a specific GC-rich sequence. Virology 228: 190-199, 1997.
24. Akutsu N, Shirasawa H, Asano T, Isono K and Simizu B: p53-dependent and -independent transactivation by the E6 protein of human papillomavirus type 16. J Gen Virol 77: 459-463, 1996.
25. Crook T, Tidy JA and Vousden KH: Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell 67: 547-556, 1991.
26. Lue RA, Marfatia SM, Branton D and Chishti AH: Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci USA 91: 9818-9822, 1994.
27. Woods DF and Bryant PJ: The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66: 451-464, 1991.
28. Lee SS, Weiss RS and Javier RT: Binding or human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci USA 94: 6670-6675, 1997.
29. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg G-H, Kawahara T, Kobayashi S, Okada M, Toyoshima K and Akiyama T: Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272: 1020-1023, 1992.
30. He T-C, Sparks AB, Rago C, Hermeking H, Zawel L, Da Costa LT, Mortin PJ, Vogelstein B and Kinzler KW: Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512, 1998.
31. Steenbergen RD, Walboomers JM, Meijer CJ, van der Raaij-Helmer EM, Parker JN, Chow LT, Broker TR and Snijders PJ: Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene 13: 1249-1257, 1996.